1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester
- Product Name
- 1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester
- CAS No.
- 942190-61-6
- Chemical Name
- 1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester
- Synonyms
- Methyl 1-Boc-3-hydroxypyrrolidine-3-carboxylate;1-Boc-3-hydroxypyrrolidine-3-carboxylic acid methyl ester;Methyl 1-Boc-3-hydroxypyrrolidine-3-carboxylate - [M12685];1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester;1-tert-Butyl 3-Methyl 3-hydroxypyrrolidine-1,3-dicarboxylate;1-O-tert-butyl 3-O-methyl 3-hydroxypyrrolidine-1,3-dicarboxylate;1,3-Pyrrolidinedicarboxylic acid,3-hydroxy-,1-(1,1-dimethylethyl) 3-methyl ester
- CBNumber
- CB12644430
- Molecular Formula
- C11H19NO5
- Formula Weight
- 245.27
- MOL File
- 942190-61-6.mol
1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester Property
- Melting point:
- 71 - 73°C
- Boiling point:
- 314.5±42.0 °C(Predicted)
- Density
- 1.226±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.57±0.20(Predicted)
- color
- Off-White to Pale Brown
- InChI
- InChI=1S/C11H19NO5/c1-10(2,3)17-9(14)12-6-5-11(15,7-12)8(13)16-4/h15H,5-7H2,1-4H3
- InChIKey
- ALAIMDFVDAWVMO-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(O)(C(OC)=O)C1
- CAS DataBase Reference
- 942190-61-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-W000700
- Product name
- 1-tert-Butyl3-methyl3-hydroxypyrrolidine-1,3-dicarboxylate
- Packaging
- 100mg
- Price
- $86
- Updated
- 2021/12/16
- Product number
- 1954AQ
- Product name
- 1-tert-Butyl3-methyl3-hydroxypyrrolidine-1,3-dicarboxylate
- Packaging
- 500mg
- Price
- $414.8
- Updated
- 2021/12/16
- Product number
- 123056
- Product name
- Methyl1-Boc-3-hydroxypyrrolidine-3-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $498
- Updated
- 2021/12/16
- Product number
- CHM0238237
- Product name
- 1-TERT-BUTYL-3-METHYL-3-HYDROXYPYRROLIDINE-1,3-DICARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.4
- Updated
- 2021/12/16
- Product number
- M12685
- Product name
- Methyl1-Boc-3-hydroxypyrrolidine-3-carboxylate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $1520
- Updated
- 2021/12/16
1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester Chemical Properties,Usage,Production
Uses
1-tert-Butyl-3-Methyl 3-Hydroxypyrrolidine-1,3-Dicarboxylate can be used as LRRK2 inhibitors to treat diseases in which LRRK2 kinase is involved.
Synthesis
67-56-1
24424-99-5
942190-61-6
A mixture of compound 2W (5.3 g, 25 mmol), methanol (50 ml) and dioxane solution of 4N HCl (10 ml) was placed in a sealed tube and the reaction was heated at 70°C overnight. Upon completion of the reaction, the reaction mixture was concentrated, followed by addition of tetrahydrofuran (20 ml), dichloromethane (50 ml), triethylamine (16 ml) and di-tert-butyl dicarbonate (11 g). The mixture was stirred at room temperature overnight and then concentrated. The concentrated residue was diluted with ether (200 ml) and washed with deionized water (100 ml). The organic layer was separated, dried with anhydrous sodium sulfate, filtered and concentrated again. Finally, the residue was purified by silica gel column chromatography using 1:1 (v/v) ethyl acetate/hexanes and 2:1 (v/v) ethyl acetate/hexanes sequentially as eluent to give the target product 3W (4.35 g, 71% yield).
References
[1] Patent: WO2007/70398, 2007, A1. Location in patent: Page/Page column 440
1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester manufacturers
- Product
- 1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester 942190-61-6
- Price
- US $280.00/G
- Min. Order
- 1G
- Purity
- 99%
- Supply Ability
- customise
- Release date
- 2018-08-01