1H-Pyrazole, 1-(tetrahydro-3-furanyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- Product Name
- 1H-Pyrazole, 1-(tetrahydro-3-furanyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CAS No.
- 1029715-63-6
- Chemical Name
- 1H-Pyrazole, 1-(tetrahydro-3-furanyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- Synonyms
- 1-(Oxolan-3-yl)-1H-pyrazole-4-boronic acid pinacol ester;1-(3-Tetrahydrofuryl)-1H-pyrazole-4-boronic acid pinacol ester;1-[3-(Tetrahydrofuryl)-1H-pyrazole-4-boronic acid pinacol es...;1-(oxolan-3-yl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-(oxolan-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-(Oxolan-3-yl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 95+%;1-(3-Tetrahydrofuryl)-1H-pyrazole-4-boronic acid pinacol ester - [T11813];1-Tetrahydrofuran-3-yl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol;1-Tetrahydrofuran-3-yl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-(tetrahydrofuran-3-yl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
- CBNumber
- CB12631931
- Molecular Formula
- C13H21BN2O3
- Formula Weight
- 264.13
- MOL File
- 1029715-63-6.mol
1H-Pyrazole, 1-(tetrahydro-3-furanyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- Property
- Boiling point:
- 399.3±32.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.63±0.19(Predicted)
- Appearance
- Off-white to pink Solid
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E588815
- Product name
- 1-(Oxolan-3-yl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
- Packaging
- 1g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 8H60-1-8Z
- Product name
- 1-(3-Tetrahydrofuryl)-1H-pyrazole-4-boronic acid, pinacol ester
- Packaging
- 5G
- Price
- $750
- Updated
- 2021/12/16
- Product number
- 113284
- Product name
- 1-(3-Tetrahydrofuryl)-1H-pyrazole-4-boronic acid pinacol ester
- Packaging
- 1g
- Price
- $851
- Updated
- 2021/12/16
- Product number
- CS-W020669
- Product name
- 1-(Tetrahydrofuran-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
- Purity
- >97.0%
- Packaging
- 250mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- OR361685
- Product name
- 1-(Oxolan-3-yl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
1H-Pyrazole, 1-(tetrahydro-3-furanyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- Chemical Properties,Usage,Production
Synthesis
1040377-07-8
73183-34-3
1029715-63-6
Potassium acetate (KOAc, 1.07 g, 10.92 mmol) was added to a solution of 4-bromo-1-(tetrahydrofuran-3-yl)-1H-pyrazole (0.79 g, 3.64 mmol) and pinacol ester of bis(boronic acid) (1.11 g, 4.37 mmol) in N,N-dimethylformamide (DMF, 20 mL). The reaction mixture was degassed with nitrogen (N2) and stirred for 10 min, followed by the addition of [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride (Pd(dppf)Cl2, 89 mg, 0.109 mmol). After degassing again with nitrogen, the reaction mixture was stirred at 80 °C overnight. After completion of the reaction, DMF was removed by rotary evaporation and the residue was purified by column chromatography (eluent ratio: ethyl acetate:petroleum ether = 1:10) to afford 1-(tetrahydrofuran-3-yl)-1H-pyrazole-4-boronic acid pinacol ester (0.63 g, 65.6% yield).
References
[1] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 46
1H-Pyrazole, 1-(tetrahydro-3-furanyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- Preparation Products And Raw materials
Raw materials
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View Lastest Price from 1H-Pyrazole, 1-(tetrahydro-3-furanyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- manufacturers
- Product
- 1H-Pyrazole, 1-(tetrahydro-3-furanyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 1029715-63-6
- Price
- US $34.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 1-(3-Tetrahydrofuryl)-1H-... 1029715-63-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19