DWK-1339
- Product Name
- DWK-1339
- CAS No.
- 1018946-38-7
- Chemical Name
- DWK-1339
- Synonyms
- SNU-0039;DWK-1339;SNU-0039 (DWK-133);DWK-1339;DWK 1339;DWK1339;2-(3,4-dimethoxyphenyl)-5-(3-methoxypropyl)-1-benzofuran;Benzofuran, 2-(3,4-diMethoxyphenyl)-5-(3-Methoxypropyl)-;2-(3,4-DiMethoxy-phenyl)-5-(3-Methoxy-propyl)-benzofuran;MDR1339,DWK1339,inhibit,β-amyloid peptide,Inhibitor,MDR 1339,Abeta,Amyloid-β,MDR-1339,DWK 1339
- CBNumber
- CB12627783
- Molecular Formula
- C20H22O4
- Formula Weight
- 326.39
- MOL File
- 1018946-38-7.mol
DWK-1339 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 30mg/mL; DMSO: 30mg/mL; Ethanol: 2mg/mL
- form
- A crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 27642
- Product name
- DWK-1339
- Packaging
- 500μg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 27642
- Product name
- DWK-1339
- Packaging
- 5mg
- Price
- $722
- Updated
- 2024/03/01
- Product number
- 27642
- Product name
- DWK-1339
- Packaging
- 1mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- D103595
- Product name
- DWK-1339
- Packaging
- 1mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- CS-0003407
- Product name
- MDR-1339
- Purity
- 98.03%
- Packaging
- 25mg
- Price
- $560
- Updated
- 2021/12/16
DWK-1339 Chemical Properties,Usage,Production
Description
DWK-1339 is an inhibitor of amyloid-β (Aβ) aggregation. It inhibits aggregation of monomeric Aβ (1-42) (Aβ42) and induces disaggregation of Aβ42 fibrils in vitro when used at concentrations ranging from 3.1 to 50 μM. DWK-1339 (10 μM) reduces Aβ42-induced toxicity in HT-22 cells. In vivo, DWK-1339 (10 mg/kg) increases step-through latency in a passive avoidance test and increases spontaneous alteration in the Y-maze compared with vehicle control mice in a mouse model of Aβ42-induced acute Alzheimer''s disease. It also decreases brain levels of Aβ42 and increases spontaneous alteration in the Y-maze in the APP/PS1 transgenic mouse model of Alzheimer''s disease.
Uses
DWK-1339, is an orally active and blood-brain-barrier-permeable Aβ-aggregation inhibitor, used in the research of Alzheimer''s disease.
DWK-1339 Preparation Products And Raw materials
Raw materials
Preparation Products
DWK-1339 Suppliers
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