Temsavir

ChemicalBook > CAS DataBase List > Temsavir

Product Name: Temsavir
CAS No.: 701213-36-7
Chemical Name: Temsavir
Synonyms: CS-1668;Temsavir;EOS-62215;BMS-626529;BMS 626529;BMS-626529, Temsavir;BMS 626529; BMS626529;Temsavir (BMS-626529);Foscarbidopa Impurity 13;(1R,2S,3R,6S,7S,10R)-10-ISOPROPYL-3,7-DIMETHYL-11-OXATRICYCLO[5.3.1.02,6]UNDECAN-3-OL
CBNumber: CB12645134
Molecular Formula: C24H23N7O4
Formula Weight: 473.48
MOL File: 701213-36-7.mol

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Temsavir Property

Melting point:: 263-265°C
Boiling point:: 787.6±70.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 10.92±0.40(Predicted)
color: Off-White to Pale Beige
InChI: InChI=1S/C24H23N7O4/c1-15-27-14-31(28-15)22-20-19(18(35-2)13-26-22)17(12-25-20)21(32)24(34)30-10-8-29(9-11-30)23(33)16-6-4-3-5-7-16/h3-7,12-14,25H,8-11H2,1-2H3
InChIKey: QRPZBKAMSFHVRW-UHFFFAOYSA-N
SMILES: C(N1CCN(C(=O)C2=CC=CC=C2)CC1)(=O)C(C1C2C(OC)=CN=C(N3C=NC(C)=N3)C=2NC=1)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18413
Product name: BMS 626529
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18413
Product name: BMS 626529
Purity: ≥98%
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 18413
Product name: BMS 626529
Purity: ≥98%
Packaging: 10mg
Price: $299
Updated: 2024/03/01

Cayman Chemical

Product number: 18413
Product name: BMS 626529
Purity: ≥98%
Packaging: 50mg
Price: $849
Updated: 2024/03/01

TRC

Product number: T017900
Product name: Temsavir
Packaging: 50mg
Price: $65
Updated: 2021/12/16

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Temsavir Chemical Properties,Usage,Production

Description

BMS 626529 is an inhibitor of HIV-1 attachment. It binds to non-ligand bound HIV-1 gp120 to inhibit HIV-1 interaction with host CD4⁺ T cells and subsequent HIV-1 binding and cell entry. BMS 626529 reduces infectivity of laboratory strains and clinical isolates of HIV-1 (EC₅₀s = 0.4-2,000 and 25-2,000 nM, respectively) with cytotoxic concentration (CC₅₀) values greater than 100 μM in a panel of mammalian cell lines.

Uses

Temsavir is a Fostemsavir (CAS# 864953-29-7) intermediate and an antiviral agent. It is an HIV-1 attachment inhibitor.

Uses

Temsavir is an FDA-approved HIV-1 adhesion inhibitor. It blocks the interaction of Env with CD4. This molecule also stabilises Env in a pre-fused 'closed' conformation, which is the preferred target of several broad-spectrum neutralising antibodies (bNAbs). temsavir treatment also reduces the ability of bNAbs to eliminate HIV-1 infected cells through antibody-dependent cellular cytotoxicity (ADCC). fostemsavir, a pre-drug of temsavir, was approved in the FDA on 2 July 2020 approved for the treatment of patients with multidrug-resistant HIV-1 infection.

brand name

BMS-626529

Biological Functions

Temsavir prevents the host cell receptor CD4 from interacting with Env by binding to the pocket under the gp120 β20-β21 ring of the Env subunit. It prevents viral entry and also stabilises Env in a 'closed' conformation^[3].

in vitro

the activity of bms-626529 is virus dependent, due to heterogeneity within gp120. bms-626529 had half-maximal effective concentration values of6 log10, with half-maximal effective concentration values in the low pm range against the most susceptible viruses. measurement of the binding affinity of bms-626529 for purified gp120 suggests that a contributory factor to its inhibitory potency may be a relatively long dissociative half-life [1].

target

HIV-1 subtype A envelope

References

[1] nowicka-sans b, gong yf, mcauliffe b, dicker i, ho ht, zhou n, eggers b, lin pf, ray n, wind-rotolo m, zhu l, majumdar a, stock d, lataillade m, hanna gj, matiskella jd, ueda y, wang t, kadow jf, meanwell na, krystal m. in vitro antiviral characteristics of hiv-1 attachment inhibitor bms-626529, the active component of the prodrug bms-663068. antimicrob agents chemother. 2012;56(7):3498-507.
[2] nettles re, schürmann d, zhu l, stonier m, huang sp, chang i, chien c, krystal m, wind-rotolo m, ray n, hanna gj, bertz r, grasela d. pharmacodynamics, safety, and pharmacokinetics of bms-663068, an oral hiv-1 attachment inhibitor in hiv-1-infected subjects. j infect dis. 2012;206(7):1002-11.
[3] MARIANNE BOUTIN. Temsavir Modulates HIV-1 Envelope Conformation by Decreasing Its Proteolytic Cleavage.[J]. Viruses-Basel, 2023. DOI:10.3390/v15051189.

Temsavir Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Temsavir manufacturers

Career Henan Chemical Co

Product: BMS 626529 701213-36-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

701213-36-7, TemsavirRelated Search:

1-Benzoyl-4-[[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]oxoacetyl]piperazine BMS626529

BMS 626529

BMS-626529

1-Benzoyl-4-[[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]oxoacetyl]piperazine

Temsavir

1-(4-benzoylpiperazin-1-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

(1R,2S,3R,6S,7S,10R)-10-ISOPROPYL-3,7-DIMETHYL-11-OXATRICYCLO[5.3.1.0<SUP>2,6</SUP>]UNDECAN-3-OL

1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-

EOS-62215

Temsavir (BMS-626529)

BMS 626529; BMS626529

BMS-626529, Temsavir

CS-1668

1-(4-benzoylpiperazin-1-yl)-2-[4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-1h-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione

Foscarbidopa Impurity 13

701213-36-7

C24H23N7O4