ChemicalBook > CAS DataBase List > Methyl L-histidinate dihydrochloride

Methyl L-histidinate dihydrochloride

Product Name: Methyl L-histidinate dihydrochloride
CAS No.: 7389-87-9
Chemical Name: Methyl L-histidinate dihydrochloride
Synonyms: L-His-OMeHCl;H-His-OMeHCl;L-His-OMe·2HCl;H-HIS-OME 2HCL;H-His-OMe.2HCI;H-L-HIS-OME 2HCL;ester dihydrochL;-Histidine methyL;HISTIDINE-OME 2 HCL;L-Histidine methyl e
CBNumber: CB1264687
Molecular Formula: C7H13Cl2N3O2
Formula Weight: 242.1
MOL File: 7389-87-9.mol

Less

Methyl L-histidinate dihydrochloride Property

Melting point:: 207 °C (dec.)(lit.)
alpha: 9 º (c=2 in H2O)
refractive index: 10 ° (C=2, H2O)
storage temp.: Inert atmosphere,2-8°C
solubility: 100g/l
form: Fine Crystalline Powder
color: White
optical activity: [α]20/D +9.0°, c = 2 in H2O
Water Solubility: Soluble in dimethyl sulfoxide, methanol and water.
Sensitive: Hygroscopic
BRN: 3572010
InChI: InChI=1/C7H11N3O2.2ClH/c1-12-7(11)6(8)2-5-3-9-4-10-5;;/h3-4,6H,2,8H2,1H3,(H,9,10);2*1H/t6-;;/s3
InChIKey: DWAYENIPKPKKMV-ILKKLZGPSA-N
SMILES: C1(N=CNC=1)C[C@H](N)C(=O)OC.Cl.Cl |&1:6,r|
CAS DataBase Reference: 7389-87-9(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29332900

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H15403
Product name: L-Histidine methyl ester dihydrochloride
Purity: 97%
Packaging: 25g
Price: $96.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: H15403
Product name: L-Histidine methyl ester dihydrochloride
Purity: 97%
Packaging: 100g
Price: $267
Updated: 2025/07/31

TCI Chemical

Product number: H0977
Product name: L-Histidine Methyl Ester Dihydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: H0977
Product name: L-Histidine Methyl Ester Dihydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $75
Updated: 2025/07/31

Usbiological

Product number: 013214
Product name: L-Histidine Methyl Ester Dihydrochloride
Packaging: 10g
Price: $319
Updated: 2021/12/16

Less

Methyl L-histidinate dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

L-Histidine methyl ester dihydrochloride is used to prepare optically pure L-(+)-ergothioneine.

Uses

Methyl L-histidinate dihydrochloride is used in the preparation of optically pure L-(+)-Ergothioneine.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

645-35-2

4467-54-3

Example 1; Synthesis of (R)-2-amino-3-(1H-imidazol-4-yl)propanoic acid methyl ester dihydrochloride was carried out by improving the method reported by Cook et al. In a 200 L Schott glass reactor equipped with an air-driven stirrer, a high-efficiency condenser and a gas introduction port, 12.5 kg of L-histidine hydrochloride monohydrate was suspended in 130 L of methanol. Dry HCl gas was passed into the suspension while the mixture was heated to 55-65 °C until complete dissolution. The passage of HCl gas was continued until saturation, at which point it was stopped. Shortly after the solution was formed, a precipitation of the product began to appear. The mixture is stirred continuously and supplemented with additional passes of HCl gas every 1 hour and 15 minutes; the mixture is heated under mild reflux conditions for 8 hours. After the reaction is complete, it can be kept warm for 6-8 hours. Subsequently, 40 L of ethyl acetate is added, stirred for 1 hour and filtered. The filter cake was washed with 10 L of isopropyl ether and the resulting white crystalline product was air dried. The yield was 95%. The melting point was 102-103 °C (literature value 102-103 °C). Spinodal [α]25D = +3.5° (c=2, H2O).1H NMR (D2O) data: δ 3.4 (t, 2H), 3.9 (s, 3H), 4.5 (s, 2H), 7.4 (s, 1H), 8.5 (s, 1H).

References

[1] Tetrahedron Asymmetry, 2008, vol. 19, # 3, p. 273 - 278
[2] Patent: US2009/93642, 2009, A1. Location in patent: Page/Page column 6; 7

Methyl L-histidinate dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Methyl L-histidinate dihydrochloride Suppliers

Americas 1 Belgium 1 Canada 1 China 261 Europe 3 France 1 Germany 6 India 17 Japan 7 Switzerland 8 United Kingdom 14 United States 50 Global 370

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shanghai Jifeng Biotechnology Co., Ltd.

Tel: 021-61263377 15023907684
Fax: 021-61263399
Email: 15800684150@163.com
Country: China
ProdList: 8131
Advantage: 58

Anhui Shuangmai Intelligent Technology Co., LTD

Tel: 19956280676
Email: sales@nbinno.com
Country: China
ProdList: 101
Advantage: 58

shxqsshkj

Tel: 15821483271
Email: 18110220095@fudan.edu.cn
Country: China
ProdList: 10
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Sichuan Tongsheng Amino acids Co.,Ltd.

Tel: 0838-2274206 13908101207
Fax: +86-838-2274207
Email: sales@biots.cn
Country: China
ProdList: 279
Advantage: 66

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9309
Advantage: 66

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4378
Advantage: 65

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Zhangjiagang Specom Biochemical Co., Ltd.

Tel: 512-0512-58992291,58992287 18606280718
Email: admin@spbiochem.com
Country: China
ProdList: 254
Advantage: 62

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Nanjing Dulai Biotechnology Co., Ltd.

