N4-isobutyl-N2-((2-phenylthiazol-4-yl)Methyl)pyriMidine-2,4-diaMine

Product Name: N4-isobutyl-N2-((2-phenylthiazol-4-yl)Methyl)pyriMidine-2,4-diaMine
CAS No.: 1262770-73-9
Chemical Name: N4-isobutyl-N2-((2-phenylthiazol-4-yl)Methyl)pyriMidine-2,4-diaMine
Synonyms: KHS101;KHS101 HCI;KHS101 hcl;KHS-101 (KHS101);KHS-101;KHS101;KHS 101;Neurogenesis Inducer V, KHS101;N4-isobutyl-N2-((2-phenylthiazol-4-yl)Methyl)pyriMidine-2,4-diaMine;2,4-Pyrimidinediamine, N4-(2-methylpropyl)-N2-[(2-phenyl-4-thiazolyl)methyl]-;N4-(2-Methylpropyl)-N2-[(2-phenyl-1,3-thiazol-4-yl)methyl]pyrimidine-2,4-diamine;4-N-(2-methylpropyl)-2-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]pyrimidine-2,4-diamine
CBNumber: CB12628179
Molecular Formula: C18H21N5S
Formula Weight: 339.46
MOL File: 1262770-73-9.mol

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N4-isobutyl-N2-((2-phenylthiazol-4-yl)Methyl)pyriMidine-2,4-diaMine Property

Boiling point:: 574.8±60.0 °C(Predicted)
Density: 1.241±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 100mg/mL
pka: 5.76±0.10(Predicted)
form: resin (Sticky)
color: yellow
InChI: 1S/C18H21N5S/c1-13(2)10-20-16-8-9-19-18(23-16)21-11-15-12-24-17(22-15)14-6-4-3-5-7-14/h3-9,12-13H,10-11H2,1-2H3,(H2,19,20,21,23)
InChIKey: DGRJOOOHPBSAHD-UHFFFAOYSA-N
SMILES: [s]1c(nc(c1)CNc3nc(ccn3)NCC(C)C)c2ccccc2

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
WGK Germany: WGK 2
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 480747
Product name: Neurogenesis Inducer V, KHS101
Purity: A blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of AR
Packaging: 10 mg
Price: $170
Updated: 2026/03/19

Sigma-Aldrich

Product number: K4019
Product name: KHS101
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $150
Updated: 2022/05/15

Biorbyt Ltd

Product number: orb573181
Product name: KHS-101
Purity: >98%
Packaging: 100mg
Price: $838.1
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573181
Product name: KHS-101
Purity: >98%
Packaging: 250mg
Price: $1431.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573181
Product name: KHS-101
Purity: >98%
Packaging: 1g
Price: $2691.1
Updated: 2021/12/16

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N4-isobutyl-N2-((2-phenylthiazol-4-yl)Methyl)pyriMidine-2,4-diaMine Chemical Properties,Usage,Production

Uses

KHS101 is a small molecule that accelerates neuronal differentiation. KHS101 can distributes to the brain and resulted in a significant increase in neuronal differentiation[1].

in vivo

KHS101 (6 mg/kg; s.c.; BID for 14 days) distributes to the brain and significantly increases neuronal differentiation in rats in vivo^[1].

Animal Model:	Adult Fisher 344 rats (～10 wk old)^[1]
Dosage:	6 mg/kg
Administration:	SC, BID for 14 days
Result:	Increased neuronal differentiation. Reduced proliferation of NPCs.

References

[1] Wurdak H, et al. A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16542-7. DOI:10.1073/pnas.1010300107

N4-isobutyl-N2-((2-phenylthiazol-4-yl)Methyl)pyriMidine-2,4-diaMine Preparation Products And Raw materials

Raw materials

Preparation Products

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N4-isobutyl-N2-((2-phenylthiazol-4-yl)Methyl)pyriMidine-2,4-diaMine Suppliers

China 28 United States 4 Global 32

Shanghai Lollane Biological Technology Co.,Ltd.

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View Lastest Price from N4-isobutyl-N2-((2-phenylthiazol-4-yl)Methyl)pyriMidine-2,4-diaMine manufacturers

Career Henan Chemical Co

Product: N4-isobutyl-N2-((2-phenylthiazol-4-yl)Methyl)pyriMidine-2,4-diaMine 1262770-73-9
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

1262770-73-9, N4-isobutyl-N2-((2-phenylthiazol-4-yl)Methyl)pyriMidine-2,4-diaMineRelated Search:

KHS101 hcl

KHS-101 (KHS101)

KHS-101;KHS101;KHS 101

N4-isobutyl-N2-((2-phenylthiazol-4-yl)Methyl)pyriMidine-2,4-diaMine

KHS101

N4-(2-Methylpropyl)-N2-[(2-phenyl-1,3-thiazol-4-yl)methyl]pyrimidine-2,4-diamine

4-N-(2-methylpropyl)-2-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]pyrimidine-2,4-diamine

2,4-Pyrimidinediamine, N4-(2-methylpropyl)-N2-[(2-phenyl-4-thiazolyl)methyl]-

KHS101 HCI

Neurogenesis Inducer V, KHS101

1262770-73-9