AdelMitrol
- Product Name
- AdelMitrol
- CAS No.
- 1675-66-7
- Chemical Name
- AdelMitrol
- Synonyms
- Demiqu;NSC 27132;AdelMitrol;AdelMitrol USP/EP/BP;N,N'-Bis(2-hydroxyethyl)nonanediamide;N1,N9-bis(2-hydroxyethyl)-nonanediamide;Nonanediamide, N1,N9-bis(2-hydroxyethyl)-;China biggest manufacturer,AdelMitrol,1675-66-7;NF-κB,Nuclear factor-kappaB,PPAR,COX,Adelmidrol,Cyclooxygenase,Peroxisome proliferator-activated receptors,inhibit,Inhibitor,Nuclear factor-κB
- CBNumber
- CB12657232
- Molecular Formula
- C13H26N2O4
- Formula Weight
- 274.36
- MOL File
- 1675-66-7.mol
AdelMitrol Property
- Melting point:
- 132-134℃
- Boiling point:
- 596.4±45.0 °C(Predicted)
- Density
- 1.097±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:77.5(Max Conc. mg/mL);282.47(Max Conc. mM)
Ethanol:28.0(Max Conc. mg/mL);102.06(Max Conc. mM)
Water:55.0(Max Conc. mg/mL);200.47(Max Conc. mM) - pka
- 14.19±0.10(Predicted)
- InChI
- InChI=1S/C13H26N2O4/c16-10-8-14-12(18)6-4-2-1-3-5-7-13(19)15-9-11-17/h16-17H,1-11H2,(H,14,18)(H,15,19)
- InChIKey
- PAHZPHDAJQIETD-UHFFFAOYSA-N
- SMILES
- C(NCCO)(=O)CCCCCCCC(NCCO)=O
N-Bromosuccinimide Price
- Product number
- A247540
- Product name
- Adelmidrol
- Packaging
- 25mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-4543
- Product name
- Adelmidrol
- Purity
- ≥98.0%
- Packaging
- 100mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- 1760CB
- Product name
- Adelmidrol
- Packaging
- 1g
- Price
- $848
- Updated
- 2021/12/16
- Product number
- DC10745
- Product name
- Adelmidrol
- Purity
- >98%
- Packaging
- 1g
- Price
- $800
- Updated
- 2021/12/16
- Product number
- A103800
- Product name
- Adelmidrol
- Purity
- 98+%
- Packaging
- 25mg
- Price
- $24
- Updated
- 2021/12/16
AdelMitrol Chemical Properties,Usage,Production
Description
N,N'-Bis(2-hydroxyethyl)nonanediamide, also named Admidol, is an anti-inflammatory ethanolamide derivative. It is hydrophilic and hydrophobic, favoring its solubility in water and organic media. As an naturally occurring saturated dicarboxylic acid, it is found in trace amounts in the human body and in some whole grains. Adelmidrol is an analogue of palmitoylethanolamide (PEA), which is a well-known anti-inflammatory and anti-oxidant compound. Adelmidrol was able to manage the significant incapacity of antioxidants and elevation of the oxidant burden[1-2].
Uses
Adelmidrol is an anti-inflammatory. It can be used in biological study of protective effect of adelmidrol as new palmitoylethanolamide analog for pharmacol. treatment of inflammatory bowel disease in mouse model.
Biological Activity
Adelmidrol is an analog of hexadecylamide ethanol (PEA) with anti-inflammatory activity.
in vitro
Adelmidrol is a palmitoylethanolamide analogue. Adelmidrol reduces NF-κB translocation, COX-2, and p-ERK expression; proinflammatory cytokine release; and the incidence of nitrotyrosine and poly(ADP)ribose in the colon.
p>
target
| NF-κB < span> | COX-2
| PPARγ
|
References
[1] Cordaro M, et al. Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease. BIOCHEMICAL PHARMACOLOGY, 2016; 90: 549-561
[2] Fusco R, et al. Adelmidrol: A New Promising Antioxidant and Anti-Inflammatory Therapeutic Tool in Pulmonary Fibrosis. Antioxidants, 2020; 9.
[3] Guida F, et al. Targeting Neuroinflammation in Osteoarthritis with Intra-Articular Adelmidrol. 2022; 12.
AdelMitrol Preparation Products And Raw materials
Raw materials
Preparation Products
AdelMitrol Suppliers
View Lastest Price from AdelMitrol manufacturers
- Product
- AdelMitrol 1675-66-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-16
- Product
- AdelMitrol 1675-66-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-25
- Product
- Adelmitrol 1675-66-7
- Price
- US $0.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-01-31