1-BOC-5-Methyl-3-pyrrolidinone

Product Name: 1-BOC-5-Methyl-3-pyrrolidinone
CAS No.: 362706-25-0
Chemical Name: 1-BOC-5-Methyl-3-pyrrolidinone
Synonyms: 1-BOC-5-Methyl-3-pyrrolidinone;1-Boc-2-methyl-4-oxopyrrolidine;tert-Butyl 2-Methyl-4-oxopyrrolidine-1-carboxylate;2-Methyl-4-oxo-1-pyrrolidinecarboxylic acid tert-butyl ester;2-methyl-4-oxo-1-Pyrrolidinecarboxylic acid 1,1-dimethylethyl ester;1-Pyrrolidinecarboxylic acid, 2-methyl-4-oxo-, 1,1-dimethylethyl ester
CBNumber: CB12630772
Molecular Formula: C10H17NO3
Formula Weight: 199.25
MOL File: 362706-25-0.mol

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1-BOC-5-Methyl-3-pyrrolidinone Property

Boiling point:: 280℃
Density: 1.086
Flash point:: 123℃
storage temp.: 2-8°C
pka: -1.72±0.40(Predicted)
Appearance: Light brown to brown Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B814408
Product name: tert-Butyl2-methyl-4-oxopyrrolidine-1-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: 4600AB
Product name: tert-Butyl2-methyl-4-oxopyrrolidine-1-carboxylate
Packaging: 250mg
Price: $286
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0393964
Product name: TERT-BUTYL-2-METHYL-4-OXOPYRROLIDINE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $502.51
Updated: 2021/12/16

Abosyn

Product number: 10-2329
Product name: tert-butyl2-methyl-4-oxopyrrolidine-1-carboxylate
Purity: 95%-98%
Packaging: 1g
Price: $796
Updated: 2021/12/16

Ambeed

Product number: A249642
Product name: tert-Butyl2-methyl-4-oxopyrrolidine-1-carboxylate
Purity: 98%
Packaging: 5g
Price: $1460
Updated: 2021/12/16

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1-BOC-5-Methyl-3-pyrrolidinone Chemical Properties,Usage,Production

Synthesis

23770-07-2

24424-99-5

362706-25-0

Step 5: Synthesis of tert-butyl 5-methyl-(pyrrolidin-3-one)-1-carboxylate 1-Benzyl-5-methylpyrrolidin-3-one (2 g, 10.57 mmol) and di-tert-butyl dicarbonate (Boc2O, 2.77 g, 12.98 mmol) were dissolved in ethanol (EtOH, 20 mL) and palladium/carbon (Pd/C, 0.3 g) was added as a catalyst. The reaction mixture was stirred overnight under hydrogen (H2, 40 psi) atmosphere. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated. The residue was purified by column chromatography (eluent ratio petroleum ether/ethyl acetate = 9:1) to afford tert-butyl 5-methyl-(pyrrolidin-3-one)-1-carboxylate (1.4 g, 66.5% yield) as a colorless oil. Product characterization data: 1H NMR (400 MHz, CDCl3) δ ppm 7.33-7.23 (m, 5H), 4.18-4.15 (d, J=13.2 Hz, 1H), 3.29-3.14 (m, 1H), 2.99-2.93 (m, 1H), 2.65-2.60 (m, 1H), 2.51-2.45 (m , 1H), 2.16-2.08 (m, 1H), 1.34-1.32 (m, 3H); no ionization signal was detected by ES-LCMS.

References

[1] Patent: WO2010/141539, 2010, A1. Location in patent: Page/Page column 24-25
[2] Patent: US2002/13341, 2002, A1

1-BOC-5-Methyl-3-pyrrolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BOC-5-Methyl-3-pyrrolidinone Suppliers

China 53 United States 3 Global 56

Shanghai Topbiochem Technology Co., Ltd

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Amadis Chemical Company Limited

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Hangzhou Molcore Biopharmatech Co.,Ltd

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View Lastest Price from 1-BOC-5-Methyl-3-pyrrolidinone manufacturers

Career Henan Chemical Co

Product: 1-BOC-5-Methyl-3-pyrrolidinone 362706-25-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-30

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362706-25-0