ChemicalBook > CAS DataBase List > KN93 hydrochloride

KN93 hydrochloride

Product Name
KN93 hydrochloride
CAS No.
1956426-56-4
Chemical Name
KN93 hydrochloride
Synonyms
CS-1449;KN-93 HCl;KN-93-HCI;KN-93 HCI;KN93 (HCI);KN-93 (HCI);KN93 hydrochloride;KN 93 hydrochloride;KN-93 (hydrochloride);N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide hydrochloride
CBNumber
CB12666647
Molecular Formula
C26H30Cl2N2O4S
Formula Weight
537.5
MOL File
1956426-56-4.mol
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KN93 hydrochloride Property

storage temp. 
Store at -20°C
solubility 
DMF:10.0(Max Conc. mg/mL);18.6(Max Conc. mM)
DMSO:20.5(Max Conc. mg/mL);38.14(Max Conc. mM)
Water:0.45(Max Conc. mg/mL);0.84(Max Conc. mM)
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13864
Product name
KN-93 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$107
Updated
2024/03/01
Cayman Chemical
Product number
13864
Product name
KN-93 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$471
Updated
2024/03/01
Cayman Chemical
Product number
13864
Product name
KN-93 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$836
Updated
2024/03/01
Biorbyt Ltd
Product number
orb611908
Product name
KN-93 HCl
Purity
>98%
Packaging
100mg
Price
$646
Updated
2021/12/16
ChemScene
Product number
CS-1561
Product name
KN-93hydrochloride
Purity
99.43%
Packaging
50mg
Price
$720
Updated
2021/12/16
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KN93 hydrochloride Chemical Properties,Usage,Production

Biological Activity

KN93 hydrochloride is a cell-permeable, reversible and competitive inhibitor of calmodulin-dependent kinase type II (CaMKII) with Ki of 370 nM.

in vitro

After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN93 release, a peak of cells had progressed into S and G2-M. KN93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts.

target

Ki: 370 nM (CaMK-II)

KN93 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1956426-56-4, KN93 hydrochlorideRelated Search:


  • KN 93 hydrochloride
  • KN-93 (hydrochloride)
  • KN93 hydrochloride
  • KN-93 HCl
  • CS-1449
  • KN93 (HCI)
  • KN-93 (HCI)
  • KN-93 HCI
  • KN-93-HCI
  • N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide, monohydrochloride
  • N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide hydrochloride
  • 1956426-56-4
  • C26H30Cl2N2O4S