BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]-

Product Name: BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]-
CAS No.: 1208123-85-6
Chemical Name: BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]-
Synonyms: CaMKII-IN-1;CaMKII inhibitor 1;CaMKII-IN-1, 10 mM in DMSO;N-[6-benzyl-2-(2-phenylethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]-3-chloro-2-methylbenzenesulfonamide;N-{6-Benzyl-2-[(2-phenylethyl)amino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl}-3-chloro-2-methylbenzenesulfonamide;Calmodulin-dependent protein kinases,Calmodulin-dependent kinases,inhibit,CaMKII IN 1,CaMKIIIN1,CaMK,Autophagy,Inhibitor;3-chloro-2-methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)amino]-6-(phenylmethyl)pyrido[4,3-d]pyrimidin-4-yl]benzenesulfonamide;BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]-
CBNumber: CB12668212
Molecular Formula: C29H30ClN5O2S
Formula Weight: 548.1
MOL File: 1208123-85-6.mol

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BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]- Property

Melting point:: 208-210 °C (decomp)
Boiling point:: 728.2±70.0 °C(Predicted)
Density: 1.349±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 54 mg/mL (98.52 mM)
form: Solid
pka: 3.94±0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3440
Product name: CaMKII-IN-1
Purity: 99.74%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-3440
Product name: CaMKII-IN-1
Purity: 99.74%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611801
Product name: CaMKII-IN-1
Packaging: 10mg
Price: $615.4
Updated: 2021/12/16

ChemScene

Product number: CS-3440
Product name: CaMKII-IN-1
Purity: 99.74%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611801
Product name: CaMKII-IN-1
Packaging: 50mg
Price: $1802
Updated: 2021/12/16

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BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]- Chemical Properties,Usage,Production

Uses

CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC. IC50 value: 63 nM Target: CaMKII

References

[1] Asano S, et al. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6696-8. DOI:10.1016/j.bmcl.2010.09.005

BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]- Suppliers

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1208123-85-6, BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]-Related Search:

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BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]-

CaMKII-IN-1

3-chloro-2-methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)amino]-6-(phenylmethyl)pyrido[4,3-d]pyrimidin-4-yl]benzenesulfonamide

N-[6-benzyl-2-(2-phenylethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]-3-chloro-2-methylbenzenesulfonamide

N-{6-Benzyl-2-[(2-phenylethyl)amino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl}-3-chloro-2-methylbenzenesulfonamide

CaMKII inhibitor 1

Calmodulin-dependent protein kinases,Calmodulin-dependent kinases,inhibit,CaMKII IN 1,CaMKIIIN1,CaMK,Autophagy,Inhibitor

CaMKII-IN-1, 10 mM in DMSO

1208123-85-6

C29H30ClN5O2S