ELR-510444
- Product Name
- ELR-510444
- CAS No.
- 1233948-35-0
- Chemical Name
- ELR-510444
- Synonyms
- CS-1765;LR-510444;ELR-510444;ELR510444, >95%;ELR-510444;ELR510444;N-[5-(5-Cyano-2-thienyl)-2-methylphenyl]-4-methylbenzenesulfonamide;Benzenesulfonamide, N-[5-(5-cyano-2-thienyl)-2-methylphenyl]-4-methyl-;N-(5-(5-cyanothiophen-2-yl)-2-Methylphenyl)-4-MethylbenzenesulfonaMide;N-(5-(5-cyanothiophen-2-yl)-2-methylphenyl)-4-methylbenzenesulfonamide ELR-510444
- CBNumber
- CB12627798
- Molecular Formula
- C19H16N2O2S2
- Formula Weight
- 368.47
- MOL File
- 1233948-35-0.mol
ELR-510444 Property
- Boiling point:
- 547.8±60.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥11.9 mg/mL in DMSO
- form
- solid
- pka
- 8.28±0.10(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
N-Bromosuccinimide Price
- Product number
- 17696
- Product name
- ELR510444
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 17696
- Product name
- ELR510444
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 17696
- Product name
- ELR510444
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $257
- Updated
- 2024/03/01
- Product number
- 17696
- Product name
- ELR510444
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $479
- Updated
- 2024/03/01
- Product number
- 8445DG
- Product name
- N-(5-(5-Cyanothiophen-2-yl)-2-methylphenyl)-4-methylbenzenesulfonamide
- Packaging
- 25mg
- Price
- $631
- Updated
- 2021/12/16
ELR-510444 Chemical Properties,Usage,Production
Description
ELR510444 is an inhibitor of tubulin polymerization (IC50 = 10 μM) that binds to tubulin at the colchicine binding site. It induces microtubule depolymerization in A-10 cells (EC50 = 21 nM). ELR510444 inhibits growth in a cancer cell line panel (IC50s = 9-43 nM) via formation of multiple spindles and induction of mitotic arrest. Oral administration of ELR510444 (3-6 mg/kg) reduces tumor size in an MDA-MB-231 breast cancer mouse xenograft model in a dose-dependent manner. ELR510444 also inhibits hypoxia-inducible factor 1α (HIF-1α) in RCC4 cells in a concentration-dependent manner.
in vitro
elr510444 has potent microtubuledisrupting activity, causing a loss of intracellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. elr510444 inhibited cell proliferation, inhibited the rate and extent of purified tubulin assembly potently, and displaced colchicine from tubulin, revealing that the drug directly interacts with tubulin at the colchicine-binding site [1].
in vivo
elr510444 also shows potent antitumor activity in the mda-mb-231 xenograft model with at least a 2-fold therapeutic window [1].
References
[1] risinger al, westbrook cd, encinas a, mülbaier m, schultes cm, wawro s, lewis jd, janssen b, giles fj, mooberry sl. elr510444, a novel microtubule disruptor with multiple mechanisms of action. j pharmacol exp ther. 2011 mar;336(3):652-60.
ELR-510444 Preparation Products And Raw materials
Raw materials
Preparation Products
ELR-510444 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from ELR-510444 manufacturers
- Product
- N-(5-(5-cyanothiophen-2-yl)-2-Methylphenyl)-4-MethylbenzenesulfonaMide 1233948-35-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20kg
- Release date
- 2019-09-05