ChemicalBook > CAS DataBase List > ABT-348

ABT-348

Product Name: ABT-348
CAS No.: 1227939-82-3
Chemical Name: ABT-348
Synonyms: ABT-348;A-968660;Vilaprisan;A 968660.0;Ilorasertib;Abbott 968660;ILORASERTIB (ABT-348);N-[4-[4-Amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl]phenyl]-N'-(3-fluorophenyl)urea;Urea, N-[4-[4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl]phenyl]-N'-(3-fluorophenyl)-;anti-tumor,H1299,Platelet-derived growth factor receptor,Inhibitor,ABT 348,antiproliferative activity,AML,VEGFR,Ilorasertib,histone H3 phosphorylation,ABT348,Vascular endothelial growth factor receptor,PDGFR,Aurora Kinase,inhibit,H460 cells,MDS
CBNumber: CB12627248
Molecular Formula: C25H21FN6O2S
Formula Weight: 488.54
MOL File: 1227939-82-3.mol

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ABT-348 Property

Boiling point:: 675.7±55.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Ethanol: soluble
form: A solid
pka: 13.56±0.70(Predicted)
color: Off-white to brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6804
Product name: Ilorasertib
Purity: ≥98.0%
Packaging: 50mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-6804
Product name: Ilorasertib
Purity: ≥98.0%
Packaging: 100mg
Price: $1100
Updated: 2021/12/16

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ABT-348 Chemical Properties,Usage,Production

Uses

Ilorasertib (ABT-348) is a potent, orally active and ATP-competitive aurora inhibitor with IC50s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib also is a potent VEGF, PDGF inhibitor. Ilorasertib has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)[1][2].

in vivo

Ilorasertib (6.25, 12.5, 25 mg/kg; p.o.) shows anti-tumor activity in MV-4-11 tumor-bearing SCID mice with TGI of 80%, 86%, 94% at 6.25, 12.5, 25 mg/kg, respectively^[1].
Ilorasertib (6.25, 12.5, 25 mg/kg; p.o.) shows anti-tumor activity in SKM-1 tumor-bearing SCID mice with TGI of 38%, 59%, 80% at 6.25, 12.5, 25 mg/kg, respectively^[1].
Ilorasertib (0, 3.75, 7.5, 15 mg/kg; i.p.) inhibits the histone H3 phosphorylation at 4-8 h in blood-borne tumor cells^[2].
Ilorasertib (0.2 mg/kg; i.v.) shows anti-VEGF activity in mouse^[2].
Ilorasertib (20 mg/kg; p.o.;once weekly for 3 weeks) shows anti-tumor activity in mouse^[2].

Animal Model:	Female SCID/beige mice^[2]
Dosage:	25 mg/kg
Administration:	Subcutaneous minipump; 24 h
Result:	Inhibited the histone H3 phosphorylation and the tumor drug concentration associated with 50% inhibition of histone H3 phosphorylation.

Animal Model:	22-26 g, female NOD/SCID mice (xenograft model of multiple myeloma (KMS11))^[2]
Dosage:	20 mg/kg
Administration:	P.o.; once weekly for 3 weeks
Result:	Inhibited the tumor growth in mouse.

IC 50

Aurora C: 1 nM (IC₅₀); Aurora B: 7 nM (IC₅₀); Aurora B (Y156H): 12 nM (IC₅₀); Aurora A: 120 nM (IC₅₀); PDGFRα: 11 nM (IC₅₀); PDGFRβ: 13 nM (IC₅₀); VEGFR1: 1 nM (IC₅₀); VEGFR2: 2 nM (IC₅₀); VEGFR3: 43 nM (IC₅₀); FLT3: 1 nM (IC₅₀); CSF-1R: 3 nM (IC₅₀); c-KIT: 20 nM (IC₅₀)

References

[1] Yi-Chun Wang, et al. Abstract 858: Potent in vivo activity of the aurora kinase inhibitor ABT-348 in human acute myeloid leukemia and myelodysplastic syndrome xenograft models. Cancer Res (2012) 72 (8_Supplement): 858.
[2] Glaser KB, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27. DOI:10.1124/jpet.112.197087

ABT-348 Preparation Products And Raw materials

Raw materials

Preparation Products

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1227939-82-3, ABT-348Related Search:

Vilaprisan

ABT-348

Ilorasertib

A 968660.0

Abbott 968660

N-[4-[4-Amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl]phenyl]-N'-(3-fluorophenyl)urea

ILORASERTIB (ABT-348)

Urea, N-[4-[4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl]phenyl]-N'-(3-fluorophenyl)-

anti-tumor,H1299,Platelet-derived growth factor receptor,Inhibitor,ABT 348,antiproliferative activity,AML,VEGFR,Ilorasertib,histone H3 phosphorylation,ABT348,Vascular endothelial growth factor receptor,PDGFR,Aurora Kinase,inhibit,H460 cells,MDS

A-968660

1227939-82-3

C25H21FN6O2S