ChemicalBook > CAS DataBase List > 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID

5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID

Product Name
5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID
CAS No.
10242-10-1
Chemical Name
5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID
Synonyms
RT 63;ASISCHEM D19360;BUTTPARK 40\07-65;5-Chlorocoumarilic acid;ASINEX-REAG BAS 12719327;5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID;5-Chloro-2-benzofurancarboxylic acid;2-Benzofurancarboxylic acid, 5-chloro-;5-Chlorobenzo[b]furan-2-carboxylic acid;5-Chlorobenzofuran-2-carboxylic Acid >
CBNumber
CB1264793
Molecular Formula
C9H5ClO3
Formula Weight
196.59
MOL File
10242-10-1.mol
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5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID Property

Melting point:
275°C (subl.)
Boiling point:
348.8±22.0 °C(Predicted)
Density 
1.502
storage temp. 
2-8°C
form 
powder to crystal
pka
2.94±0.30(Predicted)
color 
White to Light yellow
λmax
301nm(EtOH)(lit.)
CAS DataBase Reference
10242-10-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
29321900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2890
Product name
5-Chlorobenzofuran-2-carboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$85
Updated
2025/07/31
TCI Chemical
Product number
C2890
Product name
5-Chlorobenzofuran-2-carboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$287
Updated
2024/03/01
TRC
Product number
C429068
Product name
5-Chlorobenzofuran-2-carboxylic Acid
Packaging
500mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC75031
Product name
5-Chloro-1-benzofuran-2-carboxylic acid
Packaging
500mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC75031
Product name
5-Chloro-1-benzofuran-2-carboxylic acid
Packaging
1g
Price
$125
Updated
2021/12/16
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5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

Light red powder

Synthesis

685-87-0

635-93-8

10242-10-1

General procedure for the synthesis of 5-chlorobenzofuran-2-carboxylic acid from diethyl bromomalonate and 5-chlorosalicylaldehyde: 5-chlorosalicylaldehyde (10.62 g, 67.8 mmol), diethyl bromomalonate (25.3 g, 105.8 mmol), and anhydrous potassium carbonate (9.37 g, 67.8 mmol) were suspended in ethylmethyl ketone (50 mL), and the reaction was carried out at reflux. The reaction was carried out for 5 h, followed by stirring at room temperature overnight. Upon completion of the reaction, the solvent was removed by evaporation and the residue was diluted with water (500 mL) and neutralized with 1N HCl solution. The resulting suspension was extracted with ether (Et2O) and the organic phase was dried over anhydrous magnesium sulfate (MgSO4) and concentrated. The oily residue was dissolved in anhydrous ethanol (50 mL) and 10% ethanol solution of potassium hydroxide (KOH) was added. The thick suspension formed was refluxed overnight under vigorous stirring. After cooling to room temperature, the solvent was removed by evaporation and water was added. The aqueous phase was washed with ether (Et2O) and the pH was subsequently adjusted to 2 with 1 N HCl. The aqueous suspension was extracted with ethyl acetate (EtOAc), and the organic phase was dried over anhydrous magnesium sulfate (MgSO4) and concentrated to give pure 5-chlorobenzofuran-2-carboxylic acid (7.4 g, 37.6 mmol, 55.5% yield) as a yellow oil.

References

[1] Patent: US6025390, 2000, A
[2] Gazzetta Chimica Italiana, 1955, vol. 85, p. 381,388
[3] Patent: US4332952, 1982, A
[4] Patent: US4342771, 1982, A

5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Potassium tert-butoxide Ethanol Potassium hydroxide 5-Chlorosalicylaldehyde Tetrahydrofuran Ethyl acetate Bromine Diethyl malonate PETROLEUM ETHER

Preparation Products

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5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID Suppliers

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View Lastest Price from 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID 10242-10-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID 10242-10-1
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200KG
Release date
2018-12-23

10242-10-1, 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACIDRelated Search:

5-Chlorobenzofuran Benzofuran-2-carboxylic acid 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID 5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER 3-AMINO-5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER 5-CHLORO-3-METHYL-1-BENZOFURAN-2-CARBOXYLIC ACID CHEMBRDG-BB 6725612 3-AMINO-5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER 5-CHLORO-7-METHOXY-BENZOFURAN-2-CARBOXYLIC ACID 5,7-dichloro-1-benzofuran-2-carboxylic acid BUTTPARK 34\07-71 ETHYL 5-CHLORO-4-NITRO-1-BENZOFURAN-2-CARBOXYLATE BUTTPARK 40\07-66 5,7-dichloro-3-methyl-1-benzofuran-2-carboxylic acid 5-CHLORO-4-NITRO-1-BENZOFURAN-2-CARBOXYLIC ACID BUTTPARK 34\07-72 5-CHLORO-3,6-DIMETHYL-1-BENZOFURAN-2-CARBOXYLIC ACID BUTTPARK 34\07-73

  • ASISCHEM D19360
  • ASINEX-REAG BAS 12719327
  • BUTTPARK 40\07-65
  • 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID
  • 5-Chlorobenzo[b]furan-2-carboxylic acid
  • 5-Chlorobenzofuran-2-carboxylic acid ,97%
  • 5-Chloro-2-benzofurancarboxylic acid
  • 5-Chlorocoumarilic acid
  • RT 63
  • 5-Chloro-1-benzofuran-2-carboxylic acid, 2-Carboxy-5-chlorobenzo[b]furan
  • 5-Chlorobenzofuran-2-carboxylic Acid &gt
  • 2-Benzofurancarboxylic acid, 5-chloro-
  • 5-Chlorobenzofuran-2-Carboxylic Acid Hydrochloride
  • 10242-10-1