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LaniceMine

Product Name
LaniceMine
CAS No.
153322-05-5
Chemical Name
LaniceMine
Synonyms
LaniceMine;(1S)-1-phenyl-2-pyridin-2-ylethanamine;2-PyridineethanaMine, a-phenyl-, (aS)-;2-Pyridineethanamine, α-phenyl-, (αS)-;(S)-1-phenyl-2-(pyridin-2-yl)ethanamine;(1S)-1-PHENYL-2-(PYRIDIN-2-YL)ETHAN-1-AMINE
CBNumber
CB12611425
Molecular Formula
C13H14N2
Formula Weight
198.27
MOL File
153322-05-5.mol
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LaniceMine Property

Boiling point:
307.7±27.0 °C(Predicted)
Density 
1.097±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≤20mg/ml in ethanol;30mg/ml in DMSO;5mg/ml in dimethyl formamide
form 
neat oil
pka
8.29±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
9002129
Product name
Lanicemine
Purity
≥95%
Packaging
5mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
9002129
Product name
Lanicemine
Purity
≥95%
Packaging
10mg
Price
$95
Updated
2024/03/01
Cayman Chemical
Product number
9002129
Product name
Lanicemine
Purity
≥95%
Packaging
25mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
9002129
Product name
Lanicemine
Purity
≥95%
Packaging
50mg
Price
$300
Updated
2024/03/01
TRC
Product number
L173950
Product name
Lanicemine
Packaging
5mg
Price
$40
Updated
2021/12/16
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LaniceMine Chemical Properties,Usage,Production

Description

Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 μM) that binds to sites within the channel pore with a Ki value of 0.56-2.1 μM. Compared to ketamine , lanicemine exhibits a lower propensity to be trapped within the NMDA channel (86% versus 54% trapping) following removal and reapplication of glutamate. It has been examined for its potential to produce antidepressant effects without adverse psychotomimetic activity.

Uses

Lanicemine is a non-selective voltage-dependant NMDA channel blocker. It is a potential anti-depressant which does not cause psychotomimetic activity. Potential anti-hypertensive agent.

in vitro

previous study with lanicemine and ketamine found that both compounds could bind with low-to-moderate affinity to sites within the nmda channel pore, exhibit strong voltage dependence, and have similar lack of nr2a vs nr2b subunit selectivity [1].

in vivo

in animal study, cortical eeg recordings were obtained from rats trained to perform an auditory detection task for food reward. results showed that both lanicemine and ketamine produced pronounced dose-dependent elevations in spontaneous gamma-band eeg, but only gamma changes for ketamine were tightly coupled to increases in locomotor activity, indicating that lanicemine not only engaged brain circuits involved in the generation of gamma-eeg, but also influenced these networks independent of the broader systemslevel disruptions typical of ketamine [1].

IC 50

4-7 μm

References

[1] g. sanacora, m. a. smith, s. pathak, et al. lanicemine: a low-trapping nmda channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. molecular psychiatry 19(9), 978-985 (2014).

LaniceMine Preparation Products And Raw materials

Raw materials

Preparation Products

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LaniceMine Suppliers

China 28 United States 5 Global 33
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
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View Lastest Price from LaniceMine manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Lanicemine 153322-05-5
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-09-05

153322-05-5, LaniceMineRelated Search:


  • LaniceMine
  • 2-PyridineethanaMine, a-phenyl-, (aS)-
  • (1S)-1-phenyl-2-pyridin-2-ylethanamine
  • (S)-1-phenyl-2-(pyridin-2-yl)ethanamine
  • 2-Pyridineethanamine, α-phenyl-, (αS)-
  • (1S)-1-PHENYL-2-(PYRIDIN-2-YL)ETHAN-1-AMINE
  • 153322-05-5