6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one

ChemicalBook > CAS DataBase List > 6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one

6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one

Product Name: 6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one
CAS No.: 1286739-19-2
Chemical Name: 6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one
Synonyms: CS-1774;FRAX597;FRAX597, >=98%;FRAX 597;FRAX-597;FRAX597;FRAX597,FRAX-597,p21 activated kinases,FRAX 597,Inhibitor,inhibit,PAK;6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-7-one;6-(2-chloro-4-(thiazol-5-yl)phenyl)-8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrido[2,3-d]pyrimidin-7(8H)-one;6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one;6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one;Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-[2-chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-
CBNumber: CB12663792
Molecular Formula: C29H28ClN7OS
Formula Weight: 558.1
MOL File: 1286739-19-2.mol

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6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one Property

Melting point:: >220°C (dec.)
storage temp.: Refrigerator
solubility: DMSO (Slightly)
form: Solid
color: Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.33379
Product name: p21-Activated Kinase Inhibitor III, FRAX597 - CAS 1286739-19-2 - Calbiochem
Packaging: 5MG
Price: $184
Updated: 2023/06/20

Cayman Chemical

Product number: 22205
Product name: FRAX597
Purity: ≥98%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 22205
Product name: FRAX597
Purity: ≥98%
Packaging: 5mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 22205
Product name: FRAX597
Purity: ≥98%
Packaging: 10mg
Price: $238
Updated: 2024/03/01

Cayman Chemical

Product number: 22205
Product name: FRAX597
Purity: ≥98%
Packaging: 25mg
Price: $547
Updated: 2024/03/01

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6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one Chemical Properties,Usage,Production

Uses

p21-activated kinases (Paks) are serine/threonine protein kinases involved in cellular signaling pathways. PAK1 is an effector of Rho GTPase. PAKs are oncogenic kinases, which have been implicated as potential therapeutic targets. FRAX 597 is a PAK1 inhibitor that can reduce pancreatic cancer growth when used with Gemcitabine (G305000), an antineoplastic agent.

Biological Activity

frax597 is a small-molecule inhibitor of the group 1 p21-activated kinases (paks) with ic50 values of 8nm, 13nm and 19nm, respectively for pak1, pak2 and pak3 [1].the paks family includes two sub groups: 1 and 2. these kinases take participate in the growth of various types of cancers. frax597 is developed to be an inhibitor of group 1 paks from the initial hits of a high throughput screen. it is an atp-competitive inhibitor of pak 1-3. to group 2 paks, frax597 shows minimal inhibitory activity. the inhibition mechanism of frax597 is that it binds pak by targeting the atp binding site and competes with atp. frax597 is reported to suppress cell proliferation by arresting cell cycle in g1 without impacting cell viability in schwann cells. in vivo assay also demonstrates frax597 can suppress tumor growth in an orthotopic model of nf2. this effect on the cells has been proved to be mediated through the inhibition of the group i paks [1].

target

PAK1

storage

Store at -20°C

References

[1] silvia licciulli, jasna maksimoska, chun zhou, scott troutman, smitha kota, qin liu, sergio duron, david campbell, jonathan chernoff, jeffery field, ronen marmorstein and joseph l. kissil. frax597, a small molecule inhibitor of the p21-activated kinases, inhibits schwannomas tumorigenesis of nf2-associated. j. biol. chem. 2013, august.

6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one Suppliers

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1286739-19-2, 6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-oneRelated Search:

Thiazovivin Bafetinib Bosutinib Linsitinib SB 431542 Vismodegib (GDC-0449)

6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one

FRAX597

Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-[2-chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-

CS-1774

FRAX 597;FRAX-597;FRAX597

6-(2-chloro-4-(thiazol-5-yl)phenyl)-8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrido[2,3-d]pyrimidin-7(8H)-one

6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one

FRAX597, >=98%

6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-7-one

6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one USP/EP/BP

FRAX597,FRAX-597,p21 activated kinases,FRAX 597,Inhibitor,inhibit,PAK

1286739-19-2

C29H28ClN7OS

Inhibitors

API