ChemicalBook > CAS DataBase List > ROCK-II inhibitor
ROCK-II inhibitor
- Product Name
- ROCK-II inhibitor
- CAS No.
- 1273579-40-0
- Chemical Name
- ROCK-II inhibitor
- Synonyms
- chroMan 1;ROCK-II inhibitor;(S)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-6-methoxychroman-3-carboxamide;(3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide;2H-1-Benzopyran-3-carboxamide, N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-, (3S)-;glaucoma,Chroman1,injury,cord,inhibit,ROCK,Rho-associated protein kinase,rho kinase,Chroman-1,Rho-kinase,ROK,Chroman 1,spinal,Rho-associated kinase,Inhibitor
- CBNumber
- CB12624292
- Molecular Formula
- C24H28N4O4
- Formula Weight
- 436.5
- MOL File
- 1273579-40-0.mol
More
Less
ROCK-II inhibitor Property
- Boiling point:
- 675.9±55.0 °C(Predicted)
- Density
- 1.256±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 13.08±0.70(Predicted)
- color
- White to pink
More
Less
N-Bromosuccinimide Price
Tocris
- Product number
- 7163
- Product name
- Chroman1
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $316
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0775
- Product name
- Chroman1
- Purity
- 99.90%
- Packaging
- 5mg
- Price
- $343
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A3310
- Product name
- chroman1
- Packaging
- 5mg
- Price
- $419
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0775
- Product name
- Chroman1
- Purity
- 99.90%
- Packaging
- 10mg
- Price
- $678
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A3310
- Product name
- chroman1
- Packaging
- 10mg
- Price
- $827
- Updated
- 2021/12/16
More
Less
ROCK-II inhibitor Chemical Properties,Usage,Production
Biological Activity
chroman 1 is a highly potent rock-ii inhibitor. rock is a member of the agc kinase family of serine/threonine kinases that is comprised of two highly homologous isoforms, which are rock-i and rock-ii.. as one of the downstream effectors of rhoa, rock regulates stress fiber formation and actin cytoskeletal organization via phosphorylation of myosin light chain. currently, there is plenty of interest in the inhibition of rho kinase (rock) to treat various diseases.
in vitro
chroman 1 was found to be a sub-nanomolar rock-ii inhibitor with excellent to moderate selectivity over related kinases studied as a preliminary assessment, such as akt1, protein kinase a (pka), and the highly homologous cdc42-binding kinase. in addition, chroman 1 also showed good in-vitro activity in the functional cell-based myosin light chain bis-phosphorylation assay [1].
in vivo
pharmacokinetic evaluation in rats showed that chroman 1 had moderately improved oral bioavailability (27–35%) relative to its lead compounds, which were benzodioxane and chroman. in addition, chroman 1 also displayed an unique intriguing pharmacokinetic profile, which was with high systemic exposure through oral delivery [1].
IC 50
<1 nm for rock-ii
References
[1] chen yt,bannister td,weiser a,griffin e,lin l,ruiz c,cameron md,schürer s,duckett d,schrter t,lograsso p,feng y. chroman-3-amides as potent rho kinase inhibitors. bioorg med chem lett.2008 dec 15;18(24):6406-9.
ROCK-II inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
ROCK-II inhibitor Suppliers
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4674
- Advantage
- 55
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7887
- Advantage
- 56
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
- ProdList
- 2384
- Advantage
- 58
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3866
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30237
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 021-61998551 13122364865
- sale1@shzysw.net
- Country
- China
- ProdList
- 9772
- Advantage
- 58
- Tel
- 020-82000279 18988968278
- Fax
- QQ：3283937693
- sales@ubiochem.com
- Country
- China
- ProdList
- 4297
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- wulan@absin.cn
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 16621358918
- Fax
- QQ:402135374
- botuopharma888@163.com
- Country
- China
- ProdList
- 9208
- Advantage
- 58
- Tel
- 15342225168
- yutianchun2007@126.com
- Country
- China
- ProdList
- 10003
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29774
- Advantage
- 58
- Tel
- +86-027-59232304 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9998
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24644
- Advantage
- 58
- Tel
- 18171815831
- 1341138380@qq.com
- Country
- China
- ProdList
- 3670
- Advantage
- 58
- Tel
- 400-910-1997 17560619001
- 3243204476@qq.com
- Country
- China
- ProdList
- 9959
- Advantage
- 58
- Tel
- 0513-66337626 18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 4988
- Advantage
- 58
- Tel
- 14760821013 13564957716
- 1816280386@qq.com
- Country
- China
- ProdList
- 8045
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9266
- Advantage
- 58
- Tel
- 17316404525
- 209533805@qq.com
- Country
- China
- ProdList
- 9907
- Advantage
- 58
- Tel
- --
- Fax
- --
- market@xlswkj.com
- Country
- CHINA
- ProdList
- 6793
- Advantage
- 58
- Tel
- --
- Fax
- --
- 3245176082@qq.com
- Country
- CHINA
- ProdList
- 6134
- Advantage
- 58
- Tel
- --
- Fax
- --
- lucy@runwelltac.com
- Country
- CHINA
- ProdList
- 6105
- Advantage
- 58
- Tel
- --
- Fax
- --
- 471161314@qq.com
- Country
- CHINA
- ProdList
- 6210
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@wheybio.com
- Country
- CHINA
- ProdList
- 4398
- Advantage
- 58
- Tel
- --
- Fax
- --
- 15800446246@163.com
- Country
- CHINA
- ProdList
- 5416
- Advantage
- 58
- Tel
- --
- Fax
- --
- yihbio@163.com
- Country
- CHINA
- ProdList
- 5667
- Advantage
- 58
- Tel
- --
- Fax
- --
- WHIGA22@126.COM
- Country
- CHINA
- ProdList
- 6748
- Advantage
- 58
- Tel
- --
- Fax
- --
- SHYIJIEBIO@126.COM
- Country
- CHINA
- ProdList
- 3510
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@f-biology.com
- Country
- CHINA
- ProdList
- 6025
- Advantage
- 58
- Tel
- --
- Fax
- --
- john.st@163.com
- Country
- CHINA
- ProdList
- 1471
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6973
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1562893815@qq.com
- Country
- CHINA
- ProdList
- 6936
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6502
- Advantage
- 58
- Tel
- --
- Fax
- --
- shhebio@126.com
- Country
- CHINA
- ProdList
- 6137
- Advantage
- 58
- Tel
- --
- Fax
- --
- shxiyuanbio@163.com
- Country
- CHINA
- ProdList
- 6906
- Advantage
- 58
- Tel
- --
- Fax
- --
- 3245176082@qq.com
- Country
- CHINA
- ProdList
- 6800
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
1273579-40-0, ROCK-II inhibitorRelated Search:
N,N-DIMETHYLHYDROXYLAMINE HYDROCHLORIDE
N,N'-Dimethyl-1,3-propanediamine
N,N-Dimethylbenzylamine
N,N-Dimethylbenzamide
N,N-Dimethylpropionamide