ChemicalBook > CAS DataBase List > STF 31

STF 31

Product Name
STF 31
CAS No.
724741-75-7
Chemical Name
STF 31
Synonyms
STF 31;CS-1575;STF31;STF 31;N'-(4-METHYLPHENYL)-4-PYRIDINECARBOXIMIDAMIDE;4-((4-(tert-Butyl)phenylsulfonamido)methyl)-N-(pyridin-3-yl)benzamide; 4-[[(4-tert-butylphenyl)sulfonylamino]methyl]-N-pyridin-3-ylbenzamide;4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-benzamide;Benzamide, 4-[[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-;VHL,inhibitor,RCC4/VHL,STF31,Autophagy,STF 31,STF-31,GLUT,Glucose transporter,GLUT1,inhibit,glucose,RCC4
CBNumber
CB12663075
Molecular Formula
C23H25N3O3S
Formula Weight
423.53
MOL File
724741-75-7.mol
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STF 31 Property

Density 
1.247±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble20mg/mL, clear
pka
11.28±0.50(Predicted)
form 
powder
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
46
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1108
Product name
STF-31
Purity
≥98% (HPLC)
Packaging
5mg
Price
$149
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1108
Product name
STF-31
Purity
≥98% (HPLC)
Packaging
25mg
Price
$594
Updated
2024/03/01
Cayman Chemical
Product number
11173
Product name
STF-31
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
11173
Product name
STF-31
Purity
≥98%
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
11173
Product name
STF-31
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
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STF 31 Chemical Properties,Usage,Production

Description

Glucose transporter 1 (Glut1) is an inducible carrier of pentoses and hexoses, including glucose. STF-31 is an inhibitor of Glut1 (IC50 = ~1 μM) that blocks glucose uptake. It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene, which overexpress Glut1. Although STF-31 binds Glut1, suggesting a direct effect, STF-31 also inhibits nicotinamide phosphoribosyltransferase, an enzyme that induces Glut1 expression. STF-31 is also toxic to human pluripotent stem cells (hPSCs) and can be used to selectively eliminate hPSCs from mixed cultures.

Uses

STF 31 is used in biological studies as pyridylanilinothiazoles and pyridylphenylsulfonyl benzamides scaffolds use to prepare affinity chromatoraphy reagents for cancer targeting. STF 31 is an inhibitor of GLUT1 which blocks glucose uptake.

Biochem/physiol Actions

STF-31 selectively inhibits the glucose transporter GLUT1 and selectively impairs cancer cell growth of kidney and other types of cancer cells that lack the von Hippel-Lindau (VHL) tumor suppressor protein. Inactivation of VHL increases the activity of hypoxia-inducible factor transcription factor HIF, which in turn stimulates the transcription of genes involved in glucose metabolism, including the GLUT1 gene. VHL-deficient cancer cells, which include about 80% of renal cell carcinomas, are dependent on the high affinity GLUT1 transporter and aerobic glycolysis for ATP production. STF-31 binds directly to the GLUT1 transporter, blocking glucose uptake, resulting in necrosis in VHL-deficient cancer cells, but not in normal cells or cancer cells with intact VHL.

storage

Store at RT

References

1) Chan?et al. (2011),?Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality; Sci. Transl. Med.,?3?94ra70 2) Adams?et al., (2014),?NAMPT is the Cellular Target of STF-31-Like Small-Molecule Probes; ACS Chem. Biol.,?9?2447 3) Dragovich?et al. (2014),?Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphribosyltransferase (NAMPT); Bioorg. Med. Chem. Lett.,?24?954 4)Kraus?et al.?(2018),?Targeting glucose transport and the NAD pathway in tumor cells with STF-31: a re-evaluation; Cell Oncol.(Dordr)?41?485

STF 31 Preparation Products And Raw materials

Raw materials

Preparation Products

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STF 31 Suppliers

China 88 India 1 United Kingdom 2 United States 16 Global 107
MedChemexpress LLC
Tel
021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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4861
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EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
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United States
ProdList
8447
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60
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
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60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
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United States
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6391
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
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58
ApexBio Technology
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sales@apexbt.com
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United States
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6251
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58
BOC Sciences
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16314854226
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info@bocsci.com
Country
United States
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9923
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65
Focus Biomolecules
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sales@focusbiomolecules.com
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United States
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Cayman Chemical Company
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cayman@caymanchem.com
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United States
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United States Biological
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chemicals@usbio.net
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MedChemExpress
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sales@medchemexpress.com
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6398
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Riedel-de Haen AG
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International Laboratory Limited
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admin@intlab.org
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View Lastest Price from STF 31 manufacturers

Career Henan Chemical Co
Product
4-[[(4-tert-butylphenyl)sulfonylamino]methyl]-N-pyridin-3-ylbenzamide 724741-75-7
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-30

724741-75-7, STF 31Related Search:

Geldanamycin TCPOBOP Adapalene AAL-993

  • STF 31
  • 4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-benzamide
  • N'-(4-METHYLPHENYL)-4-PYRIDINECARBOXIMIDAMIDE
  • 4-[[(4-tert-butylphenyl)sulfonylamino]methyl]-N-pyridin-3-ylbenzamide
  • STF31;STF 31
  • CS-1575
  • Benzamide, 4-[[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-
  • 4-((4-(tert-Butyl)phenylsulfonamido)methyl)-N-(pyridin-3-yl)benzamide
  • VHL,inhibitor,RCC4/VHL,STF31,Autophagy,STF 31,STF-31,GLUT,Glucose transporter,GLUT1,inhibit,glucose,RCC4
  • 724741-75-7
  • 72474-75-7
  • Inhibitors
  • API