ChemicalBook > CAS DataBase List > PCI 29732

PCI 29732

Product Name: PCI 29732
CAS No.: 330786-25-9
Chemical Name: PCI 29732
Synonyms: CS-2698;PCI 29732;PCI 29732, 10 mM in DMSO;PCI 29732;PCI29732;PCI-29732;PCI 29732 (This product is only available in Japan.);1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;4-Amino-1-cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-cyclopentyl-3-(4-phenoxyphenyl)-;cytotoxicity,Bruton tyrosine kinase,Inhibitor,Btk,ABCG2,reversible,PCI 29732,BCR,inhibit,B-cell,BCRP,oral,Breast cancer resistance protein
CBNumber: CB12668434
Molecular Formula: C22H21N5O
Formula Weight: 371.43
MOL File: 330786-25-9.mol

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PCI 29732 Property

Boiling point:: 599.6±50.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
pka: 4.24±0.30(Predicted)
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29036
Product name: PCI-29732
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29036
Product name: PCI-29732
Packaging: 25mg
Price: $533
Updated: 2024/03/01

Cayman Chemical

Product number: 29036
Product name: PCI-29732
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 29036
Product name: PCI-29732
Packaging: 10mg
Price: $230
Updated: 2024/03/01

Tocris

Product number: 5012
Product name: PCI29732
Purity: ≥99%(HPLC)
Packaging: 10
Price: $207
Updated: 2021/12/16

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PCI 29732 Chemical Properties,Usage,Production

Uses

PCI 29732 (cas# 330786-25-9) is a useful research chemical. It is a COVID19-related research product.

Definition

ChEBI: 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is an aromatic ether.

in vivo

PCI 29732 inhibits the function of ABCG2 by competitively binding to the ATP-binding site of ABCG2 and enhances the anti-tumor efficacy of substrate chemotherapeutic agents^[2].
PCI 29732 (20 mg/kg; p.o.; every 3 d × 5 times) enhances the anticancer efficacy of Topotecan in the H460/MX20 cell xenograft nude mice model^[2].

Animal Model:	5-6 weeks old athymic nude mice (bearing H460/MX20 cells)^[2]
Dosage:	20 mg/kg (combination with Topotecan; every 3 d × 5 times, i.p., 3 mg/kg; topotecan was given 1 h after PCI29732 administration)
Administration:	P.o.; every 3 d × 5 times
Result:	Significant reductions in tumor weight and volume were observed in the group treated with PCI29732 in combination with Topotecan.

storage

Store at +4°C

PCI 29732 Preparation Products And Raw materials

Raw materials

Preparation Products

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PCI 29732 Suppliers

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330786-25-9, PCI 29732Related Search:

PCI 29732

4-Amino-1-cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine

1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

PCI 29732 (This product is only available in Japan.)

CS-2698

PCI 29732;PCI29732;PCI-29732

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-cyclopentyl-3-(4-phenoxyphenyl)-

cytotoxicity,Bruton tyrosine kinase,Inhibitor,Btk,ABCG2,reversible,PCI 29732,BCR,inhibit,B-cell,BCRP,oral,Breast cancer resistance protein

PCI 29732, 10 mM in DMSO

330786-25-9