Teneligliptin Hydrobromide

ChemicalBook > CAS DataBase List > Teneligliptin Hydrobromide

Teneligliptin Hydrobromide

Product Name: Teneligliptin Hydrobromide
CAS No.: 906093-29-6
Chemical Name: Teneligliptin Hydrobromide
Synonyms: Teneligliptin HydrobroMide Hydrate;Teneligliptin HBr;3-(((2s,4s)-4-(4-(3-Methyl-1-phenyl-1h-pyrazol-5-yl)-1-piperazinyl)-2-pyrrolidinyl)carbonyl)-thiazolidine hydrobromide (2:5) X H2O;API(Teneligliptin hydro bromide hydrate);3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]-thiazolidine hydrobromide (2:5);[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone,pentahydrobromide;MP-513 (hydrobromide);Ticagrelor hydrobromide;Tepagliptin (Hydrobromide);Teneligliptin (hydrobroMide)
CBNumber: CB12666692
Molecular Formula: C22H31BrN6OS
Formula Weight: 507.5
MOL File: 906093-29-6.mol

Less

Teneligliptin Hydrobromide Property

Melting point:: >211°C (dec.)
storage temp.: Refrigerator
solubility: Methanol (Slightly)
form: Solid
color: White to Light Beige
optical activity: [α]/D -28 to -36°, c =0.5 in methanol
Water Solubility: H2O: 2mg/mL, clear

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TRC

Product number: T018300
Product name: TeneligliptinHydrobromide(2:5)
Packaging: 25mg
Price: $130
Updated: 2021/12/16

ApexBio Technology

Product number: A3865
Product name: Teneligliptinhydrobromide
Packaging: 50mg
Price: $160
Updated: 2021/12/16

ChemScene

Product number: CS-1098
Product name: Teneligliptinhydrobromide
Purity: 99.95%
Packaging: 50mg
Price: $180
Updated: 2021/12/16

Ark Pharm

Product number: P000458428
Product name: Teneligliptin Hydrobromide
Purity: 98+%
Packaging: 50mg
Price: $233
Updated: 2021/12/16

AK Scientific

Product number: J97802
Product name: Teneligliptinhydrobromide
Packaging: 100mg
Price: $252
Updated: 2021/12/16

Less

Teneligliptin Hydrobromide Chemical Properties,Usage,Production

Uses

Teneligliptin Hydrobromide (2:5) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.

Biological Activity

teneligliptin hydrobromide is a novel, potent, and long-lasting dipeptidyl peptidase-4 (dpp-4) inhibitor with antioxidant properties; competitively inhibited human plasma, rat plasma, and human recombinant dpp-4 in vitro, with ic50 values of about 1 nm[1].dpp4 is also known as adenosine deaminase complexing protein 2 or cd26. dpp4 is an antigenic enzyme expressed on the membrane of most cell types and is associated with immune regulation, signal transduction and apoptosis [2].

Clinical Use

Teneligliptin is a DPP-4 inhibitor which was approved in Japan in 2012 for the treatment of type II diabetes. It was discovered and developed by Mitsubishi Tanabe Pharma under the trade name Tenelia®. Similar to other marketed DPP-4 inhibitors, teneligliptin was well tolerated in all studies and QD dosing produced a long-lasting inhibitory action against DPP-4 and an increase in active GLP-1 levels, with very low rates of renal excretion.

Synthesis

The only reported synthesis of teneligliptin is described in the scheme below. Reaction of commercially available N-Boc-piperazine (158) with diketene (159) in DMF at room temperature gave acetoacetamide 160 in 86% yield, and this material was immediately condensed with phenylhydrazine in methanesulfonic acid followed by a cyclodehydration with phosphorus oxychloride to give pyrazole 161 in 12% yield. The t-butyl carbamate was then removed with TFA in dichloromethane to give amine 162 in 88% yield. This amine was then subjected to butyrolactam 165 (which was prepared from N-Boctrans- 4-hydroxy-L-proline (163) coupled with thiazolidine (164) under conventional amide-forming conditions using EDC) in the presence of sodium triacetoxy borohydride (STAB-H) in acetic acid. This reductive amination reaction afforded the cis-aminopyrrolidine 166 exclusively in 50% yield. Removal of the t-butyl carbamate group with TFA afforded the teneligliptin free amine in 93% yield, and this freebase was then subsequently treated with 48% hydrobromic acid in refluxing ethanol to give teleligliptin hydrobromide hydrate (XXV) in 90% yield.

in vitro

in human umbilical vein endothelial cells, teneligliptin promoted the antioxidant response, reduced ros levels and induced nrf2-target genes messenger ribonucleic acid expression. teneligliptin improved proliferation rates in huvecs exposed to high glucose, regulating the expression of cell-cycle inhibitors markers (p21, p53 and p27), and reducing proapoptotic genes (bax and casp3), while promoteed bcl2 expression. teneligliptin ameliorated high glucose-induced endoplasmic reticulum stress. teneligliptin exihibited antioxidant properties and overcome the metabolic memory effect induced by chronic exposure to high glucose in huvecs[3].

