DiMethyl 1H-pyrrole-2,4-dicarboxylate

Product Name: DiMethyl 1H-pyrrole-2,4-dicarboxylate
CAS No.: 2818-07-7
Chemical Name: DiMethyl 1H-pyrrole-2,4-dicarboxylate
Synonyms: DiMethyl 1H-pyrrole-2,4-dicarboxylate;pyrrole-2,4-dicarboxylic acid diMethyl ester;1H-Pyrrole-2,4-dicarboxylic acid, 2,4-dimethyl ester
CBNumber: CB12616970
Molecular Formula: C8H9NO4
Formula Weight: 183.16
MOL File: 2818-07-7.mol

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DiMethyl 1H-pyrrole-2,4-dicarboxylate Property

Melting point:: 125-126 °C(Solv: methanol (67-56-1))
Boiling point:: 355.0±22.0 °C(Predicted)
Density: 1.276±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 13.58±0.50(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FD143649
Product name: Dimethyl 1H-pyrrole-2,4-dicarboxylate
Packaging: 250mg
Price: $82.5
Updated: 2021/12/16

AK Scientific

Product number: W5105
Product name: Dimethyl1H-pyrrole-2,4-dicarboxylate
Packaging: 250mg
Price: $178
Updated: 2021/12/16

Apolloscientific

Product number: OR926541
Product name: Dimethyl1H-pyrrole-2,4-dicarboxylate
Purity: 95%
Packaging: 250mg
Price: $185
Updated: 2021/12/16

Oakwood

Product number: 091875
Product name: Dimethyl1H-pyrrole-2,4-dicarboxylate
Purity: 95+%
Packaging: 1g
Price: $195
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD143649
Product name: Dimethyl 1H-pyrrole-2,4-dicarboxylate
Packaging: 1g
Price: $252
Updated: 2021/12/16

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DiMethyl 1H-pyrrole-2,4-dicarboxylate Chemical Properties,Usage,Production

Synthesis

39687-95-1

922-67-8

2818-07-7

Step A: To a solution of dioxane (200 mL) containing cuprous oxide (832 mg, 5.9 mmol) and 1,10-phenanthroline (2.14 g, 11.89 mmol) was added sequentially methyl propargylate (10 g, 118.9 mmol) and methyl isocyanoacetate (8.95 g, 98.6 mmol) under nitrogen protection. The reaction mixture was heated with stirring at 100 °C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through a diatomaceous earth pad to remove the solid catalyst. The filtrate was concentrated under reduced pressure to remove the solvent and the resulting crude product was purified by silica gel column chromatography using a solvent mixture of ethyl acetate-hexane as eluent. The target fraction was collected and concentrated to give dimethyl 1H-pyrrole-2,4-dicarboxylate (8.6 g, 48% yield) as a white solid. The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 300 MHz, DMSO-d6): δ 12.55 (s, 1H), 7.60 (s, 1H), 7.10 (s, 1H), 3.92 (s, 3H), 3.90 (s, 3H); liquid chromatography-mass spectrometry (LC-MS, ESI) showed the molecular ion peak m/z 184 ([M+H] +).

References

[1] Patent: WO2010/2472, 2010, A1. Location in patent: Page/Page column 118-119

DiMethyl 1H-pyrrole-2,4-dicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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2818-07-7, DiMethyl 1H-pyrrole-2,4-dicarboxylateRelated Search:

DiMethyl 1H-pyrrole-2,4-dicarboxylate

pyrrole-2,4-dicarboxylic acid diMethyl ester

1H-Pyrrole-2,4-dicarboxylic acid, 2,4-dimethyl ester

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