2-PiperidineMethanol, (2S)-
- Product Name
- 2-PiperidineMethanol, (2S)-
- CAS No.
- 41373-39-1
- Chemical Name
- 2-PiperidineMethanol, (2S)-
- Synonyms
- (S)-Piperidin-2-ylMethanol;[(2S)-2-piperidyl]methanol;(S)-2-Piperidinemethanol;(2S)-2-Piperidinemethanol;2-PiperidineMethanol, (2S)-;[(2S)-piperidin-2-yl]methanol;(2S)-2-PiperidineMethanol HCl
- CBNumber
- CB12639124
- Molecular Formula
- C6H13NO
- Formula Weight
- 115.17
- MOL File
- 41373-39-1.mol
2-PiperidineMethanol, (2S)- Property
- Melting point:
- 66-68 °C
- Boiling point:
- 221.2±0.0 °C(Predicted)
- Density
- 0.951±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 15.08±0.10(Predicted)
- Appearance
- Colorless to light yellow <66°C Solid,>68°C Liquid
- optical activity
- 16.267° (C=0.01 g/ml, ETOH)
- InChI
- InChI=1S/C6H13NO/c8-5-6-3-1-2-4-7-6/h6-8H,1-5H2/t6-/m0/s1
- InChIKey
- PRAYXGYYVXRDDW-LURJTMIESA-N
- SMILES
- N1CCCC[C@H]1CO
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P482660
- Product name
- (2S)-2-Piperidinemethanol
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR917897
- Product name
- (2S)-Piperidin-2-ylmethanol
- Purity
- 97%
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- CS-W001568
- Product name
- (S)-Piperidin-2-ylmethanol
- Packaging
- 5g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CCH0031961
- Product name
- ((S)-PIPERIDIN-2-YL)METHANOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $253.05
- Updated
- 2021/12/16
- Product number
- AS14582
- Product name
- (2S)-2-Piperidinemethanol HCl
- Purity
- 97+% ee
- Packaging
- 5G
- Price
- $260
- Updated
- 2021/12/16
2-PiperidineMethanol, (2S)- Chemical Properties,Usage,Production
Synthesis
3105-95-1
41373-39-1
General procedure for the synthesis of (S)-piperidin-2-ylmethanol from L-2-piperidinic acid: BH3-DMS (62.0 mmol, 4.0 eq.) and BF3-Et2O (15.5 mmol, 1.0 eq.) were added to a solution of (2S)-piperidine-2-carboxylic acid (15.5 mmol, 1.0 eq.) in THF (50 ml) at 0 °C. The reaction mixture was refluxed for 14 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure, followed by slow dropwise addition of MeOH (40 ml) at 0 °C. Concentrated HCl (5 ml) was added to the mixture and refluxing was continued for 2 hours. The solvent was again concentrated to remove the solvent and the residue was stirred in a DCM solution of 10% isopropanol for 15 min and filtered. The filtrate was concentrated to dryness to give the white solid product (S)-piperidin-2-ylmethanol in 80% yield.
References
[1] Tetrahedron, 2013, vol. 69, # 51, p. 10876 - 10883
[2] Tetrahedron, 2013, vol. 69, # 30, p. 6129 - 6143
[3] Patent: US2010/173889, 2010, A1. Location in patent: Page/Page column 34
[4] Patent: US2009/253669, 2009, A1. Location in patent: Page/Page column 46-47
[5] Patent: US2009/264407, 2009, A1. Location in patent: Page/Page column 77
2-PiperidineMethanol, (2S)- Preparation Products And Raw materials
Raw materials
Preparation Products
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