ChemicalBook > CAS DataBase List > 2,5-Cyclohexadiene-1,4-dione, 2-Methyl-5-(1-Methylethyl)-, 1-oxiMe

2,5-Cyclohexadiene-1,4-dione, 2-Methyl-5-(1-Methylethyl)-, 1-oxiMe

Product Name
2,5-Cyclohexadiene-1,4-dione, 2-Methyl-5-(1-Methylethyl)-, 1-oxiMe
CAS No.
17302-61-3
Chemical Name
2,5-Cyclohexadiene-1,4-dione, 2-Methyl-5-(1-Methylethyl)-, 1-oxiMe
Synonyms
1-oxime;PoloxiMe;5-Cyclohexadiene-1;2-methyl-5-(1-methylethyl)-;p-Mentha-3,6-diene-2,5-dione 2-oxime;4-(Hydroxyimino)-2-isopropyl-5-methylcyclohexa-2,5-dien-1-one;2,5-Cyclohexadiene-1,4-dione, 2-Methyl-5-(1-Methylethyl)-, 1-oxiMe
CBNumber
CB12623846
Molecular Formula
C10H13NO2
Formula Weight
179.22
MOL File
17302-61-3.mol
More
Less

2,5-Cyclohexadiene-1,4-dione, 2-Methyl-5-(1-Methylethyl)-, 1-oxiMe Property

Melting point:
162℃ (Decomposition)
Boiling point:
296.8±33.0 °C(Predicted)
Density 
1.10±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
6.43±0.58(Predicted)
form 
Powder
color 
Light yellow to yellow
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
A102086
Product name
Poloxime
Packaging
100mg
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-1334
Product name
Poloxime
Packaging
5mg
Price
$78
Updated
2021/12/16
ApexBio Technology
Product number
B3609
Product name
Poloxime
Packaging
5mg
Price
$103
Updated
2021/12/16
ChemScene
Product number
CS-1334
Product name
Poloxime
Packaging
10mg
Price
$114
Updated
2021/12/16
ApexBio Technology
Product number
B3609
Product name
Poloxime
Packaging
10mg
Price
$166
Updated
2021/12/16
More
Less

2,5-Cyclohexadiene-1,4-dione, 2-Methyl-5-(1-Methylethyl)-, 1-oxiMe Chemical Properties,Usage,Production

Uses

Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.

Biological Activity

Poloxime is a hydrolysis product of poloxin, a non-competitive ATP inhibitor of Plk1, which can properly inhibit the activity of Plk1.

in vitro

Poloxime (100 μM) inhibits phosphopeptide binding to polo-box domain (PBD) of polo-like kinase 1 (Plk1).

target

PLK1

IC 50

PLK1

References

[1] Liu M, et al. Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors. Bioorg Med Chem Lett. 2015 Feb 1;25(3):431-4. DOI:10.1016/j.bmcl.2014.12.060
[2] Yin Z, et al. Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic. ACS Chem Biol. 2013 Feb 15;8(2):303-8. DOI:10.1021/cb3004379

2,5-Cyclohexadiene-1,4-dione, 2-Methyl-5-(1-Methylethyl)-, 1-oxiMe Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2,5-Cyclohexadiene-1,4-dione, 2-Methyl-5-(1-Methylethyl)-, 1-oxiMe Suppliers

China 37 United States 7 Global 44
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
Chengdu Huachun Technology Co., Ltd
Tel
400-1166-196 15982826727
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 18438616290
Email
lanwu@univ-bio.com
Country
China
ProdList
24731
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
Advantage
58
Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58
Guangzhou Tuoshan Biotechnology Co., Ltd.
Tel
19928332050
Country
CHINA
ProdList
161
Advantage
58
Shanghai Shitang Industrial Co., Ltd.
Tel
17301778918
Country
CHINA
ProdList
105
Advantage
58
Tianjin Baibei Biotechnology Co., Ltd.
Tel
15302170631
Country
CHINA
ProdList
166
Advantage
58
Chongqing Boer Biotechnology Co., Ltd.
Tel
13251428727， 13368356747
Country
CHINA
ProdList
157
Advantage
58
Guangzhou Kati Biotechnology Co., Ltd.
Tel
13128698830
Country
CHINA
ProdList
199
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Shanghai Sige Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
2801747566@qq.com
Country
CHINA
ProdList
4902
Advantage
58
Guangzhou Weijia Technology Co., Ltd.
Tel
--
Fax
--
Email
WHIGA22@126.COM
Country
CHINA
ProdList
6757
Advantage
58
Shanghai Zhenyu Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
2836767067@qq.com
Country
CHINA
ProdList
6970
Advantage
58
Shanghai Wowu Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shhebio@126.com
Country
CHINA
ProdList
6137
Advantage
58
Shanghai Qiming Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6502
Advantage
58
Beijing Baiao Laibo Technology Co., Ltd.
Tel
--
Fax
--
Email
570202610@qq.com
Country
CHINA
ProdList
6851
Advantage
58
Shanghai Hao Test Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
prbiological@sohu.com
Country
CHINA
ProdList
6976
Advantage
58
Shanghai Chaoyan Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
471161314@qq.com
Country
CHINA
ProdList
6210
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
Advantage
58
Shanghai Machine Pure Industrial Co., Ltd.
Tel
--
Fax
--
Email
3245176082@qq.com
Country
CHINA
ProdList
6800
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6906
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
market@xlswkj.com
Country
CHINA
ProdList
6793
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Shanghai Yuda Industrial Co., Ltd.
Tel
--
Fax
--
Email
lucy@runwelltac.com
Country
CHINA
ProdList
6448
Advantage
58

17302-61-3, 2,5-Cyclohexadiene-1,4-dione, 2-Methyl-5-(1-Methylethyl)-, 1-oxiMeRelated Search:


  • 2,5-Cyclohexadiene-1,4-dione, 2-Methyl-5-(1-Methylethyl)-, 1-oxiMe
  • PoloxiMe
  • p-Mentha-3,6-diene-2,5-dione 2-oxime
  • 1-oxime
  • 2-methyl-5-(1-methylethyl)-
  • 5-Cyclohexadiene-1
  • 4-(Hydroxyimino)-2-isopropyl-5-methylcyclohexa-2,5-dien-1-one
  • 17302-61-3