1,4-DibroMo-2-fluoro-5-nitrobenzene
Application- Product Name
- 1,4-DibroMo-2-fluoro-5-nitrobenzene
- CAS No.
- 366496-33-5
- Chemical Name
- 1,4-DibroMo-2-fluoro-5-nitrobenzene
- Synonyms
- 2,5-Dibromo-4-fluoronitrobenzene;1,4-DibroMo-2-fluoro-5-nitrobenzene;Benzene, 1,4-dibromo-2-fluoro-5-nitro-
- CBNumber
- CB12630792
- Molecular Formula
- C6H2Br2FNO2
- Formula Weight
- 298.89
- MOL File
- 366496-33-5.mol
1,4-DibroMo-2-fluoro-5-nitrobenzene Property
- Boiling point:
- 265℃
- Density
- 2.168
- Flash point:
- 114℃
- storage temp.
- 2-8°C
- Appearance
- Light yellow to yellow Solid
- CAS DataBase Reference
- 366496-33-5
Safety
- HS Code
- 2904909090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D426280
- Product name
- 1,4-Dibromo-2-fluoro-5-nitrobenzene
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 6481DP
- Product name
- 1,4-Dibromo-2-fluoro-5-nitrobenzene
- Packaging
- 100g
- Price
- $222
- Updated
- 2021/12/16
- Product number
- 366496335
- Product name
- 1,4-Dibromo-2-fluoro-5-nitrobenzene
- Packaging
- 250mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- 366496335
- Product name
- 1,4-Dibromo-2-fluoro-5-nitrobenzene
- Packaging
- 500mg
- Price
- $839.45
- Updated
- 2021/12/16
- Product number
- 366496335
- Product name
- 1,4-Dibromo-2-fluoro-5-nitrobenzene
- Packaging
- 1g
- Price
- $1534.7
- Updated
- 2021/12/16
1,4-DibroMo-2-fluoro-5-nitrobenzene Chemical Properties,Usage,Production
Application
1,4-Dibromo-2-fluoro-5-nitrobenzene is an organic intermediate that can be obtained from 1,4-dibromo-2-fluoro-5-nitrobenzene via a one-step reaction or from 4-bromo-5-fluoro-2-nitrobenzene via a diazotization reaction. It can be used as an organic synthesis intermediate and a pharmaceutical intermediate in laboratory research and development and chemical production processes.
Synthesis
153505-36-3
366496-33-5
General procedure for the synthesis of 1,4-dibromo-2-fluoro-5-nitrobenzene from 4-bromo-5-fluoro-2-nitroaniline: copper(II) bromide (6.37 g, 28.5 mmol) was dissolved in acetonitrile (40 mL) under stirring conditions. N-butyl nitrite (5.0 mL, 42 mmol) was added slowly via syringe and the reaction system was subsequently heated to 60 °C. 4-Bromo-5-fluoro-2-nitroaniline (4.46 g, 19.0 mmol) was dissolved in acetonitrile (60 mL) and slowly added dropwise to the reaction system via a dosing funnel over 15 minutes. The reaction continued to be stirred for 10 min and then cooled to room temperature. The reaction mixture was poured into 2N aqueous hydrochloric acid (400 mL) and extracted with ether. The organic layer was washed with brine and the combined aqueous layers were then extracted with ethyl acetate. All organic layers were combined, dried with anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure by rotary evaporator. Finally, the target product 1,4-dibromo-2-fluoro-5-nitrobenzene was purified by fast column chromatography to give 4.46 g in 76% yield.1H NMR (300 MHz, DMSO-d6): δ 8.59 (d, 1H, J = 6.5 Hz), 8.17 (d, 1H, J = 8.1 Hz).
References
[1] Tetrahedron Letters, 2008, vol. 49, # 44, p. 6348 - 6351
[2] Patent: WO2007/30366, 2007, A1. Location in patent: Page/Page column 121-122
1,4-DibroMo-2-fluoro-5-nitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,4-DibroMo-2-fluoro-5-nitrobenzene manufacturers
- Product
- 1,4-DibroMo-2-fluoro-5-nitrobenzene 366496-33-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-16