CEP-32496 (free base)

ChemicalBook > CAS DataBase List > CEP-32496 (free base)

Product Name: CEP-32496 (free base)
CAS No.: 1188910-76-0
Chemical Name: CEP-32496 (free base)
Synonyms: CS-1683;AC013773;RXDX-105;AC 013773;Agerafenib;RXDX-105 (CEP-32496);CEP-32496 (free base);AC-013773. Agerafenib;Agerafenib (RXDX-105);Agerafenib (CEP-32496)
CBNumber: CB12627682
Molecular Formula: C24H22F3N5O5
Formula Weight: 517.46
MOL File: 1188910-76-0.mol

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CEP-32496 (free base) Property

storage temp.: Store at -20°C
solubility: ≥25.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: A crystalline solid
color: White to off-white
CAS DataBase Reference: 1188910-76-0

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18776
Product name: CEP-32496
Purity: ≥95%
Packaging: 500μg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18776
Product name: CEP-32496
Purity: ≥95%
Packaging: 1mg
Price: $74
Updated: 2024/03/01

Cayman Chemical

Product number: 18776
Product name: CEP-32496
Purity: ≥95%
Packaging: 5mg
Price: $299
Updated: 2024/03/01

Cayman Chemical

Product number: 18776
Product name: CEP-32496
Purity: ≥95%
Packaging: 10mg
Price: $381
Updated: 2024/03/01

TRC

Product number: C256660
Product name: CEP32496
Packaging: 75mg
Price: $1460
Updated: 2021/12/16

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CEP-32496 (free base) Chemical Properties,Usage,Production

Description

B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. Mutations of B-Raf, particularly at Val⁶⁰⁰, are common in melanomas and melanocytic nevi. CEP-32496 is a potent inhibitor of B-Raf^V600E (K_d = 14 nM in an in vitro binding assay). It blocks B-Raf^V600E-dependent phosphorylation of MEK in human melanoma A375 and colorectal cancer COLO 205 cells (IC₅₀s = 78 and 60 nM, respectively). CEP-32496 binds kinases other than B-Raf but displays selective cytotoxicity for cells expressing B-Raf^V600E. It displays good oral bioavailability in rats, dogs, and monkeys and has single oral dose pharmacodynamics inhibition of both pMEK and pERK in B-Raf^V600E colon carcinoma xenografts in nude mice.

Uses

CEP 32496 is an orally active BRAFV600E inhibitor with selective cellular and in vivo antitumor activity.

References

[1] rowbottom mw1, faraoni r, chao q, campbell bt, lai ag, setti e, ezawa m, sprankle kg, abraham s, tran l, struss b, gibney m, armstrong rc,gunawardane rn, nepomuceno rr, valenta i, hua h, gardner mf, cramer md, gitnick d, insko de, apuy jl, jones-bolin s, ghose ak, herbertz t, ator ma,dorsey bd, ruggeri b, williams m, bhagwat s, james j, holladay mw. identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2 -methylpropan- 2-yl) isoxazol-3-yl) urea hydrochloride (cep-32496), a highly potent and orally efficacious inhibitor of v-raf murine sarcoma viral oncogene homologue b1 (braf) v600e. j med chem. 2012 feb 9;55(3):1082-105. doi: 10.1021/jm2009925. epub 2012 jan 23.

CEP-32496 (free base) Preparation Products And Raw materials

Raw materials

Preparation Products

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CEP-32496 (free base) Suppliers

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View Lastest Price from CEP-32496 (free base) manufacturers

Career Henan Chemical Co

Product: CEP-32496 (free base) 1188910-76-0
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2019-12-24

1188910-76-0, CEP-32496 (free base)Related Search:

SB590885

CEP-32496 (free base)

1-[3-[(6,7-Dimethoxyquinazolin-4-yl)oxy]phenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl]urea

Urea, N-[3-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-

AC 013773

AC013773

AC-013773. Agerafenib

CEP-32496 FREE BASE;AC013773; AC 013773; AC-013773. AGERAFENIB

1-[3-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea

Agerafenib (CEP-32496)

CEP-32496;CEP 32496;CEP32496

CS-1683

Agerafenib

RXDX-105

RXDX-105 (CEP-32496)

CEP-32496 CEP32496 Agerafenib RXDX-105 RXDX105

Agerafenib (RXDX-105)

Agerafenib, 10 mM in DMSO

1188910-76-0

188910-76-0

Inhibitors

MAPK