NS 11394

Product Name: NS 11394
CAS No.: 951650-22-9
Chemical Name: NS 11394
Synonyms: NS 11394;NS11394, >98%;NS 11394/NS11394;NS 11394;NS-11394;NS11394;2-[3-[5-(2-hydroxypropan-2-yl)benzimidazol-1-yl]phenyl]benzonitrile;3'-(5-(2-hydroxypropan-2-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-2-carbonitrile;3'-[5-(1-Hydroxy-1-methylethyl)-1H-benzimidazol-1-yl]-[1,1'-biphenyl]-2-carbonitrile;3'-(5-(2-Hydroxypropan-2-yl)-1H-benzo[d]imidazol-1-yl)-[1,1'-biphenyl]-2-carbonitrile;[1,1'-Biphenyl]-2-carbonitrile, 3'-[5-(1-hydroxy-1-methylethyl)-1H-benzimidazol-1-yl]-;Inhibitor,Anxiety,cord,NS11394,γ-Aminobutyric acid Receptor,neuropathi,electrophysiological,Freund’s,inhibit,Complete,pain,NS-11394,Gamma-aminobutyric acid Receptor,adjuvant,inflammatory,pinal,GABA Receptor
CBNumber: CB12628199
Molecular Formula: C23H19N3O
Formula Weight: 353.42
MOL File: 951650-22-9.mol

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NS 11394 Property

Boiling point:: 623.7±65.0 °C(Predicted)
Density: 1.17
storage temp.: Store at -20°C
solubility: ≥35.3 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥11.02 mg/mL in EtOH
form: solid
pka: 14.20±0.29(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23872
Product name: NS 11394
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23872
Product name: NS 11394
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 23872
Product name: NS 11394
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 23872
Product name: NS 11394
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

ChemScene

Product number: CS-3883
Product name: NS11394
Purity: 99.84%
Packaging: 50mg
Price: $550
Updated: 2021/12/16

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NS 11394 Chemical Properties,Usage,Production

Biological Activity

ns 11394 is a selective gaba(a) receptor-positive modulator.preclinical studies suggest that gabaa-1, 2, and 5-containing receptors can mediate the sedative/ motor-impairing, anxiolytic, and memory impairing effects, respectively.

in vitro

previous study showed that ns11394 possessed a functional selectivity profile at gaba(a) receptors of alpha(5) > alpha(3) > alpha(2) > alpha(1) based on oocyte electrophysiology with human gaba(a) receptors. moreover, compared with other subtype-selective ligands, ns11394 was unique in having superior efficacy for gaba(a)-alpha(3) receptors while maintaining low efficacy for gaba(a)-alpha(1) receptors [1].

in vivo

animal study showed that ns11394 had an excellent pk profile, which correlated with pharmacodynamic endpoints of cns receptor occupancy. in addition, it was showd that ns11394 was potent and highly effective in rodent anxiety models. the anxiolytic efficacy of ns11394 was most probably mediated via its high efficacy at gaba(a)-alpha(3) receptors, though the contribution of gaba(a)-alpha(2) receptors could not be excluded. moreover, when compared with benzodiazepines, ns11394 had a significantly reduced side effect profile in rat and mouse, even at full cns receptor occupancy. the authors attributed such benign side effect profile to very low efficacy of ns11394 at gaba(a)-alpha(1) receptors and a partial agonist profile of receptor subtypes. it was also found that ns11394 could impair memory in both rats and mice, which was possibly attributable to its efficacy at gaba(a)-alpha(5) receptors [1].

References

[1] mirza nr, et al. ns11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl- 2-carbonitrile], a unique subtype-selective gabaa receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy. j pharmacol exp ther. 2008 dec;327(3):954-68.

NS 11394 Preparation Products And Raw materials

Raw materials

Preparation Products

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NS 11394 Suppliers

China 47 United Kingdom 1 United States 9 Global 57

Target molecule Corp.

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951650-22-9, NS 11394Related Search:

NS 1619 Selexipag 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole NS-6180 2-HYDROXYETHYLUREA Methylcyclohexane 2-(2-Aminoethylamino)ethanol

NS 11394

3'-[5-(1-Hydroxy-1-methylethyl)-1H-benzimidazol-1-yl]-[1,1'-biphenyl]-2-carbonitrile

3'-(5-(2-hydroxypropan-2-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-2-carbonitrile

2-[3-[5-(2-hydroxypropan-2-yl)benzimidazol-1-yl]phenyl]benzonitrile

NS 11394;NS-11394;NS11394

NS11394, >98%

Inhibitor,Anxiety,cord,NS11394,γ-Aminobutyric acid Receptor,neuropathi,electrophysiological,Freund’s,inhibit,Complete,pain,NS-11394,Gamma-aminobutyric acid Receptor,adjuvant,inflammatory,pinal,GABA Receptor

NS 11394/NS11394

[1,1'-Biphenyl]-2-carbonitrile, 3'-[5-(1-hydroxy-1-methylethyl)-1H-benzimidazol-1-yl]-

3'-(5-(2-Hydroxypropan-2-yl)-1H-benzo[d]imidazol-1-yl)-[1,1'-biphenyl]-2-carbonitrile

951650-22-9

Inhibitors