CX6258

ChemicalBook > CAS DataBase List > CX6258

Product Name: CX6258
CAS No.: 1202916-90-2
Chemical Name: CX6258
Synonyms: CX6258;CS-1091;CX-6258/CX6258;CX-6258, >=98%;CX-6258;CX6258;CX 6258;(E)-5-Chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2;(Z)-5-CHLORO-3-((5-(3-(4-METHYL-1,4-DIAZEPANE-1-CARBONYL)PHENYL)FURAN-2-YL)METHYLENE)INDOLIN-2-ONE.HCL;(3E)-5-Chloro-3-[(5-{3-[(4-methyl-1,4-diazepan-1-yl)carbonyl]phen yl}-2-furyl)methylene]-1,3-dihydro-2H-indol-2-one;(3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one;2H-indol-2-one 5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1h-14-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro- (3e)-
CBNumber: CB12659584
Molecular Formula: C26H24ClN3O3
Formula Weight: 461.94
MOL File: 1202916-90-2.mol

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CX6258 Property

Boiling point:: 697.8±55.0 °C(Predicted)
Density: 1.309±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in EtOH; ≥11.15 mg/mL in DMSO; ≥2.575 mg/mL in H2O with gentle warming
form: solid
pka: 11.38±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16245
Product name: CX-6258
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 16245
Product name: CX-6258
Purity: ≥98%
Packaging: 5mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 16245
Product name: CX-6258
Purity: ≥98%
Packaging: 10mg
Price: $168
Updated: 2024/03/01

Cayman Chemical

Product number: 16245
Product name: CX-6258
Purity: ≥98%
Packaging: 25mg
Price: $356
Updated: 2024/03/01

TRC

Product number: C858803
Product name: CX-6258
Packaging: 100mg
Price: $495
Updated: 2021/12/16

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CX6258 Chemical Properties,Usage,Production

Uses

CX-6258 is a potent, selective, and orally efficacious pan-Pim kinases inhibitor.

Biological Activity

pim kinases (provirus integration site for moloney murine leukemia virus) are a family of serine/threonine kinases that regulate cell survival. this family of kinases is composed of three different isoforms (pim-1, pim-2, and pim-3). the simultaneous inhibition of pim-1, pim-2, and pim-3 kinases is emerging as a promising strategy for anticancer drug development. cx-6258 is a potent, selective, and orally efficacious pan-pim kinases inhibitor.

in vitro

cx-6258 exhibited in vitro synergy with chemotherapeutics. the antiproliferative activity of cx-6258 was examined against a panel of cell lines derived from human solid tumors and hematological malignancies. cx-6258 demonstrated robust antiproliferative potencies against all cell lines tested [1].

in vivo

cx-6258 was evaluated in two human tumor xenograft growth efficacy models, acute myeloid leukemia mv-4-11, and prostate adenocarcinoma pc3. the drug exhibited dose dependent efficacy, with a 50 mg/kg dose producing 45% tumor growth inhibition (tgi) and a 100 mg/kg dose producing 75% tgi. in addition, cx-6258 displayed significant efficacy in vivo in two xenograft models representing the diseases where pim kinases had been shown to play an important role [1].

target

Pim1

References

[1] haddach m, michaux j, schwaebe mk, et al. discovery of cx-6258. a potent, selective, and orally efficacious pan-pim kinases inhibitor. acs med chem lett. 2011;3(2):135-9.

CX6258 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CX6258 manufacturers

Career Henan Chemical Co

Product: CX6258 1202916-90-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-02

1202916-90-2, CX6258Related Search:

(3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one CX-6258

CX6258 (3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one

CX6258

CX-6258/CX6258

(Z)-5-CHLORO-3-((5-(3-(4-METHYL-1,4-DIAZEPANE-1-CARBONYL)PHENYL)FURAN-2-YL)METHYLENE)INDOLIN-2-ONE.HCL

(3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one

CX-6258, >=98%

CX-6258;CX6258;CX 6258

(E)-5-Chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2

2H-indol-2-one 5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1h-14-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro- (3e)-

(3E)-5-Chloro-3-[(5-{3-[(4-methyl-1,4-diazepan-1-yl)carbonyl]phen yl}-2-furyl)methylene]-1,3-dihydro-2H-indol-2-one

CS-1091

1202916-90-2

Inhibitors

JAK

STAT

JAK/STAT