BMS-687453
- Product Name
- BMS-687453
- CAS No.
- 1000998-59-3
- Chemical Name
- BMS-687453
- Synonyms
- CS-1533;BMS-687453;BMS-687453;BMS687453;BMS 687453;N-(3-{[2-(4-Chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyl)-N-(methoxycarbonyl)glycine;N-[[3-[[2-(4-Chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)glycine;BMS-687453,PPAR,Peroxisome proliferator-activated receptors,Inhibitor,BMS687453,inhibit,BMS 687453;Glycine, N-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)-;2-[[3-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl-methoxycarbonylamino]acetic acid
- CBNumber
- CB12627622
- Molecular Formula
- C22H21ClN2O6
- Formula Weight
- 444.86
- MOL File
- 1000998-59-3.mol
BMS-687453 Property
- Boiling point:
- 642.7±65.0 °C(Predicted)
- Density
- 1.342±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO
- form
- A crystalline solid
- pka
- 3.93±0.10(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 19404
- Product name
- BMS 687453
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 19404
- Product name
- BMS 687453
- Packaging
- 5mg
- Price
- $143
- Updated
- 2024/03/01
- Product number
- 19404
- Product name
- BMS 687453
- Packaging
- 10mg
- Price
- $254
- Updated
- 2024/03/01
- Product number
- 19404
- Product name
- BMS 687453
- Packaging
- 25mg
- Price
- $553
- Updated
- 2024/03/01
- Product number
- C3544
- Product name
- BMS687453
- Packaging
- 25mg
- Price
- $608
- Updated
- 2021/12/16
BMS-687453 Chemical Properties,Usage,Production
Biological Activity
bms 687453 is a pparα agonist.the peroxisome proliferator activated receptor (ppar) is a member of the intracellular nuclear hormone receptor superfamily of transcription factors, having pleiotropic effects on plasma lipoprotein levels, insulin sensitization, atherosclerosis, and inflammation.
in vitro
bms-687453 was identified as a potent and selective ppar alpha agonist, with approximately 410-fold selectivity versus human ppargamma in ppar-gal4 transactivation assays. in addition, similar potency and selectivity were also seen in the full length receptor co-transfection assays. [1].
in vivo
in previous study, bms-687453 had an excellent pharmacokinetic profile across all tested animal species. the oral absorption was rapid in mouse, rat, dog, and cynomulgus monkey. bms-687453 also exhibited low plasma clearance in the mouse, rat, and monkey and moderate plasma clearance in the dog. the half-life of bms-687453 ranged from 3 h in mouse to 12 h in cynomolgus monkeys. bms-687453 showed excellent absolute oral bioavailability ranging from 58% (dog) to 91% (rat) [1].
IC 50
10 nm for human pparα
References
[1] li j. discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl) amino)acetic acid (bms-687453). j med chem. 2010 apr 8;53(7):2854-64.
BMS-687453 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BMS-687453 manufacturers
- Product
- 2-[[3-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl-methoxycarbonylamino]acetic acid 1000998-59-3
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- Min98% HPLC
- Supply Ability
- g/kg /ton
- Release date
- 2019-12-20