6-BroMochroMan-2-one
- Product Name
- 6-BroMochroMan-2-one
- CAS No.
- 20921-00-0
- Chemical Name
- 6-BroMochroMan-2-one
- Synonyms
- 6-BroMochroMan-2-one;6-bromo-2-chromanone;6-bromo-3,4-dihydrochromen-2-one;2H-1-Benzopyran-2-one, 6-bromo-3,4-dihydro-
- CBNumber
- CB12651917
- Molecular Formula
- C9H7BrO2
- Formula Weight
- 227.05
- MOL File
- 20921-00-0.mol
6-BroMochroMan-2-one Property
- Melting point:
- 98 °C
- Boiling point:
- 329.5±31.0 °C(Predicted)
- Density
- 1.621±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- 0692AB
- Product name
- 6-Bromochroman-2-one
- Packaging
- 5g
- Price
- $354
- Updated
- 2021/12/16
- Product number
- HCH0367823
- Product name
- 6-BROMOCHROMAN-2-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.44
- Updated
- 2021/12/16
- Product number
- CM162479
- Product name
- 6-bromochroman-2-one
- Purity
- 95%
- Packaging
- 25g
- Price
- $645
- Updated
- 2021/12/16
- Product number
- CD11167326
- Product name
- 6-Bromochroman-2-one
- Purity
- 95+%
- Packaging
- 25g
- Price
- $683
- Updated
- 2021/12/16
- Product number
- 20921000
- Product name
- 6-Bromochroman-2-one
- Packaging
- 25g
- Price
- $690
- Updated
- 2021/12/16
6-BroMochroMan-2-one Chemical Properties,Usage,Production
Synthesis
119-84-6
20921-00-0
The general procedure for the synthesis of 6-bromochroman-2-one from hydrogenated cinnamic acid lactone is as follows: a solution of bromine (155 mL) in dichloromethane (500 mL) was slowly added dropwise to a solution of 3,4-dihydrocoumarin (450 g, 0.3 mol) in dichloromethane (2000 mL) over a period of 30 minutes. The reaction mixture was stirred overnight at 15 °C. After completion of the reaction, the reaction solution was diluted with dichloromethane (2000 mL) and washed sequentially with aqueous sodium bicarbonate (2 x 1000 mL) and water (1000 mL). The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was washed with petroleum ether (2 x 500 mL), the filtrates were combined and concentrated. Finally, the target compound 6-bromochroman-2-one (BM1490) was obtained as white thick crystals (471 g, 74% yield) by recrystallization from a solvent mixture of dichloromethane/petroleum ether.
References
[1] Journal of Organometallic Chemistry, 1990, vol. 387, # 3, p. 381 - 390
[2] Patent: WO2017/49343, 2017, A1. Location in patent: Paragraph 0066
[3] Patent: EP3135667, 2017, A1. Location in patent: Paragraph 0425-0426
[4] Justus Liebigs Annalen der Chemie, 1884, vol. 226, p. 359
[5] Journal of Organic Chemistry, 1997, vol. 62, # 24, p. 8522 - 8528
6-BroMochroMan-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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