2-BroMo-4-chloro-6-fluorobenzaldehyde

Product Name: 2-BroMo-4-chloro-6-fluorobenzaldehyde
CAS No.: 1135531-73-5
Chemical Name: 2-BroMo-4-chloro-6-fluorobenzaldehyde
Synonyms: 2-BroMo-4-chloro-6-fluorobenzaldehyde;Benzaldehyde, 2-bromo-4-chloro-6-fluoro-;2-Bromo-4-chloro-6-fluorobenzaldehyde - [B44232]
CBNumber: CB12651957
Molecular Formula: C7H3BrClFO
Formula Weight: 237.45
MOL File: 1135531-73-5.mol

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2-BroMo-4-chloro-6-fluorobenzaldehyde Property

Boiling point:: 256.1±35.0 °C(Predicted)
Density: 1.779±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: crystalline powder
color: Light yellow
InChI: InChI=1S/C7H3BrClFO/c8-6-1-4(9)2-7(10)5(6)3-11/h1-3H
InChIKey: MHISGFZIXPJJRW-UHFFFAOYSA-N
SMILES: C(=O)C1=C(F)C=C(Cl)C=C1Br

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Safety

HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B874568
Product name: 2-Bromo-4-chloro-6-fluorobenzaldehyde
Packaging: 500mg
Price: $165
Updated: 2021/12/16

Apolloscientific

Product number: PC56942
Product name: 2-Bromo-4-chloro-6-fluorobenzaldehyde
Packaging: 250mg
Price: $38
Updated: 2021/12/16

Apolloscientific

Product number: PC56942
Product name: 2-Bromo-4-chloro-6-fluorobenzaldehyde
Packaging: 1g
Price: $94
Updated: 2021/12/16

Apolloscientific

Product number: PC56942
Product name: 2-Bromo-4-chloro-6-fluorobenzaldehyde
Packaging: 5g
Price: $345
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0363174
Product name: 2-BROMO-4-CHLORO-6-FLUOROBENZALDEHYDE
Purity: 95.00%
Packaging: 5MG
Price: $503.98
Updated: 2021/12/16

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2-BroMo-4-chloro-6-fluorobenzaldehyde Chemical Properties,Usage,Production

Synthesis

208186-78-1

68-12-2

1135531-73-5

Step 1: Isopropylmagnesium chloride (19.2 mL, 1 M in tetrahydrofuran) was slowly added to a mixture of 1,2-dibromo-5-chloro-3-fluorobenzene (5 g, 17.5 mmol) in hexane (12 mL) and tetrahydrofuran (20 mL) at -45 °C. The reaction temperature was maintained at -40°C. Subsequently, N,N-dimethylformamide (6.4 g, 87.5 mmol) was slowly added dropwise to the above reaction mixture and stirred at the same temperature for 30 min. After completion of the reaction, the reaction was quenched with hydrochloric acid (15 mL, 2.0 M). The mixture was gradually warmed to room temperature and diluted with ethyl acetate (80 mL) to separate the organic phase. The organic phase was washed with saturated brine, filtered and the filtrate concentrated under reduced pressure. The residue was purified by fast column chromatography (petroleum ether/ethyl acetate = 10/1) to afford 2-bromo-4-chloro-6-fluorobenzaldehyde (3 g, yield: 73%) as a yellow solid.

References

[1] Patent: US2012/165338, 2012, A1. Location in patent: Page/Page column 20
[2] Patent: WO2012/89601, 2012, A1. Location in patent: Page/Page column 49-50
[3] Patent: US2013/18055, 2013, A1. Location in patent: Paragraph 0379-0380
[4] Patent: CN107556244, 2018, A. Location in patent: Paragraph 0221-0223

2-BroMo-4-chloro-6-fluorobenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BroMo-4-chloro-6-fluorobenzaldehyde Suppliers

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1135531-73-5, 2-BroMo-4-chloro-6-fluorobenzaldehydeRelated Search:

2-BroMo-4-chloro-6-fluorobenzaldehyde

Benzaldehyde, 2-bromo-4-chloro-6-fluoro-

2-Bromo-4-chloro-6-fluorobenzaldehyde - [B44232]

1135531-73-5