ChemicalBook > CAS DataBase List > CC 930

CC 930

Product Name: CC 930
CAS No.: 899805-25-5
Chemical Name: CC 930
Synonyms: CC930;CC 930;MCC930;CC-930;CS-1152;Tanziser;Tanzisertib;CC-930(Tanzisertib);TANZISERTIB (CC-930);TANZISERTIB; CC930; CC 930
CBNumber: CB12666607
Molecular Formula: C21H23F3N6O2
Formula Weight: 448.44
MOL File: 899805-25-5.mol

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CC 930 Property

Boiling point:: 626.4±65.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 15.05±0.40(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22466
Product name: CC-930
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 22466
Product name: CC-930
Purity: ≥98%
Packaging: 5mg
Price: $155
Updated: 2024/03/01

Cayman Chemical

Product number: 22466
Product name: CC-930
Purity: ≥98%
Packaging: 10mg
Price: $274
Updated: 2024/03/01

Cayman Chemical

Product number: 22466
Product name: CC-930
Purity: ≥98%
Packaging: 25mg
Price: $595
Updated: 2024/03/01

TRC

Product number: T007100
Product name: Tanzisertib
Packaging: 5mg
Price: $150
Updated: 2021/12/16

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CC 930 Chemical Properties,Usage,Production

Uses

Tanzisertib is a potent, selective, and orally active c-Jun amino-terminal kinase (JNK) inhibitor used for treatment of dermal fibrosis.

Biological Activity

Tanzisertib (CC-930, JNK-930, JNKI-1) has an ATP-competitive inhibitory effect on the phosphorylation of the JNK-dependent protein substrate c-Jun and all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM), selective inhibition of ERK1 and p38a with IC50 of 0.48 μM and 3.4 μM, respectively .

in vivo

In the acute PK-PD rat model of LPS-induced TNFα production, oral administration of 10 mg/kg and 30 mg/kg of CC-930 reduced the production of TNFα in vivo by 23% and 77%, respectively. CC-930 is well tolerated in vivo and its effect is proportional to dose.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> JNK1
(Cell-free assay)

Target	Value
JNK3 (Cell-free assay)	0.006 μM
JNK2 (Cell-free assay)	0.007 μM
0.061 μM

IC 50

JNK3: 6 nM (IC₅₀); JNK2: 7 nM (IC₅₀); JNK1: 61 nM (IC₅₀)

CC 930 Preparation Products And Raw materials

Raw materials

Preparation Products

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CC 930 Suppliers

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899805-25-5, CC 930Related Search:

MCC930

CC 930

CC930

CC-930

Tanzisertib

trans-4-[[9-[(3S)-Tetrahydro-3-furanyl]-8-[(2,4,6-trifluorophenyl)amino]-9H-purin-2-yl]amino]cyclohexanol

4-[[9-[(3s)-oxolan-3-yl]-8-(2,4,6-trifluoroanilino)purin-2-yl]amino]cyclohexan-1-ol

TANZISERTIB (CC-930)

Tanzisertib(CC-930) (free base)

TANZISERTIB; CC930; CC 930

CC-930(Tanzisertib)

CS-1152

Cyclohexanol, 4-[[9-[(3S)-tetrahydro-3-furanyl]-8-[(2,4,6-trifluorophenyl)amino]-9H-purin-2-yl]amino]-, trans-

trans-4-((9-((S)-tetrahydrofuran-3-yl)-8-((2,4,6-trifluorophenyl)amino)-9H-purin-2-yl)amino)cyclohexanol

Tanzisertib,Inhibitor,inhibit,CC 930,CC930,JNK

Tanziser

Tanzisertib, 10 mM in DMSO

(1s,4r)-4-((9-((s)-tetrahydrofuran-3-yl)-8-((2,4,6-trifluorophenyl)amino)-9h-purin-2-yl)amino)cyclohexan-1-ol

899805-25-5

C21H23F3N6O2

MAPK