Tel: 025-846993838003-8003 18013301590
Fax: 025-84699383-8003
Email: njduly@126.com
Country: China
ProdList: 3249
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Tianjin Chempharmatech Co.,Ltd.

Tel: 022-66211079 13212288319
Fax: qq1405432731
Email: sales@chempharmatech.com
Country: China
ProdList: 918
Advantage: 55

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3921
Advantage: 50

Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
ProdList: 4526
Advantage: 56

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

ShangHai D&B Biological Science and Technology Co.Ltd

Tel: 400-008-9730,021-54359730 400-008-9730
Fax: 021-54353864
Email: info@chemxyz.com
Country: China
ProdList: 3057
Advantage: 60

Zhengzhou HongSheng Pharmaceutical Co., Ltd.

Tel: 0371-0371-13526885213 15637198702
Fax: 0371-63709726
Email: hsyykjchem@163.com
Country: China
ProdList: 3852
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Less

View Lastest Price from Methyl L-histidinate dihydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Methyl L-histidinate dihydrochloride 7389-87-9
Price: US $0.00/Kg/Bag
Min. Order: 100g
Purity: 98.0%min BR
Supply Ability: 10000G
Release date: 2021-08-23

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-L-His-OMe.2Hcl 7389-87-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-23

Henan Aochuang Chemical Co.,Ltd.

Product: Methyl L-histidinate dihydrochloride 7389-87-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-08

7389-87-9, Methyl L-histidinate dihydrochlorideRelated Search:

Methyl salicylate Methyl acrylate Methanol Methyl 2,2-dimethylphenylacetate Kresoxim-methyl p-Phenylenediamine dihydrochloride DL-HISTIDINE MONOHYDROCHLORIDE METSULFURON METHYL Tribenuron methyl 3,3'-Dimethylbenzidine dihydrochloride Ethylenediamine dihydrochloride L-Histidine L-Histidine hydrochloride Methylparaben DIETHANOLAMINE HYDROCHLORIDE Basic Violet 1 Dihydrochloride Methyl

L(+)-HISTIDINE METHYL ESTER DIHYDROCHLORIDE

L-HISTIDINE METHYL ESTER DIHYDROCHLORIDE

L-HISTIDINE METHYL ESTER DIHYDROCHLORIDE SALT

L-HISTIDINE METHYL ESTER HYDROCHLORIDE

(S)-Methyl 2-aMino-3-(1H-iMidazol-4-yl)propanoate dihydrochloride

Methyl (2S)-2-amino-3-(1H-imidazol-4-yl)propanoate dihydrochloride, H-His-OMe.2HCl

L(+)-Histidine Methyl ester dihydrochloride, 97% 25GR

[(1S)-1-(3H-imidazol-1-ium-4-ylmethyl)-2-keto-2-methoxy-ethyl]ammonium dichloride

[(1S)-1-(3H-imidazol-1-ium-4-ylmethyl)-2-methoxy-2-oxoethyl]ammonium dichloride

L-Histidine methyl ester dihydrochloride 97%

(2S)-2-amino-3-(3H-imidazol-4-yl)propanoic acid meth

[(1S)-1-(3H-imidazol-1-ium-4-ylmethyl)-2-methoxy-2-oxo-ethyl]ammonium dichloride

[(2S)-3-(3H-imidazol-1-ium-4-yl)-1-methoxy-1-oxo-propan-2-yl]azanium dichloride

[(2S)-3-(3H-imidazol-1-ium-4-yl)-1-methoxy-1-oxopropan-2-yl]azanium dichloride

methyl (2S)-2-amino-3-(3H-imidazol-4-yl)propanoate dihydrochloride

L-His-OMeHCl

L-His-OMe·2HCl

L-Methyl histidinate dihydrochloride for synthesis

H-HIS-OME 2HCL

HISTIDINE METHYL ESTER DIHYDROCHLORIDE

HISTIDINE-OME 2 HCL

H-L-HIS-OME 2HCL

L-METHYL HISTIDINATE DIHYDROCHLORIDE

H-His-OMe.2HCI

methyl L-histidinate dihydrochloride

L-Histidine Methyl Ester 2HCl

L-HISTIDINE METHYL ESTER DIHCL

ester dihydrochL

2-amino-3-(1H-imidazol-5-yl)propanoic acid methyl ester chloride

L-Histidine methyl ester dihydrochloride, 98+%

Histidine methyl·2hydrochloride

L-Histidine methyl·dihydrochloride

Histidine methyl ester 2HCI

L-Histidine methyl e

H-His-OMeHCl

Methyl (2S)-2-amino-3-(1H-imidazol-4-yl)propanoa

L(+)-Histidine methyl ester dihydrochloride,97%

H-His-OMeHCl / H-His-OMe2HCl

methyl (2S)-2-amino-3-(1H-imidazol-5-yl)propanoate dihydrochloride

L-HistidineMethylEsterDihydrochloride&gt

-Histidine methyL

Methyl L-histidinate dihydrochloride USP/EP/BP

[(2S)-3-(1H-imidazol-3-ium-4-yl)-1-methoxy-1-oxopropan-2-yl]azanium

Methyl-L-histidinatdihydrochlorid

methyl (2S)-2-amino-3-(1H-imidazol-5-yl)propanoate

L-Histidine, methyl ester, hydrochloride (1:2)

Methyl L-histidinate dihydrochloride, 10 mM in DMSO

<sc>L</sc>-Histidine methyl ester dihydrochloride

7389-87-9

Amino Acid Derivatives

Protected & Labeled Amino Acids

Amino Acid Methyl Esters

Amino Acids (C-Protected)

Peptide Synthesis

Specialty Synthesis

Histidine

ESTER

Histidine [His, H]