AMidepsine D

Product Name: AMidepsine D
CAS No.: 79786-34-8
Chemical Name: AMidepsine D
Synonyms: Amidepsin D;AMidepsine D;2,4-di-O-methylgyrophoric acid;4-[(2,4-Dimethoxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methyl-benzoic acid 4-carboxy-3-hydroxy-5-methylphenyl ester;Benzoic acid, 4-[(2,4-dimethoxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methyl-, 4-carboxy-3-hydroxy-5-methylphenyl ester
CBNumber: CB12650495
Molecular Formula: C26H24O10
Formula Weight: 496.46
MOL File: 79786-34-8.mol

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AMidepsine D Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
color: White to light pink

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17775
Product name: Amidepsine D
Purity: ≥95%
Packaging: 1mg
Price: $275
Updated: 2024/03/01

Cayman Chemical

Product number: 17775
Product name: Amidepsine D
Purity: ≥95%
Packaging: 2.5mg
Price: $547
Updated: 2024/03/01

TRC

Product number: A576700
Product name: AmidepsineD
Packaging: 10mg
Price: $1230
Updated: 2021/12/16

Usbiological

Product number: 207044
Product name: Amidepsine D
Packaging: 1mg
Price: $443
Updated: 2021/12/16

Adipogen Life Sciences

Product number: AG-CN2-0110-MM25
Product name: AmidepsineD
Purity: ≥95%(HPLC)
Packaging: 2.5mg
Price: $470
Updated: 2021/12/16

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AMidepsine D Chemical Properties,Usage,Production

Uses

Amidepsine D is a fungal metabolite isolated from the culture broth of Humicola sp, which inhibits DGAT activity, thus triacylglycerol formation is attenuated and protects against the development of diet-induced obesity or insulin-resistance.

Biological Activity

amidepsine d is a fungal metabolite isolated from the culture broth of humicola sp fo-2942. amidepsine a is an inhibitor of dylglycerol acyltransferase (dgat).dylglycerol acyltransferase (dgat) has been involved in catalyzing the formation of triglycerides from diacylglycerol and acyl-coa. the reaction is considered the terminal and only committed step in triglyceride synthesis and is essential for the formation of adipose tissue. there are two isozymes of dgat have been identified: dgat1 and dgat2. dgat-1 deficient mice are lean and resistant to the development of diet-induced obesity or insulin resistance [1]. dgat2-/- mice demonstrate reduced triglyceride levels and suffer from skin barrier abnormalities [2].fo-2942 inhibited dgat activity with an ic50 of 10.2 μm in rat liver microsomes. fo-2942 inhibited triacylglycerol formation in raji cells with the ic50 value of 15.5 μm [1].

storage

+4°C

References

[1] tomoda h, tabata n, ito m, et al. amidepsines, inhibitors of diacylglycerol acyltransferase produced by humicola sp. fo-2942[j]. the journal of antibiotics, 1995, 48(9): 942-947.
[2] smith s j, cases s, jensen d r, et al. obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking dgat[j]. nature genetics, 2000, 25(1): 87-90.
[3] stone s j, myers h m, watkins s m, et al. lipopenia and skin barrier abnormalities in dgat2-deficient mice[j]. journal of biological chemistry, 2004, 279(12): 11767-11776.

AMidepsine D Preparation Products And Raw materials

Raw materials

Preparation Products

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AMidepsine D Suppliers

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79786-34-8, AMidepsine DRelated Search:

AMidepsine D

4-[(2,4-Dimethoxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methyl-benzoic acid 4-carboxy-3-hydroxy-5-methylphenyl ester

2,4-di-O-methylgyrophoric acid

Benzoic acid, 4-[(2,4-dimethoxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methyl-, 4-carboxy-3-hydroxy-5-methylphenyl ester

Amidepsin D

79786-34-8

C26H24O10