ChemicalBook > CAS DataBase List > 3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl-
3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl-
- Product Name
- 3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl-
- CAS No.
- 875634-01-8
- Chemical Name
- 3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl-
- Synonyms
- PPY A;5-[3-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylpyridine-3-carboxamide;5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide;3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl-
- CBNumber
- CB12626827
- Molecular Formula
- C22H20N4O2
- Formula Weight
- 372.42
- MOL File
- 875634-01-8.mol
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3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl- Property
- Density
- 1.248±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- <37.24mg/ml in DMSO
- pka
- 12.93±0.40(Predicted)
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N-Bromosuccinimide Price
Tocris
- Product number
- 4730
- Product name
- PPYA
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $261
- Updated
- 2021/12/16
Tocris
- Product number
- 4730
- Product name
- PPYA
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $1056
- Updated
- 2021/12/16
Usbiological
- Product number
- 256316
- Product name
- PPY A
- Packaging
- 10mg
- Price
- $516
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A8607
- Product name
- PPYA
- Packaging
- 50mg
- Price
- $1568
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A8607
- Product name
- PPYA
- Packaging
- 10mg
- Price
- $385
- Updated
- 2021/12/16
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3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl- Chemical Properties,Usage,Production
Uses
PPY-A is a potent T315I mutant and wild-type Abl kinases inhibitor with IC50s of 9 and 20 nM, respectively. PPY-A inhibits Ba?F3 cells transformed with wild-type Abl and Abl T315I mutantl with IC50s of 390 and 180 nM, respectively. PPY-A can be used for the research of chronic myeloid leukemia (CML)[1].
storage
Store at -20°C
References
[1] Tianjun Zhou, et al. Crystal structure of the T315I mutant of AbI kinase. Chem Biol Drug Des. 2007 Sep;70(3):171-81. DOI:10.1111/j.1747-0285.2007.00556.x
3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl- Preparation Products And Raw materials
Raw materials
Preparation Products
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3-PyridinecarboxaMide, 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-diMethyl- Suppliers
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