(S)-5-ChloroMethyl-2-oxazolidinone

Product Name: (S)-5-ChloroMethyl-2-oxazolidinone
CAS No.: 169048-83-3
Chemical Name: (S)-5-ChloroMethyl-2-oxazolidinone
Synonyms: (S)-5-ChloroMethyl-2-oxazolidinone;(S)-5-(ChloroMethyl)oxazolidin-2-one;(5S)-5-(Chloromethyl)-2-oxazolidinone;2-Oxazolidinone, 5-(chloromethyl)-, (5S)-;(5S)-5-(Chloromethyl)-1,3-oxazolidin-2-one
CBNumber: CB12642643
Molecular Formula: C4H6ClNO2
Formula Weight: 135.55
MOL File: 169048-83-3.mol

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(S)-5-ChloroMethyl-2-oxazolidinone Property

Melting point:: 86℃
Boiling point:: 382.8±11.0 °C(Predicted)
Density: 1.294±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.09±0.40(Predicted)
Appearance: White to off-white Solid
optical activity: 15.2° (C=1.00 g/100ml, DCM)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 098137
Product name: (S)-5-(Chloromethyl)oxazolidin-2-one
Purity: 95+%
Packaging: 250mg
Price: $213
Updated: 2021/12/16

AK Scientific

Product number: 8648AA
Product name: (S)-5-(Chloromethyl)oxazolidin-2-one
Packaging: 5g
Price: $249
Updated: 2021/12/16

Matrix Scientific

Product number: 098137
Product name: (S)-5-(Chloromethyl)oxazolidin-2-one
Purity: 95+%
Packaging: 1g
Price: $471
Updated: 2021/12/16

Activate Scientific

Product number: AS41198
Product name: (S)-5-(Chloromethyl)oxazolidin-2-one
Purity: 95% ee
Packaging: 1g
Price: $499
Updated: 2021/12/16

Ambeed

Product number: A307649
Product name: (S)-5-(Chloromethyl)oxazolidin-2-one
Purity: 95%
Packaging: 250mg
Price: $15
Updated: 2021/12/16

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(S)-5-ChloroMethyl-2-oxazolidinone Chemical Properties,Usage,Production

Synthesis

590-28-3

67843-74-7

169048-83-3

Potassium cyanate (4.38 g, 53.5 mmol) was dissolved in 220 mL of water and (S)-(+)-epichlorohydrin (2.50 g, 27.0 mmol) was added slowly. The reaction mixture was stirred under reflux conditions for 15 hours. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (5 x 200 mL) while it was still moderately warm. All organic phases were combined, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to afford (S)-5-chloromethyl-2-oxazolidinone, initially as a wax, which was converted to an off-white solid (2.18 g, 60% yield) after drying overnight under vacuum.

References

[1] European Journal of Organic Chemistry, 2001, # 13, p. 2425 - 2433
[2] Patent: WO2008/156718, 2008, A1. Location in patent: Page/Page column 25-26
[3] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 3, p. 258 - 262
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 9, p. 2597 - 2600
[5] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 2, p. 892 - 905

(S)-5-ChloroMethyl-2-oxazolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-5-ChloroMethyl-2-oxazolidinone Suppliers

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169048-83-3, (S)-5-ChloroMethyl-2-oxazolidinoneRelated Search:

(S)-5-ChloroMethyl-2-oxazolidinone

(5S)-5-(Chloromethyl)-1,3-oxazolidin-2-one

(S)-5-(ChloroMethyl)oxazolidin-2-one

2-Oxazolidinone, 5-(chloromethyl)-, (5S)-

(5S)-5-(Chloromethyl)-2-oxazolidinone

169048-83-3