BMS-687453

Product Name: BMS-687453
CAS No.: 1000998-59-3
Chemical Name: BMS-687453
Synonyms: CS-1533;BMS-687453;BMS-687453;BMS687453;BMS 687453;N-(3-{[2-(4-Chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyl)-N-(methoxycarbonyl)glycine;N-[[3-[[2-(4-Chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)glycine;BMS-687453,PPAR,Peroxisome proliferator-activated receptors,Inhibitor,BMS687453,inhibit,BMS 687453;Glycine, N-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)-;2-[[3-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl-methoxycarbonylamino]acetic acid
CBNumber: CB12627622
Molecular Formula: C22H21ClN2O6
Formula Weight: 444.86
MOL File: 1000998-59-3.mol

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BMS-687453 Property

Boiling point:: 642.7±65.0 °C(Predicted)
Density: 1.342±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO
form: A crystalline solid
pka: 3.93±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19404
Product name: BMS 687453
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 19404
Product name: BMS 687453
Packaging: 5mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 19404
Product name: BMS 687453
Packaging: 10mg
Price: $254
Updated: 2024/03/01

Cayman Chemical

Product number: 19404
Product name: BMS 687453
Packaging: 25mg
Price: $553
Updated: 2024/03/01

ApexBio Technology

Product number: C3544
Product name: BMS687453
Packaging: 25mg
Price: $608
Updated: 2021/12/16

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BMS-687453 Chemical Properties,Usage,Production

Biological Activity

bms 687453 is a pparα agonist.the peroxisome proliferator activated receptor (ppar) is a member of the intracellular nuclear hormone receptor superfamily of transcription factors, having pleiotropic effects on plasma lipoprotein levels, insulin sensitization, atherosclerosis, and inflammation.

in vitro

bms-687453 was identified as a potent and selective ppar alpha agonist, with approximately 410-fold selectivity versus human ppargamma in ppar-gal4 transactivation assays. in addition, similar potency and selectivity were also seen in the full length receptor co-transfection assays. [1].

in vivo

in previous study, bms-687453 had an excellent pharmacokinetic profile across all tested animal species. the oral absorption was rapid in mouse, rat, dog, and cynomulgus monkey. bms-687453 also exhibited low plasma clearance in the mouse, rat, and monkey and moderate plasma clearance in the dog. the half-life of bms-687453 ranged from 3 h in mouse to 12 h in cynomolgus monkeys. bms-687453 showed excellent absolute oral bioavailability ranging from 58% (dog) to 91% (rat) [1].

IC 50

10 nm for human pparα

References

[1] li j. discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl) amino)acetic acid (bms-687453). j med chem. 2010 apr 8;53(7):2854-64.

BMS-687453 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-687453 Suppliers

China 55 United States 10 Global 65

Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Aladdin Scientific

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TargetMol Chemicals Inc.

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ApexBio Technology

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BOC Sciences

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Cayman Chemical Company

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International Laboratory Limited

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View Lastest Price from BMS-687453 manufacturers

Career Henan Chemical Co

Product: 2-[[3-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl-methoxycarbonylamino]acetic acid 1000998-59-3
Price: US $1.00/KG
Min. Order: 1g
Purity: Min98% HPLC
Supply Ability: g/kg /ton
Release date: 2019-12-20

1000998-59-3, BMS-687453Related Search:

BMS-687453

N-[[3-[[2-(4-Chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)glycine

N-(3-{[2-(4-Chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyl)-N-(methoxycarbonyl)glycine

2-[[3-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl-methoxycarbonylamino]acetic acid

CS-1533

BMS-687453;BMS687453;BMS 687453

Glycine, N-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)-

BMS-687453,PPAR,Peroxisome proliferator-activated receptors,Inhibitor,BMS687453,inhibit,BMS 687453

1000998-59-3