1,4-dihydronicotinaMide riboside
- Product Name
- 1,4-dihydronicotinaMide riboside
- CAS No.
- 19132-12-8
- Chemical Name
- 1,4-dihydronicotinaMide riboside
- Synonyms
- Anti-aging;1,4-Dihydronicotimideriboside;Reduced nicotinamide riboside;1,4-dihydronicotinaMide riboside;Reduced nicotinamide riboside(NRH);1-(β-D-Ribofuranosyl)-1,4-dihydronicotinamide;1,4-Dihydro-1-β-D-ribofuranosyl-3-pyridinecarboxamide;D-Ribofuranosyldihydronicotinamide, mixture of isomers;3-Pyridinecarboxamide, 1,4-dihydro-1-β-D-ribofuranosyl-;1-(D-Ribo furanosyl)-1,4-dihydro-3-pyridine carboxamide
- CBNumber
- CB12648605
- Molecular Formula
- C11H16N2O5
- Formula Weight
- 256.26
- MOL File
- 19132-12-8.mol
1,4-dihydronicotinaMide riboside Property
- Boiling point:
- 598.3±50.0 °C(Predicted)
- Density
- 1.539±0.06 g/cm3(Predicted)
- pka
- 13.37±0.70(Predicted)
- InChI
- InChI=1/C6H8N2O.C5H10O5/c7-6(9)5-2-1-3-8-4-5;6-2-1-10-5(9)4(8)3(2)7/h1,3-4,8H,2H2,(H2,7,9);2-9H,1H2/t;2-,3-,4-,5?/s3
- InChIKey
- HMERANLWHIIDCI-UCPMJXAVNA-N
- SMILES
- C(N)(=O)C1=CNC=CC1.OC1OC[C@@H](O)[C@@H](O)[C@H]1O |&1:13,15,17,r|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- MR31174
- Product name
- Reduced nicotinamide riboside
- Packaging
- 10mg
- Price
- $2500
- Updated
- 2021/12/16
- Product number
- MR31174
- Product name
- Reduced nicotinamide riboside
- Packaging
- 25mg
- Price
- $4000
- Updated
- 2021/12/16
1,4-dihydronicotinaMide riboside Chemical Properties,Usage,Production
Uses
Reduced Nicotinamide Riboside is a precursor which is an essential cofactor and substrate for many cells.
Definition
ChEBI: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide is a pyridine nucleoside consisting of 1,4-dihydronicotinamide with a beta-D-ribofuranosyl moiety at the 1-position. It is a dihydropyridine and a pyridine nucleoside.
Preparation
There are very few methods for preparing 1,4-dihydronicotinaMide riboside (NRH). This compound can be prepared from dihydronicotinamide mononucleotide (NMNH) by hydrolysis of the 5′-phosphate ester in alkaline phosphatase. This method is time-consuming and is not cost-effective because NMNH as a precursor must be enzymatically hydrolyzed from NADH. Another method for synthesising NRH is reducing NR in the presence of sodium dithionate (Na2S2O4) as a reducing agent. In this method, nicotinamide riboside triflate is reduced to NRH in an aqueous solution of sodium dithionate and potassium hydrogen phosphate. Because the aqueous solution of Na2S2O4 is very unstable at ambient conditions, this reaction must be carried out at low temperatures and under anaerobic, alkaline conditions[1].
Biological Activity
1,4-dihydronicotinamide riboside (NRH) is a potent NAD+ concentration enhancer both in vitro and in vivo. Researchers found that, after administration of NRH to mammalian cells, the NAD+ concentration increased by 2.5–10fold over control values in just one hour. Their findings demonstrate that the use of NRH is more effective than either NR or NMN. Moreover, NRH considerably enhances the NAD+/NADH ratio in the cultured cells without induction of apoptotic markers or a substantial increase in cell lactate levels. More recently, Canto et al. have found that contrary to the NR pathway, NRH uses different steps and enzymes to synthesize NAD+. That explains why NRH is a more effective and faster NAD+ precursor than NR in mammalian cells. In experiments with mice, the same researchers have also demonstrated that NRH is orally bioavailable as an NAD+ precursor and prevents cisplatin-induced acute kidney injury. In addition to increasing NAD+ levels, NRH can also deplete some genotoxins, such as hydrogen peroxide and methylmethane sulfonate. As a result, the mouse cells treated with NRH are resistant to cell death[1].
References
[1] Zarei, Amin et al. “Dihydronicotinamide riboside: synthesis from nicotinamide riboside chloride, purification and stability studies?.” RSC Advances 34 (2021): 21036–21047.
1,4-dihydronicotinaMide riboside Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,4-dihydronicotinaMide riboside manufacturers
- Product
- 1,4-dihydronicotinaMide riboside 19132-12-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 1000 kg
- Release date
- 2024-03-29