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Flumatinib mesylate

Product Name
Flumatinib mesylate
CAS No.
895519-91-2
Chemical Name
Flumatinib mesylate
Synonyms
CS-1023;HHGV678 mesylate;FluMatinib Mesylate;Flumatinib mesylate (HHGV-678);Flumatinib mesylate, 10 mM in DMSO;N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl);N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide methanesulfonate;methanesulfonic acid,4-[(4-methylpiperazin-1-yl)methyl]-N-[6-methyl-5-[(4-pyridin-3-ylpyrimidin-2-yl)amino]pyridin-3-yl]-3-(trifluoromethyl)benzamide;HHGV-678,PDGFRβ,HHGV678,c-Abl,Bcr-Abl,Platelet-derived growth factor receptor,PDGFR,HHGV 678,SCFR,Flumatinib mesylate,c-Kit,Flumatinib,CD117,Inhibitor,inhibit;BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI)
CBNumber
CB12667200
Molecular Formula
C30H33F3N8O4S
Formula Weight
658.6944296
MOL File
895519-91-2.mol
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Flumatinib mesylate Property

storage temp. 
Store at -20°C
solubility 
H2O : 50 mg/mL (75.91 mM; Need ultrasonic)DMSO : 50 mg/mL (75.91 mM; Need ultrasonic)
form 
Powder
color 
Light brown to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
A8691
Product name
Flumatinibmesylate
Packaging
500mg
Price
$91
Updated
2021/12/16
ChemScene
Product number
CS-1826
Product name
Flumatinib(mesylate)
Purity
99.97%
Packaging
500mg
Price
$120
Updated
2021/12/16
ApexBio Technology
Product number
A8691
Product name
Flumatinibmesylate
Packaging
1g
Price
$155
Updated
2021/12/16
Crysdot
Product number
CD31000381
Product name
Flumatinibmesylate
Purity
98+%
Packaging
250mg
Price
$47
Updated
2021/12/16
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Flumatinib mesylate Chemical Properties,Usage,Production

Uses

Flumatinib (HHGV678) mesylate is an orally active and selective inhibitor of Bcr-Abl. Flumatinib mesylate inhibits c-Abl, PDGFRβ and c-Kit with IC50 values of 1.2, 307.6 and 665.5 nM, respectively. Flumatinib mesylate inhibits Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation. Flumatinib mesylate inhibits tumor growth in chronic myelogenous leukemia model[1][2].

Synthesis

Synthesis of Flumatinib Mesylate

in vivo

Flumatinib mesylate (HH-GV-678) (18-75 mg/kg; p.o.; Twice daily, for 14 days.) inhibits tumor growth in nude mice[1].

Animal Model:Nude mice (subcutaneously injecting K562 cells)[1]
Dosage:18.75, 37.5, 75 mg/kg
Administration:Oral administration; Twice daily, for 14 days.
Result:Inhibited the growth of K562 xenografts in a dose-dependent manner and induced regression in all tumors at a daily dose of 75 mg/kg for nine days.

IC 50

PDGFRβ: 307.6 nM (IC50); c-Abl: 1.2 nM (IC50)

References

[1] Luo H, et al. HH-GV-678, a novel selective inhibitor of Bcr-Abl, outperforms imatinib and effectively overrides imatinib resistance. Leukemia. 2010 Oct;24(10):1807-9. DOI:10.1038/leu.2010.169
[2] Zhao J, et al. Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants. Cancer Sci. 2013 Nov 10. DOI:10.1111/cas.12320

Flumatinib mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Flumatinib mesylate Suppliers

China 55 United States 10 Global 65
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
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61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6468
Advantage
55
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
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View Lastest Price from Flumatinib mesylate manufacturers

Career Henan Chemical Co
Product
BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI) 895519-91-2
Price
US $1.00/KG
Min. Order
1KG
Purity
95--99%
Supply Ability
1ton
Release date
2020-01-03

895519-91-2, Flumatinib mesylateRelated Search:

Lenalidomide

  • BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI)
  • FluMatinib Mesylate
  • BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI)/FluMatinib Mesylate
  • N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)
  • methanesulfonic acid,4-[(4-methylpiperazin-1-yl)methyl]-N-[6-methyl-5-[(4-pyridin-3-ylpyrimidin-2-yl)amino]pyridin-3-yl]-3-(trifluoromethyl)benzamide
  • CS-1023
  • HHGV678 mesylate
  • Flumatinib mesylate (HHGV-678)
  • N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide methanesulfonate
  • HHGV-678,PDGFRβ,HHGV678,c-Abl,Bcr-Abl,Platelet-derived growth factor receptor,PDGFR,HHGV 678,SCFR,Flumatinib mesylate,c-Kit,Flumatinib,CD117,Inhibitor,inhibit
  • Flumatinib mesylate, 10 mM in DMSO
  • 895519-91-2
  • C29H29F3N8OCH4O3S
  • C30H33F3N8O4S