ChemicalBook > CAS DataBase List > 2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-
2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-
- Product Name
- 2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-
- CAS No.
- 1373765-19-5
- Chemical Name
- 2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-
- Synonyms
- IPSU;IPSU, 10 mM in DMSO;2-(1H-Indol-3-ylmethyl)-9-(4-methoxy-2-pyrimidinyl)-2,9-diazaspiro[5.5]undecan-1-one;inhibit,HCRT Receptor,Hypocretin Receptor,IPSU,Orexin Receptor (OX Receptor),Inhibitor;2-((1H-indol-3-yl)methyl)-9-(4-methoxypyrimidin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one;2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-
- CBNumber
- CB12667396
- Molecular Formula
- C23H27N5O2
- Formula Weight
- 405.49
- MOL File
- 1373765-19-5.mol
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2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)- Property
- Boiling point:
- 702.0±70.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:30.0(Max Conc. mg/mL);73.98(Max Conc. mM)
- form
- A crystalline solid
- pka
- 16.94±0.30(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 30007
- Product name
- IPSU
- Packaging
- 1mg
- Price
- $29
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30007
- Product name
- IPSU
- Packaging
- 25mg
- Price
- $492
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30007
- Product name
- IPSU
- Packaging
- 5mg
- Price
- $128
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30007
- Product name
- IPSU
- Packaging
- 10mg
- Price
- $225
- Updated
- 2024/03/01
TRC
- Product number
- I747515
- Product name
- IPSU
- Packaging
- 1mg
- Price
- $115
- Updated
- 2021/12/16
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2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)- Chemical Properties,Usage,Production
Uses
IPSU is a novel orexin (OX2) receptor antagonists for insomnia treatment.
in vivo
IPSU has low blood clearance, shows high maximal blood exposure and AUC after oral dosing. It exhibits an acceptable absolute oral bioavailability and a brain/blood concentration ratio that indicated favorable brain penetration. IPSU increases sleep when dosed during the mouse active phase (lights off); IPSU induces sleep primarily by increasing NREM sleep. IPSU shows a fast onset of action, with a clear increase in total sleep time during the first hour afterdosing. The effect lasts 4-5 h, after which time the total sleep time per hour is the same as on vehicle day [1].
2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)- Suppliers
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