Chloromethyl methyl ether Property

Melting point:

-103.5°C

Boiling point:

bp 59°

Density 

d420 1.0605

vapor pressure 

260 mmHg at 20 °C

refractive index 

nD20 1.39737

Flash point:

15℃ (tag closed test)

storage temp. 

2-8°C

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Colorless liquid

color 

Colourless to Light Yellow

Odor

Similar to HCl

Exposure limits

TLV-TWA — none assigned, A2-Suspected Human Carcinogen (ACGIH 1988); Carcinogen–Human Limited Evidence (IARC); Carcinogen (OSHA).

LogP

0.320

IARC

1 (Vol. 4, Sup 7, 100F) 2012

EPA Substance Registry System

Chloromethyl methyl ether (107-30-2)

Safety

Hazardous Substances Data

107-30-2(Hazardous Substances Data)

Toxicity

LC50 inhal (rat) 55 ppm (180 mg/m3; 7 h)
LD50 oral (rat) 817 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H330Fatal if inhaled

H350May cause cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

Chloromethyl methyl ether Chemical Properties,Usage,Production

Description

Chloromethyl methyl ether is a volatile, highlyflammable, corrosive liquid with an ether-like odor.Molecular weight =80.50; Specific gravity (H2O:1) =1.06;Boiling point =58.8℃; Freezing/Melting point=-103.3℃; Vapor pressure =192 mmHg at 20℃; Flashpoint 5=-17.8℃.[icsc] Hazard Identification (based onNFPA 704 M Rating System): Health 3, Flammability 3,Reactivity 2. Decomposes in water. Commercial chloromethyl methyl ether contains from 1 to 7% bis(chloromethyl)ether, a known cause of lung cancer in humans.

Chemical Properties

Colorless liquid.Decomposes in water; soluble in alcohol and ether.

Chemical Properties

Chloromethyl methyl ether is a volatile, highly flammable, corrosive liquid with an ethereal odor.

Uses

Chloromethyl methyl ether (CMME) is usedas a methylating agent in the synthesis ofchloromethylated compounds.

Uses

Chemical intermediate; preparation of ion-exchange resins

Uses

In synthesis of chloromethylated compounds, plastics and ion-exchange resins.

Definition

ChEBI: Chloromethyl methyl ether is an ether.

Hazard

Flammable, dangerous fire and explosion risk. Toxic by ingestion and inhalation. TLV: Suspected human carcinogen.

Health Hazard

The acute toxicity of chloromethyl methyl ether is moderate to high. Inhalation of the vapor is severely irritating to the eyes, skin, nose, and respiratory tract, and causes sore throat, fever, chills, and difficulty breathing. Exposure to high concentrations can lead to delayed pulmonary edema, which can be fatal. Eye or skin contact with the liquid can result in severe and painful burns. Ingestion of this substance may lead to severe burns of the mouth and stomach and can be fatal. Chloromethyl methyl ether is regulated by OSHA as a carcinogen (29 CFR 1910.1006) and is listed in IARC Group 1 ("carcinogenic to humans"). This substance is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. Note also that some commercial samples of chloromethyl methyl ether contain up to 7% of highly carcinogenic bis(chloromethyl) ether. Hydrolysis of chloromethyl methyl ether produces HCl and formaldehyde, which can recombine to form bis(chloromethyl) ether. No information is available on the reproductive and developmental toxicity of chloromethyl methyl ether. Odor does not provide adequate warning of the harmful presence of this carcinogenic substance.

Health Hazard

CMME is a moderately toxic compoundwith cancer-causing action. The inhalationtoxicity of this compound, like that of otherlower aliphatic haloethers, is greater thanthe acute oral or dermal toxicity. It is lesstoxic than dichloroethers. Exposure to thiscompound can cause irritation of the eyes,nose, and throat. At high concentrations, lunginjury can occur
LC50 value, inhalation (rats): 180 mg (55ppm)/m³/7 hr
LD50 value, oral (rats): 817 mg/kg
CMME was found to be carcinogenic intest animals by inhalation and subcutaneousapplications. It produced lung and endocrinetumors. In humans its exposure can causelung cancer.

Fire Hazard

Chloromethyl methyl ether is highly flammable. Fires involving this substance should be extinguished with carbon dioxide or dry chemical extinguishers.

Flammability and Explosibility

Chloromethyl methyl ether is highly flammable. Fires involving this substance should be extinguished with carbon dioxide or dry chemical extinguishers.

Safety Profile

Confirmed human carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Poison by inhalation. Moderately toxic by ingestion. Human mutation data reported. A very dangerous fire hazard when exposed to heat or flame. To fight fire, use alcohol foam,water, CO2, or dry chemical. Reaction with dvalent metals forms a very reactive product. When heated to decomposition it emits toxic fumes of Cl-. See also ETHERS and CHLORINATED HYDROCARBONS, ALIPHATIC.

Potential Exposure

Chloromethyl. methyl ether is a highly reactive methylating agent and is used in the chemical industry for synthesis of organic chemicals. Most industrial operations are carried out in closed process vessels so that exposure is minimized.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin,remove contaminated clothing and wash immediately withsoap and water. Seek medical attention immediately. If thischemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart actionhas stopped. Transfer promptly to a medical facility. Whenthis chemical has been swallowed, get medical attention.Give large quantities of water and induce vomiting. Do notmake an unconscious person vomit. Medical observation isrecommended for 24-48 h after breathing overexposure, aspulmonary edema may be delayed. As first aid for pulmonaryedema, a doctor or authorized paramedic may consideradministering a corticosteroid spray

Carcinogenicity

Technical-grade chloromethyl methyl ether (CMME) are known to be human carcinogens based on sufficient evidence of carcinogenicity from studies in humans.

storage

work with this substance should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and splash goggles should be worn at all times to prevent skin and eye contact. Chloromethyl methyl ether is also highly flammable and should be used only in areas free of ignition sources; quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers in secondary containers.

Shipping

UN1239 Methyl chloromethyl ether, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, Inhalation Hazard Zone A. PGI.

Purification Methods

If suspect (check IR), shake it with saturated aqueous CaCl2 solution, dry over CaCl2 and fractionally distil taking middle fraction. [Marvel & Porter Org Synth Coll Vol I 377 1941, Beilstein 1 H 580, 1 I 304, 1 II 645, 1 III 2587, 1 IV 3046.] VERY TOXIC and CARCINOGENIC.

Incompatibilities

May form explosive mixture with air. May be able to form unstable and explosive peroxides on contact with oxygen. Contact with (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Decomposes on contact with water, forming hydrochloric acid and formaldehyde. Attacks various metals in presence of water.

Waste Disposal

Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.