ChemicalBook > CAS DataBase List > Methyl 6-chloro-5-(trifluoroMethyl)picolinate
Methyl 6-chloro-5-(trifluoroMethyl)picolinate
- Product Name
- Methyl 6-chloro-5-(trifluoroMethyl)picolinate
- CAS No.
- 1211518-35-2
- Chemical Name
- Methyl 6-chloro-5-(trifluoroMethyl)picolinate
- Synonyms
- Methyl 6-chloro-5-(trifluoroMethyl)picolinate;Methyl 6-chloro-5-(trifluoromethyl)pyridine-2-carboxylate;6-Chloro-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 6-chloro-5-(trifluoromethyl)-, methyl ester
- CBNumber
- CB12661167
- Molecular Formula
- C8H5ClF3NO2
- Formula Weight
- 239.58
- MOL File
- 1211518-35-2.mol
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Methyl 6-chloro-5-(trifluoroMethyl)picolinate Property
- Boiling point:
- 299.8±40.0 °C(Predicted)
- Density
- 1.443±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.45±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0041631
- Product name
- Methyl6-chloro-5-(trifluoromethyl)picolinate
- Purity
- 98.69%
- Packaging
- 1g
- Price
- $183
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0369605
- Product name
- METHYL-6-CHLORO-5-(TRIFLUOROMETHYL)PICOLINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.61
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0041631
- Product name
- Methyl6-chloro-5-(trifluoromethyl)picolinate
- Purity
- 98.69%
- Packaging
- 5g
- Price
- $638
- Updated
- 2021/12/16
AK Scientific
- Product number
- Z3982
- Product name
- Methyl6-chloro-5-(trifluoromethyl)picolinate
- Packaging
- 5g
- Price
- $919
- Updated
- 2021/12/16
AK Scientific
- Product number
- Z3982
- Product name
- Methyl6-chloro-5-(trifluoromethyl)picolinate
- Packaging
- 100mg
- Price
- $99
- Updated
- 2021/12/16
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Methyl 6-chloro-5-(trifluoroMethyl)picolinate Chemical Properties,Usage,Production
Uses
Methyl 6-Chloro-5-(trifluoromethyl)picolinate is used in preparation of pyridine amides as cannabinoid CB2 receptor agonists.
Synthesis
1415899-18-1
1211518-35-2
Methyl oxo-5-trifluoromethylpyridine-2-carboxylate (2.2 g, 10 mmol) was added batchwise to phosphoric acid trichloride (CAS 10025-87-3, 10 mL) at 0 °C, the reaction mixture was stirred and reacted at 50 °C overnight. Upon completion of the reaction, the solvent was removed by vacuum distillation to give a brown oil. The oily substance was dissolved in ethyl acetate (30 mL) and minimally neutralized with aqueous sodium carbonate. The neutralized mixture was extracted with ethyl acetate (2 x 30 mL), the organic phases were combined and washed with brine (30 mL), dried over anhydrous sodium sulfate, filtered and concentrated to give a light brown solid. Purification of the above solid by column chromatography (silica gel, 15 g, 3% petroleum ether solution of ethyl acetate) resulted in methyl 6-chloro-5-(trifluoromethyl)pyridinecarboxylate (1.5 g, 63% yield) as a white solid; mass spectrum (EI): m/e = 240.0 [M + H]+.
References
[1] Patent: US2012/316147, 2012, A1. Location in patent: Page/Page column 77
[2] Patent: WO2012/168350, 2012, A1. Location in patent: Page/Page column 159; 160
[3] Patent: WO2014/86705, 2014, A1. Location in patent: Page/Page column 62
Methyl 6-chloro-5-(trifluoroMethyl)picolinate Preparation Products And Raw materials
Raw materials
Preparation Products
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