GKA-50

Product Name: GKA-50
CAS No.: 851884-87-2
Chemical Name: GKA-50
Synonyms: GKA50;GKA-50;GKA 50;GKA-50; GKA 50;OCBMECSFDVUYQN-ROUUACIJSA-N;6-[[3-[(1S)-2-Methoxy-1-Methylethoxy]-5-[(1S)-1-Methyl-2-phenylethoxy]benzoyl]aMino]-3-pyridinecarboxylic Acid;3-Pyridinecarboxylic acid, 6-[[3-[(1S)-2-methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-
CBNumber: CB12667462
Molecular Formula: C26H28N2O6
Formula Weight: 464.51
MOL File: 851884-87-2.mol

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GKA-50 Property

Boiling point:: 607.0±55.0 °C(Predicted)
Density: 1.247±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble15mg/mL, clear
pka: 3.49±0.10(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0849
Product name: GKA50
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $203
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0849
Product name: GKA50
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $670
Updated: 2025/07/31

Tocris

Product number: 5133
Product name: GKA50
Purity: ≥98%(HPLC)
Packaging: 10
Price: $284
Updated: 2021/12/16

Usbiological

Product number: 255377
Product name: GKA 50
Packaging: 10mg
Price: $593
Updated: 2021/12/16

TRC

Product number: M264215
Product name: 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylicAcid
Packaging: 100mg
Price: $6325
Updated: 2021/12/16

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GKA-50 Chemical Properties,Usage,Production

Uses

6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid, is one of the glucokinase activator derivatives. GKAs activate GK via binding to an allosteric site of the enzyme. They increase glucose-stimulated insulin secretion and decrease blood glucose levels. Also, glucokinase activator GKA50 is shown to be able to promote proliferation by increasing the cell volume and thus, preventing apoptosis in rat pancreatic insulinoma-1 beta cell.

Biological Activity

GKA50 is a specific activator of glucokinase (EC50 = 0.03 μM). In mouse MIN6 insulin-secreting cells and r at pancreatic islet cells, GKA50 elicits a leftward shift in response to sub-maximal glucose concentrations as measured by insulin secretion and elevation of intracellular calcium levels.

in vivo

GKA50 (1-30 mg/kg; p.o.) gives significant glucose lowering in an oral glucose tolerance test^[1].

Animal Model:	High-fat-fed obese female Zucker (fa/fa) rats^[1]
Dosage:	1, 3, 10, 30?mg/kg
Administration:	Oral administration
Result:	Significant percentage glucose lowering.

storage

Store at -20°C

GKA-50 Preparation Products And Raw materials

Raw materials

Preparation Products

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GKA-50 Suppliers

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851884-87-2, GKA-50Related Search:

Polyethylene Glycol

GKA 50

GKA50

GKA-50

6-[[3-[(1S)-2-Methoxy-1-Methylethoxy]-5-[(1S)-1-Methyl-2-phenylethoxy]benzoyl]aMino]-3-pyridinecarboxylic Acid

OCBMECSFDVUYQN-ROUUACIJSA-N

GKA-50; GKA 50

3-Pyridinecarboxylic acid, 6-[[3-[(1S)-2-methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-

851884-87-2