(5-Bromo-3-chloropyridin-2-yl)methanol
- Product Name
- (5-Bromo-3-chloropyridin-2-yl)methanol
- CAS No.
- 1206968-88-8
- Chemical Name
- (5-Bromo-3-chloropyridin-2-yl)methanol
- Synonyms
- (5-Bromo-3-chloro-2-pyridyl)methanol;2-Pyridinemethanol, 5-bromo-3-chloro-;(5-Bromo-3-chloropyridin-2-yl)methanol
- CBNumber
- CB12664779
- Molecular Formula
- C6H5BrClNO
- Formula Weight
- 222.47
- MOL File
- 1206968-88-8.mol
(5-Bromo-3-chloropyridin-2-yl)methanol Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystals
- color
- White
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B417180
- Product name
- (5-Bromo-3-chloropyridin-2-yl)methanol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 189278
- Product name
- (5-Bromo-3-chloropyridin-2-yl)methanol
- Packaging
- 500mg
- Price
- $826
- Updated
- 2021/12/16
- Product number
- 189278
- Product name
- (5-Bromo-3-chloropyridin-2-yl)methanol
- Packaging
- 1g
- Price
- $1350
- Updated
- 2021/12/16
- Product number
- 5671DP
- Product name
- (5-Bromo-3-chloropyridin-2-yl)methanol
- Packaging
- 25g
- Price
- $2499
- Updated
- 2021/12/16
- Product number
- 189278
- Product name
- (5-Bromo-3-chloropyridin-2-yl)methanol
- Packaging
- 5g
- Price
- $4050
- Updated
- 2021/12/16
(5-Bromo-3-chloropyridin-2-yl)methanol Chemical Properties,Usage,Production
Synthesis
160599-70-2
68-12-2
1206968-88-8
[Example 14] Synthesis of (5-bromo-3-chloropyridin-2-yl)methanol (1) Dissolve 3-chloro-2,5-dibromopyridine (2.26 g, 8.3 mmol) in toluene (83 mL) under nitrogen protection and cool to -78 °C. A n-hexane solution of 1.6 M n-butyllithium (6.23 mL, 9.96 mmol) was slowly added dropwise, keeping the temperature at -78 °C. After the reaction mixture was stirred at -78 °C for 2 h, anhydrous N,N-dimethylformamide (1.29 mL, 16.6 mmol) was added. Subsequently, the reaction mixture was slowly warmed to room temperature and methanol (83 mL) and sodium borohydride (314 mg, 8.3 mmol) were added. After stirring for 30 min at room temperature, the reaction was quenched by the addition of saturated ammonium chloride solution and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 4/1) to give pale yellow crystalline (5-bromo-3-chloropyridin-2-yl)methanol (967 mg, 52% yield). 1H NMR (CDCl3, 400 MHz): δ= 3.93 (1H, br s), 4.75 (2H, s), 7.86 (1H, d, J=2 Hz), 8.56 (1H, br s).
References
[1] Patent: EP2474540, 2012, A1. Location in patent: Page/Page column 32
(5-Bromo-3-chloropyridin-2-yl)methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (5-Bromo-3-chloropyridin-2-yl)methanol manufacturers
- Product
- (5-Bromo-3-chloropyridin-2-yl)methanol 1206968-88-8
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08