in vivo

in teneligliptin-treated mice, serum alanine aminotransferase and intrahepatic triglyceride levels were significantly decreased (p < 0.05). teneligliptin also significantly downregulated hepatic mrna levels of the genes involved in de novo lipogenesis (p < 0.05). moreover, the hepatic expression levels of phosphorylated amp-activated protein kinase (ampk) protein were upregulated by teneligliptin[4]. orally administration of teneligliptin at a dosage of 20 mg once daily in adults in the ovariectomized (ovx) mice maintained on a high-fat diet, teneligliptin effectively ameliorated the characteristics of metabolic abnormalities associated with postmenopausal obesity. teneligliptin ameliorated the decreased energy consumption in the dark and light phases, reduced locomotor activity in the dark phase, and lowered core body temperature in ovx-hf[5].

References

[1] kishimoto m. teneligliptin: a dpp-4 inhibitor for the treatment of type 2 diabetes[j]. diabetes, metabolic syndrome and obesity: targets and therapy, 2013, 6: 187.
[2] kameoka j, tanaka t, nojima y, et al. direct association of adenosine deaminase with a t cell activation antigen, cd26[j]. science, 1993, 261(5120): 466-469.
[3] pujadas g, de nigris v, prattichizzo f, et al. the dipeptidyl peptidase-4 (dpp-4) inhibitor teneligliptin functions as antioxidant on human endothelial cells exposed to chronic hyperglycemia and metabolic high-glucose memory[j]. endocrine, 2016: 1-12.
[4] ideta t, shirakami y, miyazaki t, et al. the dipeptidyl peptidase-4 inhibitor teneligliptin attenuates hepatic lipogenesis via ampk activation in non-alcoholic fatty liver disease model mice[j]. international journal of molecular sciences, 2015, 16(12): 29207-29218.
[5] sameshima a, wada t, ito t, et al. teneligliptin improves metabolic abnormalities in a mouse model of postmenopausal obesity[j]. journal of endocrinology, 2015, 227(1): 25-36.

Teneligliptin Hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Teneligliptin Hydrobromide Suppliers

China 163 India 14 United States 14 Global 191

Hefei HomeSunshine Pharmaceutical Technology Co., Ltd.

Tel: 0551-65523315 17705606359
Fax: 0551-65523375
Email: errol@homesunshinepharma.com
Country: China
ProdList: 71
Advantage: 58

Nanjing Yunzhi Xinhe Biotechnology Co., Ltd

Tel: 19852363252; 19852363252
Email: 2634809846@qq.com
Country: China
ProdList: 53
Advantage: 58

SuZhou Medinoah Co.,LTD.

Tel: 0512-69561983 13914027025
Fax: 0512-69561982
Email: zhang_q@medinoah.com
Country: China
ProdList: 4098
Advantage: 58

Jiangsu Xinglin Pharmaceutical Co., Ltd

Tel: 18036652731
Email: 476682145@qq.com
Country: China
ProdList: 55
Advantage: 58

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9510
Advantage: 66

Nanjing Chemlin Chemical Co., Ltd

Tel: 19951945301
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19185
Advantage: 64

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-83725681-603
Fax: +86 755 28094224
Country: China
ProdList: 4496
Advantage: 50

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9545
Advantage: 55

China Nobel Chem Co., Limited

Tel: +86(0)21 60484900
Fax: +86(0)21 60484900
Country: China
ProdList: 764
Advantage: 50

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Conier Chem & Pharma Co.,Ltd,

Tel: 023-62879767 13996269627;
Fax: +86-28-84559521
Email: sales@conier.com
Country: China
ProdList: 299
Advantage: 56

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9978
Advantage: 55

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9648
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10274
Advantage: 55

Shandong Boluoda Biological Technology Co., Ltd.

Tel: 0531-68652053
Email: 2310993908@qq.com
Country: China
ProdList: 1556
Advantage: 58

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

INTERCHEMIE NANJING PHARMATECH CO., LTD

Tel: 13656237714 13656237714
Fax: 0512-65852853
Email: xiaokunfu@kyyykj.com
Country: China
ProdList: 297
Advantage: 55

Shanghai Rochi Pharmaceutical Co., Ltd.

Tel: 021-38751876 15000076078
Fax: 021-50275764
Email: Info@rochipharma.com
Country: China
ProdList: 568
Advantage: 55

Wuhan Bo-Sen Biological Technology Co., Ltd

Tel: 027-51335350 15107175693
Fax: 027-51335350
Email: bosenyuan@foxmail.com
Country: China
ProdList: 192
Advantage: 55

Nanjing XiLang Chemical Products Co., Ltd.

