ChemicalBook > CAS DataBase List > CGP77675

CGP77675

Product Name
CGP77675
CAS No.
234772-64-6
Chemical Name
CGP77675
Synonyms
CGP77675;CGP 77675; CGP-77675;CGP77675 >=98% (HPLC);1-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-ol;1-(2-{4-[4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl}ethyl)piperidin-4-ol;4-Piperidinol, 1-[2-[4-[4-aMino-5-(3-Methoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-7-yl]phenyl]ethyl]-
CBNumber
CB12614668
Molecular Formula
C26H29N5O2
Formula Weight
443.54
MOL File
234772-64-6.mol
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CGP77675 Property

storage temp. 
2-8°C
solubility 
DMSO: >10mg/mL
form 
powder
color 
white to beige
InChIKey
WUPXZZWTHIZICK-UHFFFAOYSA-N
SMILES
COc1cccc(c1)-c2cn(-c3ccc(CCN4CCC(O)CC4)cc3)c5ncnc(N)c25
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Safety

WGK Germany 
3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0314
Product name
CGP77675
Purity
≥98% (HPLC)
Packaging
5mg
Price
$174
Updated
2026/03/19
Sigma-Aldrich
Product number
SML0314
Product name
CGP77675
Purity
≥98% (HPLC)
Packaging
25mg
Price
$696
Updated
2026/03/19
Cayman Chemical
Product number
21089
Product name
CGP 77675
Purity
≥98%
Packaging
1mg
Price
$30
Updated
2021/12/16
Cayman Chemical
Product number
21089
Product name
CGP 77675
Purity
≥98%
Packaging
5mg
Price
$113
Updated
2021/12/16
Cayman Chemical
Product number
21089
Product name
CGP 77675
Purity
≥98%
Packaging
10mg
Price
$195
Updated
2021/12/16
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CGP77675 Chemical Properties,Usage,Production

Uses

CGP77675 has been used in the generation of mouse expanded potential stem cells.

General Description

CGP77675 belongs to the pyrrolopyrimidine class of inhibitors.

Biochem/physiol Actions

CGP77675 is a potent Src kinase inhibitor. CGP77675 is selective toward other protein kinases including Cdc2 (>500-fold), epidermal growth factor (EGF) receptor (7.5-fold), vascular endothelial growth factor receptor (>50-fold), and for v-Abl (15-fold) and focal adhesion kinase (Fak) (>25-fold).

in vivo

CGP77675 (1, 5, and 25 mg/kg; injected s.c.; twice a day) inhibits IL-1β-induced hypercalcemia in Mice[1].
CGP77675 (10 and 50 mg/kg; administered orally; twice a day for 6 weeks) partially prevents bone loss and rescues bone microarchitectural features in young ovx rats[1].

Animal Model:Male mice (Tif:MAGf; Novartis Animal Farm) of 25-30 g body[1]
Dosage:1, 5, and 25 mg/kg
Administration:Injected s.c.; twice a day
Result:Prevented IL-1β-induced hypercalcemia in mice without affecting serum amyloid protein levels.
Animal Model:Eight-week-old (175-209 g) female rats of the Sprague-Dawley-derived strain Tif:RAlf[1]
Dosage:10 and 50 mg/kg
Administration:Administered orally; twice a day for 6 weeks
Result:Partly prevented bone loss.

CGP77675 Preparation Products And Raw materials

Raw materials

Preparation Products

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CGP77675 Suppliers

China 23 India 1 United States 9 Global 33
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
Tel
025-58196018 800028039
Fax
025-83453306
Email
sales@fartop.net
Country
China
ProdList
2229
Advantage
55
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Chengdu Chuangkecheng Biological Technology Co., Ltd.
Tel
028-028-0000000 13008177686
Fax
15928581901
Email
sales@ckcbiotech.com
Country
China
ProdList
899
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44896
Advantage
58

234772-64-6, CGP77675Related Search:


  • CGP77675
  • 4-Piperidinol, 1-[2-[4-[4-aMino-5-(3-Methoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-7-yl]phenyl]ethyl]-
  • 1-(2-{4-[4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl}ethyl)piperidin-4-ol
  • 1-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-ol
  • CGP 77675; CGP-77675
  • CGP77675 >=98% (HPLC)
  • 234772-64-6