ChemicalBook > CAS DataBase List > Senexin A

Senexin A

Product Name: Senexin A
CAS No.: 1366002-50-7
Chemical Name: Senexin A
Synonyms: Senexin A;Senexin A, 10 mM in DMSO;4-(Phenethylamino)quinazoline-6-carbonitrile;4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitrile;Senexin A (This product is unavailable in the U.S.);6-Quinazolinecarbonitrile, 4-[(2-phenylethyl)amino]-;Cyclin dependent kinase,Senexin A,Inhibitor,CDK,inhibit
CBNumber: CB12668227
Molecular Formula: C17H14N4
Formula Weight: 274.32
MOL File: 1366002-50-7.mol

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Senexin A Property

Boiling point:: 520.0±45.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 100 mg/mL (364.54 mM)
pka: 6.47±0.50(Predicted)
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 4875
Product name: SenexinA
Purity: ≥98%(HPLC)
Packaging: 10
Price: $238
Updated: 2021/12/16

ChemScene

Product number: CS-6893
Product name: SenexinA
Purity: 99.94%
Packaging: 2mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-6893
Product name: SenexinA
Purity: 99.94%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-6893
Product name: SenexinA
Purity: 99.94%
Packaging: 50mg
Price: $720
Updated: 2021/12/16

Matrix Scientific

Product number: 100590
Product name: 4-(Phenethylamino)quinazoline-6-carbonitrile
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

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Senexin A Chemical Properties,Usage,Production

Uses

Senexin A is a useful intermediate.

in vivo

Five daily treatment of Senexin A fully reverses tumor-promoting effect of chemotherapy. Senexin A shows no detectable toxicity and no significant effects on body weight, organ weights, or blood cell counts in C57BL/6 mice during the treatment. This effect of doxorubicin treatment is completely abolished, however, when doxorubicin injection is followed by administration of Senexin A. Senexin A treatment strongly improves the response of A549/MEF tumors to doxorubicin^[1].

IC 50

CDK19: 0.31 μM (Kd); CDK8: 0.83 μM (Kd); CDK8: 280 nM (IC₅₀)

Senexin A Preparation Products And Raw materials

Raw materials

Preparation Products

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Senexin A Suppliers

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1366002-50-7, Senexin ARelated Search:

Senexin A

4-(Phenethylamino)quinazoline-6-carbonitrile

6-Quinazolinecarbonitrile, 4-[(2-phenylethyl)amino]-

Senexin A (This product is unavailable in the U.S.)

4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitrile

Cyclin dependent kinase,Senexin A,Inhibitor,CDK,inhibit

Senexin A, 10 mM in DMSO

1366002-50-7