2-Methyl-7-(trifluoroMethyl)quinoline
- Product Name
- 2-Methyl-7-(trifluoroMethyl)quinoline
- CAS No.
- 324-32-3
- Chemical Name
- 2-Methyl-7-(trifluoroMethyl)quinoline
- Synonyms
- N-(4-IODO-2-PYRIDINYL)ACETAMIDE;2-Methyl-7-(trifluoroMethyl)quinoline;Quinoline, 2-methyl-7-(trifluoromethyl)-
- CBNumber
- CB12620698
- Molecular Formula
- C11H8F3N
- Formula Weight
- 211.18
- MOL File
- 324-32-3.mol
2-Methyl-7-(trifluoroMethyl)quinoline Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933491090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M343028
- Product name
- 2-Methyl-7-(trifluoromethyl)quinoline
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- PC53178
- Product name
- 2-Methyl-7-(trifluoromethyl)quinoline
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $143
- Updated
- 2021/12/16
- Product number
- 3620AB
- Product name
- 2-Methyl-7-(trifluoromethyl)quinoline
- Packaging
- 100mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 3H32-3-2V
- Product name
- 2-Methyl-7-(trifluoromethyl)quinoline
- Purity
- 97%
- Packaging
- 250mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- 3620AB
- Product name
- 2-Methyl-7-(trifluoromethyl)quinoline
- Packaging
- 250mg
- Price
- $209
- Updated
- 2021/12/16
2-Methyl-7-(trifluoroMethyl)quinoline Chemical Properties,Usage,Production
Synthesis
123-73-9
98-16-8
324-32-3
General procedure for the synthesis of 2-methyl-7-(trifluoromethyl)quinoline from trans-2-butenal and m-aminobenzotrifluoride: To an aqueous 6N HCl solution (50 mL) of 3-(trifluoromethyl)aniline (12.43 mL, 99.92 mmol) was slowly added (E)-but-2-enal (18.77 mL, 229.8 mmol) dropwise under reflux conditions. The reaction mixture was stirred at reflux for 3 hours. After completion of the reaction, it was cooled to room temperature and diluted by adding ethyl acetate (200 mL). The aqueous layer was separated and the pH of the aqueous layer was adjusted to about 9 with ammonium hydroxide, followed by extraction with dichloromethane (2 x 200 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel fast column chromatography (eluent ratio 5:1 hexane/ethyl acetate) to afford the target product 2-methyl-7-(trifluoromethyl)quinoline (6.1 g, 28.9% yield) as a solid.
References
[1] Patent: WO2012/154274, 2012, A1. Location in patent: Page/Page column 87-88
2-Methyl-7-(trifluoroMethyl)quinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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