ChemicalBook > CAS DataBase List > JI-101

JI-101

Product Name
JI-101
CAS No.
900573-88-8
Chemical Name
JI-101
Synonyms
JI-101;CS-2268;CGI 1842;JI101;JI 101;JI-101, 10 mM in DMSO;Pazopanib Impurity 66;1-[1-[(2-Aminopyridin-4-yl)methyl]-1H-indol-4-yl]-3-(5-bromo-2-methoxyphenyl)urea;Urea, N-[1-[(2-amino-4-pyridinyl)methyl]-1H-indol-4-yl]-N'-(5-bromo-2-methoxyphenyl)-;5-amino-2-methyl-N-(4-methyl-3-(N-(4-methyl-3-sulfamoylphenyl)sulfamoyl)phenyl)benzenesulfonamide;Inhibitor,Vascular endothelial growth factor receptor,JI-101,Ephrin Receptor,PDGFR,JI101,VEGFR,Platelet-derived growth factor receptor,inhibit
CBNumber
CB12627990
Molecular Formula
C22H20BrN5O2
Formula Weight
466.33
MOL File
900573-88-8.mol
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JI-101 Property

Boiling point:
606.9±55.0 °C(Predicted)
Density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
13.25±0.70(Predicted)
color 
Pale Brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
J210340
Product name
JI-​101
Packaging
10mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-5636
Product name
JI-101
Purity
99.95%
Packaging
10mg
Price
$228
Updated
2021/12/16
ChemScene
Product number
CS-5636
Product name
JI-101
Purity
99.95%
Packaging
50mg
Price
$792
Updated
2021/12/16
ChemScene
Product number
CS-5636
Product name
JI-101
Purity
99.95%
Packaging
100mg
Price
$1320
Updated
2021/12/16
ChemScene
Product number
CS-5636
Product name
JI-101
Purity
99.95%
Packaging
5mg
Price
$156
Updated
2021/12/16
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JI-101 Chemical Properties,Usage,Production

Uses

JI-?101 is VEGFR2 inhibitor. It can be used as analyte in pharmacological activity and analytical study of assay methodologies and perspectives for quantitation of VEGFR2 inhibitors such as sunitinib, sorafenib, pazopanib and JI-101 which were involved in treatment of cancer in human and animal models including mouse.

in vivo

JI-101excreted through bile along with its mono- and di-hydroxy metabolites. Following oral administration, JI-101 is rapidly absorbed, reaching Cmax within 2?h. The t1/2 of JI-101 with intravenous and oral route is found to be 1.75±0.79 and 2.66±0.13?h, respectively. The Cl and Vd by intravenous route for JI-101 are found to be 13.0±2.62?mL/min/kg and 2.11±1.42?L/kg, respectively. The tissue distribution of JI-101 is extensive with rapid and preferred uptake into lung tissue. Overall, the oral bioavailability of JI-101 is 55% and the primary route of elimination for JI-101 is feces[1].

IC 50

VEGFR2; PDGFRβ

JI-101 Preparation Products And Raw materials

Raw materials

Preparation Products

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JI-101 Suppliers

China 51 India 1 United States 9 Global 61
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

900573-88-8, JI-101Related Search:

Pazopanib Impurity 23 1821666-74-3 Pazopanib Impurity 3

  • JI-101
  • CGI 1842
  • 1-[1-[(2-Aminopyridin-4-yl)methyl]-1H-indol-4-yl]-3-(5-bromo-2-methoxyphenyl)urea
  • CS-2268
  • JI101;JI 101
  • Urea, N-[1-[(2-amino-4-pyridinyl)methyl]-1H-indol-4-yl]-N'-(5-bromo-2-methoxyphenyl)-
  • Pazopanib Impurity 66
  • Inhibitor,Vascular endothelial growth factor receptor,JI-101,Ephrin Receptor,PDGFR,JI101,VEGFR,Platelet-derived growth factor receptor,inhibit
  • 5-amino-2-methyl-N-(4-methyl-3-(N-(4-methyl-3-sulfamoylphenyl)sulfamoyl)phenyl)benzenesulfonamide
  • JI-101, 10 mM in DMSO
  • 900573-88-8