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Tropodithietic acid [TDA]

Product Name
Tropodithietic acid [TDA]
CAS No.
750590-18-2
Chemical Name
Tropodithietic acid [TDA]
Synonyms
Tropodithietic acid;Tropodithietic acid [TDA];from Phaeobacter inhibens;3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid;8,9-Dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid, 3-oxo-
CBNumber
CB12650819
Molecular Formula
C8H4O3S2
Formula Weight
212.24556
MOL File
750590-18-2.mol
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Tropodithietic acid [TDA] Property

storage temp. 
-20°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
form 
powder
color 
faint yellow to dark yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
2941900000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0735
Product name
Tropodithietic acid
Purity
≥98% (HPLC)
Packaging
5mg
Price
$861
Updated
2022/05/15
Cayman Chemical
Product number
23244
Product name
Tropodithietic Acid
Purity
≥98%
Packaging
1mg
Price
$171
Updated
2024/03/01
Usbiological
Product number
207429
Product name
Tropodithietic acid
Packaging
1mg
Price
$359
Updated
2021/12/16
TRC
Product number
T892703
Product name
Tropodithietic acid
Packaging
2.5mg
Price
$475
Updated
2021/12/16
Adipogen Life Sciences
Product number
BVT-0152-M001
Product name
Tropodithietic acid
Purity
≥98%(HPLC)
Packaging
1mg
Price
$90
Updated
2021/12/16
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Tropodithietic acid [TDA] Chemical Properties,Usage,Production

Description

Tropodithietic acid (750590-18-2) displays potent broad-spectrum anticancer activity.1 Displays cytotoxic effects on mammalian cell lines (neuronal N2a cells and OLN-93 cells as model systems for nerve cells and glia) acting via disruption of mitochondrial membrane potential, activation of ERK1/2 and induction of HSP32/HO-1 (considered as a sensor of oxidative stress).2 A broad-spectrum antibiotic agent produced by marine bacteria which does not appear to induce resistance after long-term exposure.3

Uses

Tropodithietic Acid (cas# 750590-18-2) is a compound useful in organic synthesis.

Definition

ChEBI: Tropodithietic acid is a monocarboxylic acid that is 8,9-dithiabicyclo[5.2.0]nona-1,3,6-triene substituted by a carboxy group at position 2 and an oxo group at position 3. It is a broad spectrum antibiotic produced by the marine bacterium Phaeobacter inhibens that also acts as a signalling molecule at lower concentrations. It has a role as a toxin, a signalling molecule, a marine metabolite, an antibacterial agent and a bacterial metabolite. It is an organic disulfide, a cyclic ketone, an organosulfur heterocyclic compound, an organic heterobicyclic compound and a monocarboxylic acid. It is a tautomer of a thiotropocin.

storage

+4°C

References

1) Wilson et al. (2016), Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink; Proc. Natl. Acad. Sci. USA, 113 1630 2) Wichmann et al. (2015), Cytotoxic Effects of Tropodithietic Acid on Mammalian Clonal Cell Lines of Neuronal and Glial Origin; Mar. Drugs, 13 7113 3) Rasmussen et al. (2016), Vibro anguillarum is Genetically and Phenotypically Unaffected by Long-Term Continuous Exposure to the Antibacterial Compound Tropodithietic Acid; Appl. Environ. Microbiol., 82 4802

Tropodithietic acid [TDA] Preparation Products And Raw materials

Raw materials

Preparation Products

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Tropodithietic acid [TDA] Suppliers

750590-18-2, Tropodithietic acid [TDA]Related Search:


  • Tropodithietic acid [TDA]
  • 3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid
  • Tropodithietic acid
  • 8,9-Dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid, 3-oxo-
  • from Phaeobacter inhibens
  • 750590-18-2
  • C8H4O3S2