Tel: 18936048580
Email: chemxilang@163.com
Country: China
ProdList: 3994
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Fax: 0317-5106596
Email: sale@enkepharma.com
Country: China
ProdList: 2007
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10214
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29764
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-59402396 13419635609
Fax: 027-83989310
Email: 13419635609@163.com
Country: China
ProdList: 1958
Advantage: 55

Guangzhou Kafen Biotech Co.,Ltd

Tel: 18029243487 2355327168
Fax: 020-31121510
Email: gy@yccreate.com
Country: China
ProdList: 4749
Advantage: 55

Hefei Hirisun Pharmatech Co., Ltd.

Tel: +86-0551-62678551 +86-15056975894
Fax: 0551-62678551
Email: sales@hirisunpharm.com
Country: China
ProdList: 181
Advantage: 55

Henan Anky Chemical Technology Co., Ltd.

Tel: 17836913271
Fax: 0374-8348899
Email: 3224305243@qq.com
Country: China
ProdList: 2921
Advantage: 58

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9578
Advantage: 60

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9590
Advantage: 58

Wuhan NewBaiChuan Pharmaceutical Co., Ltd.

Tel: 027-50476178
Fax: QQ644526144
Email: 644526144@qq.com
Country: China
ProdList: 418
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52693
Advantage: 58

Wuhan Xinbaichuan Pharmaceutical Technology Co., Ltd.

Tel: 027-50478167
Fax: QQ 252994272
Email: 252994272@qq.com
Country: China
ProdList: 277
Advantage: 58

Shenzhen Botel Biotechnology Co. Ltd.

Tel: 0755-22202135 13316968096
Email: 1979313431@qq.com
Country: China
ProdList: 9120
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Wisdom Drugs Co., Ltd.

Tel: 18261161868
Email: 527536256@qq.com
Country: China
ProdList: 683
Advantage: 58

Aishilun biotechnology (Shanghai) co., LTD

Tel: 021-50676523 18019098996
Email: info@acelybio.com
Country: China
ProdList: 3960
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7824
Advantage: 58

CR Corporation Limited

Tel: +8613062833949
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 8647
Advantage: 58

Finetech Industry Limited

Tel: +86-27-87465837 +8618971612321
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9639
Advantage: 58

Shanghai UCHEM Inc.

Tel: +862156762820 +86-13564624040
Email: sales@myuchem.com
Country: China
ProdList: 7709
Advantage: 58

Less

View Lastest Price from Teneligliptin Hydrobromide manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Teneligliptin Hydrobromide 906093-29-6
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-09-05

Nanjing Fred Technology Co., Ltd

Product: Teneligliptin Hydrobromide 906093-29-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%, Single impurity＜0.1
Supply Ability: 1 ton
Release date: 2024-01-02

Hangzhou Hyper Chemicals Limited

Product: Teneligliptin Hydrobromide 906093-29-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%, USP
Supply Ability: 5,000KG
Release date: 2024-08-22

906093-29-6, Teneligliptin HydrobromideRelated Search:

Teneligptin API 1-Pyrrolidinecarboxylic acid, 4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4R)- 1-Pyrrolidinecarboxylic acid, 4-oxo-2-(3-thiazolidinylcarbonyl)-, 1,1-diMethylethyl ester, (2R)- Unii-4bmh7izt98 Aprepitant Repaglinide Calcium levofolinate Sofosbuvir Levetiracetam Levofloxacin Rivaroxaban ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) AGOMELATINE Linagliptin Alogliptin benzoate Trelagliptin Vonoprazan fumarate Trelagliptin succinate

[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone,pentahydrobromide

API(Teneligliptin hydro bromide hydrate)

3-(((2s,4s)-4-(4-(3-Methyl-1-phenyl-1h-pyrazol-5-yl)-1-piperazinyl)-2-pyrrolidinyl)carbonyl)-thiazolidine hydrobromide (2:5) X H2O

Teneligliptin (hydrobroMide)

Teneligliptin HydrobroMide Hydrate

3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]-thiazolidine hydrobromide (2:5)

Teneligliptin HydrobroMide (2:5)

Teneligliptin HBr

MP-513 (hydrobromide)

Teneligliptin hydrobromide anhydrous

TENELIGLIPTIN HEMIPENTA HYDROBROMIDE HYDRATE

((2S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanone

3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piper...

Teneligliptin hydrobromideQ: What is Teneligliptin hydrobromide Q: What is the CAS Number of Teneligliptin hydrobromide Q: What is the storage condition of Teneligliptin hydrobromide Q: What are the applications of Teneligliptin hydrobromide

Teneligliptin Hydrobromide API

Teneligliptin(hydrobromide)-amorphous

Bis(((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanone) pentahydrobromide

Methanone, [(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-, hydrobromide (2:5)

(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-Methanone hydrobromide (2:5)

Ticagrelor hydrobromide

Teneligliptin HBr [(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]- 2-pyrrolidinyl]-3-thiazolidinylmethanone HBr

Tepagliptin (Hydrobromide)

906093-29-6

C44H65Br5N12O2S2

2C22H30N6OS5HBr

2C22H30N6OS5BrH

API