ChemicalBook > CAS DataBase List > R1487

R1487

Product Name: R1487
CAS No.: 449808-64-4
Chemical Name: R1487
Synonyms: R1487;CS-667;RI-487;CS-2169;SY-R1487;R1487 HCL;R-1487;R 1487;R1487 (Hydrochloride);R1487 (SY-R1487);R-1487 HYDROCHLORIDE;R 1487 HYDROCHLORIDE
CBNumber: CB12621145
Molecular Formula: C19H19ClF2N4O3
Formula Weight: 424.8289664
MOL File: 449808-64-4.mol

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R1487 Property

storage temp.: Store at -20°C
solubility: DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form: A crystalline solid
color: Light yellow to yellow

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5860
Product name: R1487(Hydrochloride)
Purity: 98.94%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-5860
Product name: R1487(Hydrochloride)
Purity: 98.94%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-5860
Product name: R1487(Hydrochloride)
Purity: 98.94%
Packaging: 25mg
Price: $348
Updated: 2021/12/16

AK Scientific

Product number: SYN1101
Product name: R1487HCl
Packaging: 25mg
Price: $484
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000782
Product name: R-1487
Purity: 95.00%
Packaging: 5MG
Price: $505.78
Updated: 2021/12/16

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R1487 Chemical Properties,Usage,Production

Uses

R1487 Hydrochloride is a highly potent and selective p38α inhibitor, with Kd values of 0.2 nM and 29 nM for p38α and p38β, respectively[1].

in vivo

R1487 (Compounds 2a, orally) demonstrates significant dose-dependent inhibition of serum TNFα and IL-1β^[1].
Oral bioavailability of 10 mg/kg R1487 (Compounds 2a) in monkey, rat, and dog was 51.6%, 29.3%, 10.3%, respectively^[1].

IC 50

p38α: 0.2 nM (Kd); p38β: 29 nM (Kd)

References

[1] Goldstein DM et al. Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54(7):2255-65. DOI:10.1021/jm101423y

R1487 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from R1487 manufacturers

Career Henan Chemical Co

Product: R1487 Hydrochloride 449808-64-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

449808-64-4, R1487Related Search:

R1487

SY-R1487

Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-difluorophenoxy)-8-Methyl-2-[(tetrahydro-2H-pyran-4-yl)aMino]-, (Hydrochloride) (1:1)

6-(2,4-Difluorophenoxy)-8-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride

R1487 HCL

R1487 (Hydrochloride)

R-1487 HYDROCHLORIDE;R 1487 HYDROCHLORIDE

R1487 (SY-R1487)

CS-667

R-1487;R 1487

CS-2169

RI-487

6-(2,4-difluorophenoxy)-8-methyl-2-[(oxan-4-yl)amino]-7H,8H-pyrido[2,3-d]pyrimidin-7-one hydrochloride

449808-64-4

C19H18F2N4O3HCl

C19H19ClF2N4O3