1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2)
- Product Name
- 1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2)
- CAS No.
- 1191385-19-9
- Chemical Name
- 1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2)
- Synonyms
- MFCD18782676;5-isoquinolinediamine;B-Raf inhibitor 1 2HCl;Raf inhibitor 1 dihydrochloride;B-RAF Inhibitor 1 hydrochloride;B-Raf inhibitor 1 dihydrochloride;Raf inhibitor 1 dihydrochloride, 10 mM in DMSO;B-Raf inhibitor 1 (Compound 13) dihydrochloride;n1-(4-chlorophenyl)-6-methyl-n5-[3-(9h-purin-6-yl)-2-pyridinyl]-;N1-(4-CHLOROPHENYL)-6-METHYL-N5-[3-(9H-PURIN-6-YL)-2-PYRIDINYL]-1,5-ISOQUINOLINEDIAMINE 2HCL
- CBNumber
- CB12625204
- Molecular Formula
- C26H21Cl3N8
- Formula Weight
- 551.87
- MOL File
- 1191385-19-9.mol
1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2) Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 26792
- Product name
- B-RAF Inhibitor 1 (hydrochloride)
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 26792
- Product name
- B-RAF Inhibitor 1 (hydrochloride)
- Packaging
- 25mg
- Price
- $618
- Updated
- 2024/03/01
- Product number
- 26792
- Product name
- B-RAF Inhibitor 1 (hydrochloride)
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 26792
- Product name
- B-RAF Inhibitor 1 (hydrochloride)
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- BISN0297
- Product name
- B-Raf inhibitor 1 dihydrochloride
- Packaging
- 1mg
- Price
- $108
- Updated
- 2021/12/16
1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2) Chemical Properties,Usage,Production
Uses
B-Raf inhibitor 1 dihydrochloride is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively.
Biological Activity
b-raf inhibitor 1 is an inhibitor of b-raf kinase with ic50 values of 0.31μm and 0.72μm for cell proliferation, respectively in a375 and hct116 [1].b-raf is important in signal transduction and some mutant b-raf occurs in cancer cells. the most common mutation of these is v600e, which makes b-raf kinase constitutively active. b-raf inhibitor 1 belongs to the type iia inhibitors and binds to the dfg-out atp-binding site of b-raf. the selectivity of b-raf inhibitor 1 is less than of other type inhibitors. besides mutant b-raf, it can also inhibit wild type b-raf and other tyrosine kinase. in cells with wild type b-raf, b-raf inhibitor 1 can activate the raf-mek-erk signaling pathway via raf dimerization. the preclinical toxicity test shows b-raf inhibitor 1 can induce hyperplasia in a mouse model [1, 2].
in vitro
B-Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC 50 s of 0.31 and 0.72 μM, respectively. B-Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif.
target
A375 proliferation
IC 50
B-Raf: 1 nM (Ki); B-RafV600E: 1 nM (Ki); c-Raf: 0.3 nM (Ki)
References
[1] wang x, kim j. conformation-specific effects of raf kinase inhibitors. j med chem. 2012 sep 13;55(17):7332-41.
[2] smith al, demorin ff, paras na, huang q, petkus jk, doherty em, nixey t, kim jl, whittington da, epstein lf, lee mr, rose mj, babij c, fernando m, hess k, le q, beltran p, carnahan j. selective inhibitors of the mutant b-raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline. j med chem. 2009 oct 22;52(20):6189-92.
1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2) Preparation Products And Raw materials
Raw materials
Preparation Products
1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, (Hydrochloride) (1:2) Suppliers
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 12952
- Advantage
- 65
- Tel
- +21-18501659228 18501659228
- Fax
- sales@hope-chem.com
- info@hope-chem.com
- Country
- China
- ProdList
- 492
- Advantage
- 55
- Tel
- sales@witofly.com
- Country
- China
- ProdList
- 2864
- Advantage
- 52
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4817
- Advantage
- 55
- Tel
- 021-61350663 13052117465
- Fax
- 021-61350662
- sales@zehanbiopharma.com
- Country
- China
- ProdList
- 977
- Advantage
- 55
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- 13764913901
- Fax
- -
- info@angtibio.com
- Country
- China
- ProdList
- 4976
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 86249
- Advantage
- 60
- Tel
- 18930833303 18930833303
- Fax
- +86 (21) 2024-2659
- sales@changyanchem.cn
- Country
- China
- ProdList
- 5001
- Advantage
- 55
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 7999
- Advantage
- 62