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MGlu2 agonist

Product Name: MGlu2 agonist
CAS No.: 1311385-32-6
Chemical Name: MGlu2 agonist
Synonyms: MGlu2 agonist;LY-2979165;LY 2979165;LY2979165 Ammonium salt;Ammonium (1R,2S,4R,5R,6R)-4-((1H-1,2,4-triazol-5-yl)thio)-2-((S)-2-aminopropanamido)-2-carboxybicyclo[3.1.0]hexane-6-carboxylate hydrate;(1R,2S,4R,5R,6R)-2-[[(2S)-2-Amino-1-oxopropyl]amino]-4-(1H-1,2,4-triazol-5-ylthio)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid ammonium salt hydrate (1:1:1);Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-[[(2S)-2-aMino-1-oxopropyl]aMino]-4-(1H-1,2,4-triazol-5-ylthio)-, aMMoniuM salt, hydrate (1:1:1), (1R,2S,4R,5R,6R)-;(1R,2S,4R,5R,6R)-2-[[(2S)-2-Amino-1-oxopropyl]amino]-4-(1H-1,2,4-triazol-5-ylthio)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid ammonium salt hydrate (1:1:1) LY2979165
CBNumber: CB12624232
Molecular Formula: C13H22N6O6S
Formula Weight: 390.41538
MOL File: 1311385-32-6.mol

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MGlu2 agonist Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3601
Product name: mGlu2agonist
Packaging: 1mg
Price: $173
Updated: 2021/12/16

AK Scientific

Product number: 2838AH
Product name: (1R,2S,4R,5R,6R)-4-((4H-1,2,4-Triazol-3-yl)thio)-2-((S)-2-aminopropanamido)bicyclo[3.1.0]hexane-2,6-dicarboxylicacid,ammoniasalthydrate
Packaging: 1mg
Price: $186
Updated: 2021/12/16

ChemScene

Product number: CS-0457
Product name: LY2979165
Purity: ≥98.0%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

AK Scientific

Product number: 2838AH
Product name: (1R,2S,4R,5R,6R)-4-((4H-1,2,4-Triazol-3-yl)thio)-2-((S)-2-aminopropanamido)bicyclo[3.1.0]hexane-2,6-dicarboxylicacid,ammoniasalthydrate
Packaging: 5mg
Price: $428
Updated: 2021/12/16

ApexBio Technology

Product number: A3601
Product name: mGlu2agonist
Packaging: 5mg
Price: $454
Updated: 2021/12/16

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MGlu2 agonist Chemical Properties,Usage,Production

Uses

LY2979165 is the alanine proagent of 2812223, a selective and potent orthosteric mGlu2 receptor agonist[1].

in vivo

LY2979165 attenuated the ketamine-evoked BOLD phMRI signal in vivo^[2].

IC 50

mGlu2 Receptor

References

[1] Juliet McColm , et al. Evaluation of Single and Multiple Doses of a Novel mGlu2 Agonist, a Potential Antipsychotic Therapy, in Healthy Subjects. Br J Clin Pharmacol. 2017 Aug;83(8):1654-1667. DOI:10.1111/bcp.13252
[2] Mitul A Mehta, et al. Group II metabotropic glutamate receptor agonist prodrugs LY2979165 and LY2140023 attenuate the functional imaging response to ketamine in healthy subjects. Psychopharmacology (Berl). 2018 Jul;235(7):1875-1886. DOI:10.1007/s00213-018-4877-9

MGlu2 agonist Preparation Products And Raw materials

Raw materials

Preparation Products

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1311385-32-6, MGlu2 agonistRelated Search:

MGlu2 agonist

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-[[(2S)-2-aMino-1-oxopropyl]aMino]-4-(1H-1,2,4-triazol-5-ylthio)-, aMMoniuM salt, hydrate (1:1:1), (1R,2S,4R,5R,6R)-

(1R,2S,4R,5R,6R)-2-[[(2S)-2-Amino-1-oxopropyl]amino]-4-(1H-1,2,4-triazol-5-ylthio)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid ammonium salt hydrate (1:1:1)

LY-2979165;LY 2979165

(1R,2S,4R,5R,6R)-2-[[(2S)-2-Amino-1-oxopropyl]amino]-4-(1H-1,2,4-triazol-5-ylthio)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid ammonium salt hydrate (1:1:1) LY2979165

LY2979165 Ammonium salt

Ammonium (1R,2S,4R,5R,6R)-4-((1H-1,2,4-triazol-5-yl)thio)-2-((S)-2-aminopropanamido)-2-carboxybicyclo[3.1.0]hexane-6-carboxylate hydrate

1311385-32-6

C13H17N5O5SNH3H2O

C13H22N6O6S