ChemicalBook > CAS DataBase List > 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile

4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile

Product Name
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
CAS No.
1197377-47-1
Chemical Name
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
Synonyms
(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile;4-(3-AMINO-1,2,4-TRIAZIN-6-YL)-2-FLUOROBENZONITRILE;Benzonitrile, 4-(3-amino-1,2,4-triazin-6-yl)-2-fluoro-
CBNumber
CB12652323
Molecular Formula
C10H6FN5
Formula Weight
215.19
MOL File
1197377-47-1.mol
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4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile Property

Boiling point:
497.4±55.0 °C(Predicted)
Density 
1.46±0.1 g/cm3 (20 ºC 760 Torr)
pka
2?+-.0.63(Predicted)
InChI
InChI=1S/C10H6FN5/c11-8-3-6(1-2-7(8)4-12)9-5-14-10(13)16-15-9/h1-3,5H,(H2,13,14,16)
InChIKey
JXQHTMHBDHVPDQ-UHFFFAOYSA-N
SMILES
C(#N)C1=CC=C(C2N=NC(N)=NC=2)C=C1F
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0101071
Product name
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
Purity
97.05%
Packaging
100mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-0101071
Product name
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
Purity
97.05%
Packaging
250mg
Price
$120
Updated
2021/12/16
AK Scientific
Product number
2209AQ
Product name
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
Packaging
250mg
Price
$244.4
Updated
2021/12/16
ChemScene
Product number
CS-0101071
Product name
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
Purity
97.05%
Packaging
1g
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0101071
Product name
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
Purity
97.05%
Packaging
5g
Price
$750
Updated
2021/12/16
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4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile Chemical Properties,Usage,Production

Uses

4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile is a useful research chemical compound used in the preparation of salts of [(quinolinylmethyl)imidazotriazinyl]benzamide as tyrosine kinase inhibitors useful in the treatment of diseases.

Synthesis

4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile could be synthesize from the reaction of 6-bromo-1,2,4-triazin-3-amine with 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile. A solution concluding these two compounds in 1,4-dioxane (1200 mL) was stirred before K2CO3 was added. The reaction mixture was degassed by bubbling with nitrogen before 1,1'-bis(diphenyl phosphine)ferrocene dichloropalladium(II) complex with dichloromethane (1:1) (Pd(dppf)2Cl2 was added. The resulting reaction mixture was degassed by bubbling with nitrogen and then heated at 86° C. After the reaction mixture was cooled to 0-5° C. 1,4-Dioxane was added before aqueous hydrochloric acid solution was added dropwise to adjust pH to 0.40-0.93. The mixture was stirred at for 30 min and filtered. The solid collected was stirred with 1,4-dioxane, and HCl added. Finally, after purification, product 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile was obtained.

Solubility in organics

Very soluble in N,N-Dimethylformamide,Soluble in methanol,Sparingly soluble inglacial acetic acid, Very slightly soluble inchloroform, Practically insoluble in water.

storage

Keep in dark place,Inert atmosphere,Room temperature

4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile Suppliers

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View Lastest Price from 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile manufacturers

Zison Pharmaceutical (Shandong) Co., Ltd.
Product
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile 1197377-47-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥98% by HPLC
Supply Ability
100kg/month
Release date
2023-07-22
Nanjing Fred Technology Co., Ltd
Product
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile 1197377-47-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-21
Henan Fengda Chemical Co., Ltd
Product
4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile 1197377-47-1
Price
US $101.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-28

1197377-47-1, 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrileRelated Search:

2-Aminobenzotrifluoride

  • 4-(3-AMINO-1,2,4-TRIAZIN-6-YL)-2-FLUOROBENZONITRILE
  • Benzonitrile, 4-(3-amino-1,2,4-triazin-6-yl)-2-fluoro-
  • (3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile
  • 1197377-47-1
  • C10H6FN5